Anti-Food Allergic Activity of Sulfated Polysaccharide from Gracilaria lemaneiformis is Dependent on Immunosuppression and Inhibition of p38 MAPK

Abstract

(2016) AntiFood allergic activity of sulfated polysaccharide from Gracilaria lemaneiformisis dependent in immunosuppression and inhibition of p38 MAPK. Journal of Agricultural and Food Chemistry, 64 (22). pp. 4536-4544. ISSN 0021-8561Access from the University of Nottingham repository: http://eprints.nottingham.ac.uk/43933/1/Revised%20Manuscript1.pdf Copyright and reuse:The Nottingham ePrints service makes this work by researchers of the University of Nottingham available open access under the following conditions. This article is made available under the University of Nottingham End User licence and may be reused according to the conditions of the licence. For more details see: http://eprints.nottingham.ac.uk/end_user_agreement.pdf A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. Gracilaria lemaneiformis (GLSP), investigate the effects of GLSP on the anti-allergic 29 activity in both animal and cell models, and explore its anti-allergic mechanisms.

Characterization of Exopolysaccharides Produced by Thermophilic Lactic Acid Bacteria Isolated from Tropical Fruits of Thailand

“…32) Furthermore, natural polysaccha- rides from marine algae (Gracilaria lemaneiformis) 33) and terrestrial plants (Ganoderma tsugae and Angelica sinensis) 34,35) have been shown to exhibit inhibitory effects against immunoglobulin E (IgE)-mediated mast cell degranulation accompanied by the release of histamine.…”

Inhibitory Effect of Depolymerized Sulfated Galactans from Marine Red Algae on the Growth and Adhesion of Diarrheagenic Escherichia coli

“…ESP and GSP and their corresponding depolymerized products exhibited absorption peaks at 3438, 2935, and 1064 cm −1 , which are characteristic absorptions of -OH, C-H, and C-O, respectively [15]. The peak at 933 cm −1 can be attributed to 3,6-AG (C-O-S) [16]. The most important peaks for ESP and GSP and their depolymerized products are located at approximately 1244 and 1265 cm −1 , respectively, which correspond to the stretching vibration of the ester sulfate groups (S=O) [6,17].…”

Advantages of the polysaccharides from Gracilaria lemaneiformis over metformin in antidiabetic effects on streptozotocin-induced diabetic mice

“…11 Moreover, a sulfated polysaccharide isolated from Gracilaria lemaneiformis showed signicantly higher MW (152.5 kDa) and galactose content (87.49%), but lower sulfate content (11.26%), compared to our results. 12 These differences might be due to various factors, including the different extraction methods and/or different geographical origins of the materials used in the experiment.…”

“…11 Further, polysaccharides from Gracilaria lemaneiformis (GLP) have been found to possess various biological activities such as antioxidant, antimutagenic, anti-food allergic, antitumor and hypoglycemic effects. [10][11][12] However, the effect of GLP on diabetes induced by streptozotocin (STZ) (a naturally occurring chemical to induce toxicity in the insulin-producing pancreatic b cells of mammals), have not been investigated and the underlying mechanisms remained unknown. Further, polysaccharides with good water solubility and relatively low molecular weight (MW) likely possess greater bioactivities.…”