Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

Lee, Dong Gun; Park, Yoonkyung; Kim, Mi Ran; Jung, Hyun Jun; Seu, Young‐Bae; Hahm, Kyung‐Soo; Woo, Eun Rhan

doi:10.1023/b:bile.0000035483.85790.f7

Cited by 108 publications

(58 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Antifungal effects of different HCAAs were tested using Saccharomyces cerevisiae, Trichoderma beigelii, and Candida albicans (Lee et al, 2004), as well as mycorrhizal fungi (Grandmaison et al, 1993). A limited number of reports exists for the effect of HCAAs on phytopathogenic fungi, such as the cereal fungal pathogen Fusarium culmorum (Fattorusso et al, 1999), the causal agent of brown rot in stone fruit, Monilinia fructicola (Venis, 1969), and the Arabidopsis pathogen Alternaria brassicicola (Muroi et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

MATE Transporter-Dependent Export of Hydroxycinnamic Acid Amides

et al. 2016

View full text Add to dashboard Cite

The ability of Arabidopsis thaliana to successfully prevent colonization by Phytophthora infestans, the causal agent of late blight disease of potato (Solanum tuberosum), depends on multilayered defense responses. To address the role of surfacelocalized secondary metabolites for entry control, droplets of a P. infestans zoospore suspension, incubated on Arabidopsis leaves, were subjected to untargeted metabolite profiling. The hydroxycinnamic acid amide coumaroylagmatine was among the metabolites secreted into the inoculum. In vitro assays revealed an inhibitory activity of coumaroylagmatine on P. infestans spore germination. Mutant analyses suggested a requirement of the p-coumaroyl-CoA:agmatine N4-p-coumaroyl transferase ACT for the biosynthesis and of the MATE transporter DTX18 for the extracellular accumulation of coumaroylagmatine. The host plant potato is not able to efficiently secrete coumaroylagmatine. This inability is overcome in transgenic potato plants expressing the two Arabidopsis genes ACT and DTX18. These plants secrete agmatine and putrescine conjugates to high levels, indicating that DTX18 is a hydroxycinnamic acid amide transporter with a distinct specificity. The export of hydroxycinnamic acid amides correlates with a decreased ability of P. infestans spores to germinate, suggesting a contribution of secreted antimicrobial compounds to pathogen defense at the leaf surface.

show abstract

Section: Discussionmentioning

confidence: 99%

MATE Transporter-Dependent Export of Hydroxycinnamic Acid Amides

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Turmeric oil from Curcuma longa (Zingiberaceae) had minimum inhibitory concentrations (MICs) in a range of 229.8-919.2 ppm (Apisariyakul et al, 1995). Furthermore, four phenolic amides, dihydro-N-caffeoyltyramine, trans-N-feruloyloctopamine, trans-Ncaffeoyltyramine, and cis-N-caffeoyltyramine isolated from Lycium chinense were reported to have anti-fungal activity in a range of 5-10 ppm (Lee et al, 2004)…”

Section: Discussionmentioning

confidence: 99%

The Antifungal Activity of Bee Venom against Dermatophytes

Yu¹,

Kim²,

Park³

et al. 2012

Journal of Applied Biological Chemistry

View full text Add to dashboard Cite

The antifungal activities of the bee venom against Trichophyton mentagrophytes and Trichophyton rubrum were determined by using modified broth dilution assay. The most common dermatophytes, named T. mentagrophytes and T. rubrum, were known to cause a variety of cutaneous infections in humans and animals. The bee venom exhibited prominent antifungal activities against the two dermatophytes tested in this investigation. Moreover, the antifungal activities of the bee venom were much stronger than that of fluconazole, one of the commercial antifungal drugs used in the treatment and prevention of superficial and systemic fungal infections. The result suggests that bee venom could be developed as a natural antifungal drug.

show abstract

“…Indeed in GC-MS analysis, methanol-soluble fraction of ethanol-water extract was determined to contain more constituents, which include phenolic, acid, and protein derivatives. Indeed, the phenolic amines, such as tyramine derivative, have already been reported for root bark of Lycium chinense [25]. In methanol-insoluble fraction, only phenolic acids were detected (see Figure S2 in Supplementary Materials).…”

Section: Bark Extractives From Ethanol-water Pretreatmentmentioning

confidence: 71%

Transformation of Sugar Maple Bark through Catalytic Organosolv Pulping

Koumba-Yoya

Stevanović

2017

Catalysts

View full text Add to dashboard Cite

Abstract:The catalytic organosolv pulping of sugar maple bark was performed adopting the concept of forest biorefinery in order to transform bark into several valuable products. Our organosolv process, consisting of pre-extracting the lignocellulosic material followed by pulping with ferric chloride as a catalyst, was applied to sugar maple bark. The pre-extraction step has yielded a mixture of phenolic extractives, applicable as antioxidants. The organosolv pulping of extractives-free sugar maple bark yielded a solid cellulosic pulp (42.3%) and a black liquor containing solubilized bark lignin (24.1%) and products of sugars transformation (22.9% of hemicelluloses), mainly represented by furfural (0.35%) and 5-hydroxymethyl furfural (HMF, 0.74%). The bark cellulosic pulp was determined to be mainly constituted of glucose, with a high residual lignin content, probably related to the protein content of the original bark (containing cambium tissue). The biorefinery approach to the transformation of a solid bark residue into valuable biopolymers (lignin and cellulose) along with phenolic antioxidants from pre-extraction and the HMF derivatives from black liquor (applicable for 2,5-diformylfuran production) is an example of a catalytic process reposing on sustainable engineering and green chemistry concepts.

show abstract

Anti-fungal effects of phenolic amides isolated from the root bark of Lycium chinense

Cited by 108 publications

References 18 publications

MATE Transporter-Dependent Export of Hydroxycinnamic Acid Amides

MATE Transporter-Dependent Export of Hydroxycinnamic Acid Amides

The Antifungal Activity of Bee Venom against Dermatophytes

Transformation of Sugar Maple Bark through Catalytic Organosolv Pulping

Contact Info

Product

Resources

About