Anti-fatigue property of the oyster polypeptide fraction and its effect on gut microbiota in mice

Xiao, Meifang; Lin, Luan; Chen, Hongpei; Ge, Xiaodong; Huang, Ying; Zheng, Zong‐Ping; Li, Shiming; Pan, Yong; Liu, Bin; Zeng, Feng

doi:10.1039/d0fo01713b

Cited by 45 publications

(42 citation statements)

References 43 publications

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“…Gut microbiota in faecal samples was analysed in 16 studies, 32,36–38,41–45,49–51,54,57–59 and 5 studies extracted microbiome from the caecum, 32,52,53,55,56 colon, 56 or small intestine 56 . High‐throughput 16s rRNA sequencing were performed on diverse platforms in 16 studies, 32,36–38,41,43–45,49,51–53,55,57–59 with amplified hypervariable region 3–4 (V3–V4), 32,38,49,51–53,55,59 V3, 36 V4, 37,41,45,58 V1 and V3, 57 or V4–V6 43 . Two studies utilized metagenomic sequencing, 42,44 and two used quantitative polymerase chain reaction (PCR) to quantify the bacteria 58,59 .…”

Section: Resultsmentioning

confidence: 99%

“…Two studies utilized metagenomic sequencing, 42,44 and two used quantitative polymerase chain reaction (PCR) to quantify the bacteria 58,59 . The abundance or relative abundance of microbiota was studied on phylum, class, order, family, genus, or species levels in 18 studies 32,36–38,41–45,49,51–53,55–59 . Five studies assessed the concentrations of SCFAs in faeces by 1 H nuclear magnetic resonance spectroscopy and gas or liquid chromatography 42,50,54,56,58 .…”

Section: Resultsmentioning

confidence: 99%

“…Five studies assessed the concentrations of SCFAs in faeces by 1 H nuclear magnetic resonance spectroscopy and gas or liquid chromatography 42,50,54,56,58 . Alpha diversity was presented in 9 studies, 32,36,38,41,43,45,51,58,59 and beta diversity was evaluated in 11 studies 32,36,38,41,43–45,51,52,55,59 …”

Section: Resultsmentioning

confidence: 99%

“…Muscle strength were assessed in 13 studies, using forelimb grip strength test, 32,39,41,44,47–50,52–54 four‐limb hanging test, 47 or ex vivo muscle contractile function 59 . Serum fatigue‐related markers were reported in seven studies 48–50,52–55 …”

Section: Resultsmentioning

confidence: 99%

“…Curcumin as prebiotics ameliorated gut microbiome composition, muscle mass, and functions 52 . High microbiome‐accessible carbohydrate (HMC) diet, oyster polypeptide (OP), and kefir composed of lactic acid bacteria could also improve muscle mass and/or performance by shifting intestinal microbes 52,53,55,58 . Beef extract (BE) had microbiota‐independent effects on muscle function promotion 54 .…”

Section: Resultsmentioning

confidence: 99%

See 4 more Smart Citations

Understanding the gut microbiota and sarcopenia: a systematic review

Liu

Cheung

et al. 2021

J cachexia sarcopenia muscle

180

100

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Background Gut microbiota dysbiosis and sarcopenia commonly occur in the elderly. Although the concept of the gut–muscle axis has been raised, the casual relationship is still unclear. This systematic review analyses the current evidence of gut microbiota effects on muscle/sarcopenia. Methods A systematic review was performed in PubMed, Embase, Web of Science, and The Cochrane Library databases using the keywords (microbiota* OR microbiome*) AND (sarcopen* OR muscle). Studies reporting the alterations of gut microbiota and muscle/physical performance were analysed. Results A total of 26 pre‐clinical and 10 clinical studies were included. For animal studies, three revealed age‐related changes and relationships between gut microbiota and muscle. Three studies focused on muscle characteristics of germ‐free mice. Seventy‐five per cent of eight faecal microbiota transplantation studies showed that the recipient mice successfully replicated the muscle phenotype of donors. There were positive effects on muscle from seven probiotics, two prebiotics, and short‐chain fatty acids (SCFAs). Ten studies investigated on other dietary supplements, antibiotics, exercise, and food withdrawal that affected both muscle and gut microbiota. Twelve studies explored the potential mechanisms of the gut–muscle axis. For clinical studies, 6 studies recruited 676 elderly people (72.8 ± 5.6 years, 57.8% female), while 4 studies focused on 244 young adults (29.7 ± 7.8 years, 55.4% female). The associations of gut microbiota and muscle had been shown in four observational studies. Probiotics, prebiotics, synbiotics, fermented milk, caloric restriction, and exercise in six studies displayed inconsistent effects on muscle mass, function, and gut microbiota. Conclusions Altering the gut microbiota through bacteria depletion, faecal transplantation, and various supplements was shown to directly affect muscle phenotypes. Probiotics, prebiotics, SCFAs, and bacterial products are potential novel therapies to enhance muscle mass and physical performance. Lactobacillus and Bifidobacterium strains restored age‐related muscle loss. Potential mechanisms of microbiome modulating muscle mainly include protein, energy, lipid, and glucose metabolism, inflammation level, neuromuscular junction, and mitochondrial function. The role of the gut microbiota in the development of muscle loss during aging is a crucial area that requires further studies for translation to patients.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

