Anti-ganglioside Antibodies in Guillain-Barré Syndrome; Useful Diagnostic Markers as Well as Possible Pathogenetic Factors

Kusunoki, Susumu

doi:10.2169/internalmedicine.42.457

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Although the precise targets for immune attack in AIDP remain unknown, accumulating evidence suggest that the antibodies may bind to glycolipids and gangliosides enriched in Schwann cell membranes. These include LM1, SGPG and GM1 ganglioside, identifi ed in a small proportion of cases (Kusunoki 2003 ).…”

Section: Guillain-barré Syndromementioning

confidence: 99%

Glycoconjugates and Neuroimmunological Diseases

Willison

2014

Advances in Neurobiology

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A wide range of neuroimmunological diseases affect the central and peripheral nervous systems. These disorders are caused by autoimmune attack directed against structurally and functionally diverse nervous system antigens. One such category comprises peripheral nervous system (PNS) diseases, termed peripheral neuropathies, in which the target antigens for autoantibody-directed nerve injury are glycan structures borne by glycoproteins and glycolipids, particularly gangliosides that are concentrated in peripheral nerve. The archetypal PNS disorder is the acute paralytic disease, Guillain-Barré syndrome (GBS) in which autoantibodies against glycolipids arise in the context of acute infections that precede the clinical onset, notably Campylobacter jejuni enteritis. In addition, several chronic autoimmune neuropathies are associated with IgM antibodies directed against nerve glycans including sulphated glucuronic acid epitopes present on myelin-associated glycoprotein and sulphated glucuronyl paragloboside, a range of disialylated gangliosides including GD1b and GD3, and GM1 ganglioside. This chapter describes the immunological, pathological and clinical features of these disorders in the context of our broader knowledge of the glycobiology underpinning this neuroimmunological field.

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Section: Guillain-barré Syndromementioning

confidence: 99%

Glycoconjugates and Neuroimmunological Diseases

Willison

2014

Advances in Neurobiology

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“…13,27,28 To determine normative values for magnetic stimulation, control data were obtained from 12 healthy individuals (ages 21 to 50 years, six men and six women) without any neurologic symptoms or signs. All subjects gave informed consent.…”

mentioning

confidence: 99%

Activity-dependent conduction block in multifocal motor neuropathy

Nodera

Bostock²,

Izumi³

et al. 2006

Neurology

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Anti-ganglioside Antibodies in Peripheral Nerve Pathology

Willison

2018

Methods in Molecular Biology

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Anti-ganglioside antibodies are principally associated with autoimmune peripheral neuropathies. In these disorders, immune attack is inadvertently directed at peripheral nerve by autoantibodies that target glycan structures borne by glycolipids, particularly gangliosides concentrated in nerve myelin and axons. The most thoroughly studied disorder is the acute paralytic disease, Guillain-Barré syndrome (GBS) in which IgG autoantibodies against gangliosides arise following acute infections, notably Campylobacter jejuni enteritis. Additionally, chronic autoimmune neuropathies are associated with IgM antibodies directed against many glycolipids including gangliosides. This introductory chapter briefly summarizes the immunological and pathological features of these disorders, focusing on the methodological development of antibody measurement and of animal models.

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Anti-ganglioside Antibodies in Guillain-Barré Syndrome; Useful Diagnostic Markers as Well as Possible Pathogenetic Factors

Cited by 4 publications

References 17 publications

Glycoconjugates and Neuroimmunological Diseases

Glycoconjugates and Neuroimmunological Diseases

Activity-dependent conduction block in multifocal motor neuropathy

Anti-ganglioside Antibodies in Peripheral Nerve Pathology

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