Anti fibrogenesis effect of green materials Moringa oleifera leaf powder (MOLP) on the progression of hepatocellular carcinoma

Susanto, Hendra; Yunisa, Dinda Tri; Taufiq, Ahmad; Putra, Wira Eka; Jannah, Nur Aini Sholihatun; Putri, Shabrina Andira; Dewi, Ikke Astrid; Febriyanti, Qori Dini Ayu; Mufidah, Ikfi Nihayatul

doi:10.1063/5.0052554

Cited by 6 publications

(4 citation statements)

References 35 publications

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“…The quercetin content in M. oleifera seed oil is also involved in the inflammation process, by hampering the neutral factor kappa-beta (NF-kβ) activity (Das et al, 2012). In addition to obstructing the inflammation process, the drumstick tree also has the ability to reduce the TGF-β level, the primary fibrosis regulator (Fabregat & Caballero-Díaz, 2018;Susanto et al, 2021). The phenol in M. oleifera seed oil decreases liver fibrosis due to CCl4 induction by suppressing hepatic stellate cell activation through obstructing the TGF-β/Smad3 signaling pathway (Wu et al, 2018).…”

Section: Resultsmentioning

confidence: 99%

Anti-liver fibrosis of green materials Moringa oleifera seed oils from Madura Island against hepatocellular carcinoma development

Susanto

Taufiq²,

Malek³

et al. 2022

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Section: Resultsmentioning

confidence: 99%

Anti-liver fibrosis of green materials Moringa oleifera seed oils from Madura Island against hepatocellular carcinoma development

Susanto

Taufiq²,

Malek³

et al. 2022

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“…It indicated that 6 wk administration of the M. oleifera leaf extract has a curative effect against rat liver fibrosis. Susanto et al 21 reported that administration of M. oleifera leaf extract for 6 wk significantly decrease in TNF-β expression and prevent hepatocellular carcinoma progression.…”

Section: Discussionmentioning

confidence: 99%

The curative effect of ethanolic extract of Moringa oleifera leaf in an animal model of liver fibrosis

Supriono,

Putri,

Priyanto

et al. 2024

InaJBCS

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Studies about the prevention effect of Moringa oleifera on liver fibrosis has been reported. However, its curative effect has not been reported, yet. This study was conducted to evaluate the curative effect of M. oleifera leaf extract on liver fibrosis. It was a laboratory experimental study with a post-test-only control group design. Rats were divided into 5 groups i.e. normal control which received intraperitoneally injections of 1 mL/kg BW of 0.9% NaCl solution twice a wk for 11 wk. Liver fibrosis control which received intraperitoneally injections of 1 mL/kg BW of 10% CCl4 solution twice a wk for 11 wk. Three M. oleifera treatment group which received intraperitoneally injections of 1 mL/kg BW of 10% CCl4 solution twice a wk for 11 wk continued by M. oleifera leaf ethanolic extract at dose of 600 mg/kg BW daily for 3 (MO3), 6 (MO6), and 10 (MO10) wk, respectively. The liver fibrosis level was assessed based on the METAVIR score. Histopathological analysis of liver tissues demonstrated that the 11-week CCl4 induction successfully resulted in liver fibrosis in rats (F3 and F4). The administration of M. oleifera leaf ethanolic extract decreased METAVIR scores ranged from F3 to F1. The optimal reduction of the METAVIR scores (F1) was observed in MO3 group after 6 wk administration (p<0.05). It was indicated that M. oleifera leaf ethanolic extract ameliorated liver fibrosis. In conclusion, M. oleifera leaf ethanolic extract has a curative effect against liver fibrosis.

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“…In the current experiment, the administration of MOE reduced the expression of TGF-β1; this reduction was attributed to MOE's role in attenuating the KBrO 3 -induced fibrosis process. In addition, Susanto et al [32] showed the significant activity of MO in decreasing TGF-β1 expression in the mice model that developed hepatocellular carcinoma.…”

Section: Discussionmentioning

confidence: 99%

Protective Effect of Aqueous Extract of Moringa Oleifera Leaves Against Potassium Bromate-Induced Renal Toxicity in Rats

Kamel

Fouad²,

Mohamed³

2022

Egyptian Journal of Zoology

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KBrO 3 is a vital component used in food, beer, pharmaceutical, and cosmetic productions; it produces moderate-to-dangerous toxic insults to a variety of organs. This study aimed to investigate if Moringa oleifera leaves aqueous extract (MOE) can protect rats from KBrO 3 -induced renal toxicity. Four experimental groups of male albino rats (Sprague Dawley) were used here (n=8): control, MOE (400 mg/kg body weight), KBrO 3 (100 mg/kg body weight), and KBrO 3 in combination with MOE groups. Daily for six weeks, each group received orally its unique treatment. After the experimental period kidneys and serum were collected for biochemical, molecular, and histological investigations. The KBrO 3 treatment was associated with a significant rise in serum levels of urea, creatinine, sodium, and potassium. KBrO 3 also caused a significant increase in the renal tissue levels of malondialdehyde and nitric oxide, while reducing the activities of antioxidant enzymes in the renal tissues. Moreover, KBrO 3 led to kidney inflammation and fibrosis by increasing the tumor necrosis factor-α, interleukin-6, and tumor growth factor-β1, which was followed by upregulation in the renal expression of miRNA 21 (miR-21), miR-29, and miR-192. In comparison to the control group, histopathological evaluation of the KBrO 3 group revealed degenerative alterations and damage in the kidney tissues. Conversely, co-treatment with MOE revealed a noticeable alleviation of the harmful effects of KBrO 3 in almost all examined parameters. In conclusion, MOE could be utilized as an alternative therapy to alleviate the detrimental effects of KBrO 3 on kidneys due to its antioxidant, antiinflammatory, and anti-fibrotic activities.

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Anti fibrogenesis effect of green materials Moringa oleifera leaf powder (MOLP) on the progression of hepatocellular carcinoma

Cited by 6 publications

References 35 publications

Anti-liver fibrosis of green materials Moringa oleifera seed oils from Madura Island against hepatocellular carcinoma development

Anti-liver fibrosis of green materials Moringa oleifera seed oils from Madura Island against hepatocellular carcinoma development

The curative effect of ethanolic extract of Moringa oleifera leaf in an animal model of liver fibrosis

Protective Effect of Aqueous Extract of Moringa Oleifera Leaves Against Potassium Bromate-Induced Renal Toxicity in Rats

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