Anti-fibrotic effect of trans-resveratrol on pancreatic stellate cells

Tsang, Siu Wai; Zhang, Hongjie; Lin, Zesi; Mu, Haibo; Bian, Zhaoxiang

doi:10.1016/j.biopha.2015.02.013

Cited by 26 publications

(20 citation statements)

References 26 publications

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“…Indeed, a large body of recent reports has verified the health-promoting bioactivity of RSV333435363738. As one of its many effects, RSV has been reported to have a therapeutic effect on nasal polyps639.…”

Section: Discussionmentioning

confidence: 99%

Sinonasal Delivery of Resveratrol via Mucoadhesive Nanostructured Microparticles in a Nasal Polyp Mouse Model

Lee

Park

Huh

et al. 2017

Sci Rep

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Resveratrol (RSV) has been shown to effectively suppress chronic rhinosinusitis with nasal polyps in a mouse model; however, when locally administered to the sinonasal cavity, bolus RSV is limited by low drug bioavailability owing to its low aqueous solubility and relatively rapid clearance from the administration site. To address this limitation, we propose mucoadhesive nanostructured microparticles (PLGA/PEG NM) as a potential carrier for the sinonasal delivery of RSV. In this study, PLGA/PEG NM released RSV in a sustained manner. Owing to the enlarged specific surface area of the nanostructures, PLGA/PEG NM had synergistically enhanced mucoadhesiveness and thus showed improved in vivo retention properties in the sinonasal cavity. Therefore, when tested in a mouse nasal polyp model, PLGA/PEG NM mitigated polyp formation and restored epithelial integrity better than the control treatments. The therapeutic effect was similar at half the dose of PLGA/PEG NM, suggesting improved local bioavailability of RSV in the sinonasal cavity.

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Section: Discussionmentioning

confidence: 99%

Sinonasal Delivery of Resveratrol via Mucoadhesive Nanostructured Microparticles in a Nasal Polyp Mouse Model

Lee

Park

Huh

et al. 2017

Sci Rep

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“…Desmoplasia, a dominant characteristic of the pancreatic ductal adenocarcinoma (PDAC) tumor microenvironment, is induced by activation of pancreatic stellate cells (PSCs), which synthesize and secrete large amounts of ECM, as well as other factors, such as cytokines and growth factors, which can promote fibrosis and accelerate tumor growth . Tsang et al . and Lin et al .…”

Section: The Role Of Resveratrol In the Tumor Microenvironmentmentioning

confidence: 99%

Resveratrol and cancer treatment: updates

Jiang

Chen

Liu

et al. 2017

Annals of the New York Academy of Sciences

114

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Cancer, a growing health problem worldwide, affects millions of people every year. The overall survival rates of most cancers have been prolonged owing to the efforts of clinicians and scientists. However, some tumors develop resistance to chemoradiotherapeutic agents, and the cancer research community continues to search for effective sensitizers. Resveratrol, a natural polyphenolic phytoalexin, has shown promising effects in inhibiting proliferation and cancer progression in several tumor models. However, its molecular mechanisms and applications in chemotherapy and radiotherapy have yet to be fully determined. In this concise review, we highlight the role and related molecular mechanisms of resveratrol in cancer treatment. In particular, we focus on the role of resveratrol in the tumor microenvironment and the sensitization of cancer cells for chemotherapy and radiotherapy. Resveratrol shows promising efficacies in cancer treatment and may be applied in clinical therapy, but it requires further clinical study.

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“…Total RNA was extracted from LTC-14 and PANC-1 cells using TRIzol reagent (Invitrogen) according to the manufacturer's instruction and procedures described previously [25]. Two μg of RNA of each sample was transcribed into cDNA using PrimeScript RT master mix (Takara) in a total volume of 20 μl.…”

Section: Real-time Quantitative Polymerase Chain Reaction (Qpcr)mentioning

confidence: 99%

Eruberin A, a Natural Flavanol Glycoside, Exerts Anti-Fibrotic Action on Pancreatic Stellate Cells

Tsang

Zhang

Chen

et al. 2015

Cell Physiol Biochem

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Background: Eruberin A (2, 3-dehydroflavonoid), a flavanol glycoside isolated from Pronephrium penangianum, has been used as a blood-nourishing folk medicine for centuries; however, it indeed possesses a variety of other health-promoting benefits including anti-fibrotic bioactivity. Activation of pancreatic stellate cells (PSCs) is the key initiating step in pancreatic fibrosis, which is a characteristic feature associated with chronic pancreatitis and pancreatic adenocarcinoma. Methods: The anti-fibrotic effect of eruberin A and the underlying mechanisms of its anti-fibrotic action in LTC-14 cells, which retained essential characteristics and morphological features of primary PSCs, were examined by means of real-time polymerase chain reactions, Western blotting and immunostaining. Results: The application of eruberin A (20 µg/ml) effectively inhibited the expression levels of fibrotic mediators namely alpha-smooth muscle actin, fibronectin and type I-collagen, so as the sonic hedgehog signaling pathway components post transforming growth factor-beta (5 ng/ml) stimulation. Eruberin A treatment also led to a notable decrease in the activation of nuclear factor-kappaB (NF-κB) and the phosphorylation of phosphoinositide 3-kinase (PI3K)/serine-threonine kinase (AKT). Conclusion: Our results demonstrated that eruberin A significantly suppressed the expression levels of fibrotic mediators in PSCs, and we suggest that its anti-fibrotic mechanism was associated with an attenuation of the PI3K/AKT/NF-κB signaling pathway.

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Anti-fibrotic effect of trans-resveratrol on pancreatic stellate cells

Cited by 26 publications

References 26 publications

Sinonasal Delivery of Resveratrol via Mucoadhesive Nanostructured Microparticles in a Nasal Polyp Mouse Model

Sinonasal Delivery of Resveratrol via Mucoadhesive Nanostructured Microparticles in a Nasal Polyp Mouse Model

Resveratrol and cancer treatment: updates

Eruberin A, a Natural Flavanol Glycoside, Exerts Anti-Fibrotic Action on Pancreatic Stellate Cells

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