See 3 more Smart Citations

Understanding the gut microbiota and sarcopenia: a systematic review

Liu

Cheung

et al. 2021

J cachexia sarcopenia muscle

180

100

View full text Add to dashboard Cite

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The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice

Kan

Liu

Huang

et al. 2022

Food Science & Nutrition

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Polysaccharide (PF40) has been recognized as a main bioactive substances inPseudostellaria heterophylla (Miq.). The current study explored the potential protective effects of PF40 on immune system in mice with cyclophosphamide-induced immunosuppression. The mice were intragastric administered PF40 at the dosage of 100, 200 or 400 mg/kg once daily for 30 days, On the 24th and 25th day, the additional intraperitoneal injection of PF40 (50 mg/kg) were administered. The results showed that PF40 enhanced the cell-mediated immunity via improvements in macrophage phagocytosis, splenocyte proliferation, NK cell activity and delayed type hypersensitivity. Equally, it improves humoral immunity through promoting the formation of serum hemolysin.Moreover, PF40 maintain the immune balance of splenic lymphocytes and altered the intestinal physiological status in Cyp-induced mice. PF40 regulates the intestinal microbiota by restoring the relative abundance of Odoribacter and Mucispirillum and reducing the relative abundance of Sporosarcina, Yaniella, and Jeotgalicoccus in Cypintervened mice. The findings suggested that PF40 might be a promising natural functional foods for reducing chemotherapy-induced immunosuppression.

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The anti‐fatigue activity of corn peptides and their effect on gut bacteria

Feng

Wei

et al. 2021

J Sci Food Agric

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BACKGROUND Corn peptides (CPs) are rich in branched‐chain amino acids such as leucine and have a variety of biological activities such as antioxidant and improved lipid distribution. In this article, we prepared CPs by enzymatic digestion of corn proteins and evaluated their anti‐fatigue activity. RESULTS We evaluated the anti‐fatigue effect of CPs through an exhaustive swimming experiment. The results showed that CPs were able to significantly reduce the rate of body weight gain and prolong the duration of exhaustive swimming. Besides, CPs reduced blood urea nitrogen (BUN) levels after exercise, while they significantly increased muscle glycogen and liver glycogen stores. They reduced muscle cell damage from exercise. In addition, CPs were effective in increasing AMPK, PGC‐1α and PI3K protein expression levels and promoting Akt phosphorylation. Correlation analysis showed that CPs increased the abundance of probiotics such as Lactobacillus and Akkermansia in the gut microflora. CONCLUSION CPs, which enhanced exercise performance in mice and could modulate gut microbial composition, had significant anti‐fatigue activity. © 2021 Society of Chemical Industry.

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Anti-fatigue property of the oyster polypeptide fraction and its effect on gut microbiota in mice

Abstract: We aimed to evaluate the anti-fatigue effects of oyster polypeptide (OP) fraction and its regulatory effect on intestinal microbiota in mice. Exhaustive swimming experiment showed that the swimming time of...

Cited by 45 publications

References 43 publications

Understanding the gut microbiota and sarcopenia: a systematic review

Understanding the gut microbiota and sarcopenia: a systematic review

The regulatory effects of Pseudostellaria heterophylla polysaccharide on immune function and gut flora in immunosuppressed mice

The anti‐fatigue activity of corn peptides and their effect on gut bacteria

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