(Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture

Meeuwen, J.A. van; Korthagen, N.M.; Jong, P.C. de; Piersma, Aldert H.; Berg, Martin van den

doi:10.1016/j.taap.2007.03.016

Cited by 76 publications

(49 citation statements)

References 51 publications

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“…As noted above, yarrow contains flavonoids that have weak estrogenic activity in vitro; van Meeuwen et al (2007) suggest that apigenin and other flavonoid "food supplements" may potentiate the growth of breast cancer. These purified compounds are not sold as dietary supplements, and many commonly consumed plants contain them.…”

Section: Safety and Toxicologymentioning

confidence: 97%

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

2011

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Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research. Yarrow (Achillea millefolium L.) is one of the most widely used medicinal plants in the world, primarily for wounds, digestive problems, respiratory infections, and skin conditions, and secondarily, among other uses, for liver disease and as a mild sedative. Preclinical studies indicate that it may have anti-inflammatory, anti-ulcer, hepatoprotective, anxiolytic, and perhaps antipathogenic activities. Animal studies have also shown that yarrow is generally safe and well tolerated. The claim that yarrow has been shown to be specifically contraindicated during pregnancy is based on a single low-quality rat study the results of which were incorrectly interpreted. The combination of human use data from multiple cultures, independently reporting similar activities for yarrow, and the discovery of potentially relevant bioactivities by in vitro and animal studies represent meaningful evidence of the plant's efficacy. We therefore argue that human clinical trials should be funded and conducted.

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Section: Safety and Toxicologymentioning

confidence: 97%

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

2011

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“…Among them, naringenin and its glycoside naringin are abundant in grapefruit and citrus fruits and juices (14,15). Previous studies have shown that naringenin inhibits CYP3A4 activity and exhibits aorta dilatory, antioxidant, antiestrogenic, antiproliferative and antimetastatic effects (16)(17)(18)(19)(20). Recently, naringenin, but not naringin, has been reported to induce apoptosis in various human cancer cells and treatment with a similar dose showed no toxic effect on normal cells (21)(22)(23)(24)(25).…”

Section: Introductionmentioning

confidence: 99%

Naringenin attenuates the release of pro-inflammatory mediators from lipopolysaccharide-stimulated BV2 microglia by inactivating nuclear factor-κB and inhibiting mitogen-activated protein kinases

Choi¹

2012

Int J Mol Med

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Abstract. Naringenin, one of the most abundant flavonoids in citrus fruits and grapefruits, has been reported to exhibit anti-inflammatory and antitumor activities. However, the cellular and molecular mechanisms underlying the naringenin anti-inflammatory activity are poorly understood. In this study, we conducted an investigation of the inhibitory effects of naringenin on the production of lipopolysaccharide (LPS)-induced pro-inflammatory mediators in BV2 microglial cells. We found that pre-treatment with naringenin prior to treatment with LPS significantly inhibited excessive production of nitric oxide (NO) and prostaglandin E 2 (PGE 2 ) in a dose-dependent manner. The inhibition was associated with downregulation of inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) expression. Naringenin also attenuated the production of pro-inflammatory cytokines and chemokines, including interleukin-1β (IL-1β), tumor necrosis factor-α (TNF-α) and monocyte chemoattractant protein-1 (MCP-1) by suppressing expression of mRNAs for these proteins. In addition, the molecular mechanism underlying naringenin-mediated attenuation in BV2 cells has a close relationship to suppressing translocation of the nuclear factor-κB (NF-κB) p65 subunit into the nucleus and the phosphorylation of Akt and mitogen-activated protein kinases (MAPKs). These findings suggest that naringenin may provide neuroprotection through suppression of pro-inflammatory pathways in activated BV2 microglial cells.

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“…For example, quercetin inhibits the activities of proteins, such as p-glycoprotein, protein kinase C, and topoisomerase II, by binding to ATP binding sites [8]. Quercetin inhibits the expression of heat shock proteins and acts as a phytoestrogen [9,10]. However, most of these effects have only been demonstrated in vitro at relatively high concentrations of quercetin.…”

Section: Introductionmentioning

confidence: 99%

Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin‐induced disturbance of hepatic gene expression in mice

Kobori¹,

Masumoto

Akimoto

et al. 2009

Molecular Nutrition Food Res

186

125

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Quercetin is a food component that may ameliorate the diabetic symptoms. We examined hepatic gene expression of BALB/c mice with streptozotocin (STZ)-induced diabetes to elucidate the mechanism of the protective effect of dietary quercetin on diabetes-associated liver injury. We fed normal and STZ-induced diabetic mice with diets containing quercetin for 2 wk and compared the patterns of hepatic gene expression in these groups of mice using a DNA microarray. Diets containing 0.1 or 0.5% quercetin lowered the STZ-induced increase in blood glucose levels and improved plasma insulin levels. A cluster analysis of the hepatic gene expressions showed that 0.5% quercetin diet suppressed STZ-induced alteration of gene expression. Gene set enrichment analysis (GSEA) and quantitative RT-PCR analysis showed that the quercetin diets had greatest suppressive effect on the STZ-induced elevation of expression of cyclin-dependent kinase inhibitor p21(WAF1/Cip1) (Cdkn1a). Quercetin also suppressed STZ-induced expression of Cdkn1a in the pancreas. Dietary quercetin might improve liver and pancreas functions by enabling the recovery of cell proliferation through the inhibition of Cdkn1a expression. Unexpectedly, in healthy control mice the 0.5 and 1% quercetin diets reduced the expression of ubiquitin C (Ubc), which has heat-shock element (HSE) in the promoter region, in the liver.

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(Anti)estrogenic effects of phytochemicals on human primary mammary fibroblasts, MCF-7 cells and their co-culture

Cited by 76 publications

References 51 publications

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

Yarrow (Achillea millefolium L.): A Neglected Panacea? A Review of Ethnobotany, Bioactivity, and Biomedical Research1

Naringenin attenuates the release of pro-inflammatory mediators from lipopolysaccharide-stimulated BV2 microglia by inactivating nuclear factor-κB and inhibiting mitogen-activated protein kinases

Dietary quercetin alleviates diabetic symptoms and reduces streptozotocin‐induced disturbance of hepatic gene expression in mice

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