Anti-ganglioside antibodies-mediated leptospiral meningomyeloencephalopolyneuritis

Lepur, Dragan; Himbele, J; Klinar, Igor; Vranjican, Zoran; Baršić, Bruno

doi:10.1080/00365540601034816

Cited by 10 publications

(4 citation statements)

References 8 publications

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“…His mental status improved significantly after 2 plasmapheresis sessions. It is hypothesized that antibody-mediated damage to the nervous system could lead to encephalopathy, and prompt neurological recovery following plasmapheresis 5 with no recovery of the kidney function.…”

Section: Discussionmentioning

confidence: 99%

Atypical Renal Presentation in Severe Leptospirosis

Małecki

Gołembiewska

Muraszko

et al. 2019

Kidney International Reports

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Section: Discussionmentioning

confidence: 99%

Atypical Renal Presentation in Severe Leptospirosis

Małecki

Gołembiewska

Muraszko

et al. 2019

Kidney International Reports

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“…These include cytomegalovirus and leptospirosis. 19,20 An expanding list of antecedent infections with acute transverse myelitis is now recognized, which includes measles, mumps, varicella, Mycoplasma pneumoniae, herpes virus, hepatitis viruses, and Listeria monocytogenes. 21,22 Systematic studies on large number of patients are required to look for the association of antiganglioside antibodies and acute transverse myelitis caused by any of these agents.…”

Section: Discussionmentioning

confidence: 99%

Childhood Acute Transverse Myelitis: Clinical Profile, Outcome, and Association With Antiganglioside Antibodies

et al. 2009

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Prospectively, in 15 children the association of acute transverse myelitis with Campylobacter jejuni infection and antiganglioside antibodies was studied. The clinical profile, radiological findings, and treatment outcome in these children were analyzed. Stool culture and serology for Campylobacter jejuni and antiganglioside antibodies were tested. In all, 15 age- and sex-matched healthy controls were tested for evidence of Campylobacter jejuni infection and antiganglioside antibodies. Anti-GM1 antiganglioside immunoglobulin G antibodies were found in 46% of patients with acute transverse myelitis versus 6.6% of controls (P = .035). Evidence of Campylobacter jejuni infection was absent in both the groups. The magnetic resonance imaging revealed longitudinally extensive lesions in majority. All children underwent intravenous high-dose corticosteroid treatment. At 1-year follow-up, 8 children had recovered completely, whereas 3 were nonambulatory. Bladder disturbances persisted in 7. The significance of these findings and the possible role antiganglioside antibodies may play in acute transverse myelitis pathophysiology is discussed.

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“…2,18,19 Antiganglioside antibodies were detected in a 69-year-old white man with neurological complications of leptospirosis presenting with meningomyeloencephalopolyneuritis and nephrotic syndrome. 20 Treatment of severe leptospirosis patients is supportive management and use of appropriate antibiotics. Corticosteroid therapy is controversial since most cases of acute leptospirosis resolve spontaneously.…”

Section: Discussionmentioning

confidence: 99%

Leptospirosis with transient paraparesis and thrombocytopenia: A case report

Wang

Huang

et al. 2012

Journal of Microbiology, Immunology and Infection

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Leptospirosis is the most widespread zoonosis in the world. We present an unusual case of leptospirosis in a 44-year-old man with severe thrombocytopenia and transient paraparesis. The diagnosis of leptospirosis was confirmed by blood nested polymerase chain reaction, seroconversion of Leptospira IgM and the microscopic agglutination test. Nerve conduction studies were suggestive of early polyneuropathy involving the right peroneal nerve and bilateral sural nerves. Peripheral nerve palsy is a potential clinical feature of leptospirosis.

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Anti-ganglioside antibodies-mediated leptospiral meningomyeloencephalopolyneuritis

Abstract: BACKGROUND

Cited by 10 publications

References 8 publications

Atypical Renal Presentation in Severe Leptospirosis

Atypical Renal Presentation in Severe Leptospirosis

Childhood Acute Transverse Myelitis: Clinical Profile, Outcome, and Association With Antiganglioside Antibodies

Leptospirosis with transient paraparesis and thrombocytopenia: A case report

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