Anti-fertility effect of various plants at Dayak Tribe to Swiss Webster Mice

Abstract

Blumea balsamifera, Croton tiglium, Metroxylon sagu, and Fagraea racemosa are used as traditional antifertility of Dayak people in Central Kalimantan. These study aims at finding out the potential plants as antifertility with the use on Swiss Webster (SW) mice. Extracts of B. balsamifera, C. tiglium, M. sagu, and F. racemosa were administered by gavage at the dose level of 0.26 mg/kg body weight (b.w) to female of SW mice for 8 days to examine their estrous cycle. To determine the anti-fertility, the procedure was to administer 0.26 mg/kg b.w of plant extract by gavageto female SW mice and mated it with normal male of SW mice. Estrous cycle were analyzed every day for 9 days and the reproduction display was examined 15 days after fertilization. The results show that there is an inhibitation in estrous cycle, particularly on estrus and metestrus phases for all of the traditional plant extracts. The reproduction display shows a decrease in the number of live fetuses, number of corpus luteum and body weight of the dam mice treated. The decrease in the corpus luteum further and fetuses attributes antifertilty effect of extract to inhibit foliculogenesis. Out of four extracts tested, the extract of B. balsamifera seems to be more potential for antifertility activities when compared with other traditional plant extracts.

Phytochemical composition and health properties of Sembung plant (Blumea balsamifera): A review

“…A decrease in the corpus luteum and fetus was attributed to the anti-infertility effect of the extract against the inhibition of folliculogenesis. Researchers also reported that B. balsamifera extract had promising anti-infertility activity compared to other plant extracts used in this study [66].…”

“…Various experimental studies both in vitro and in vivo have reported the pharmacological activities of B. balsamifera, such as antioxidant, cytotoxic, antimicrobial, antifungal, anti-inflammatory, and hypolipidemic. Table-2 [13,22,56,[62][63][64][65][66][67][68][69][70][71][72][73][74][75][76][77][78][79][80] summarizes some studies on the pharmacological activity of B. balsamifera.…”

Effect of water decoction of Langsat bark (Lansium domesticum Corr.) on estrous cycle and uterus weight in mice (Mus musculus L.)

“…Some of the compounds found in plants are useful as anti-fertility include steroids, flavonoids and alkaloids. 17 There are no reports that the Langsat's bark containing these components, so use as a drug anti-fertility not appropriate.…”