Anti-gastritic Effects of Magnolol and Honokiol from the Stem Bark of Magnolia obovata

Abstract

− In this study we investigated the effects of Magnolia Bark (MB) extract and its constituents, such as honokiol and magnolol, on gastritis in rats and the growth of human gastric cancer cells. The MB extract, honokiol, and magnolol showed the acid-neutralizing capacities, the antioxidant activities, and the inhibitory effect on the growth of Helicobacter pylori (H. pylori.) at the dose of 50 µg/ml and over, which is equivalent to that of ampicillin (100 µg/ml). Honokiol and magnolol had no significant cytotoxicity to human gastric caner cells (AGS and SNU638). However, the MB extract had cytotoxic activity against AGS gastric cancer cell. The MB extract, honokiol, and magnolol significantly inhibited HCl·ethanol-induced gastric lesions without clear change of mucus content. In pylorus ligated rats, honokiol significantly decreased the volume of gastric secretion and gastric acid output, and increased the pH. Magnolol increased the mucus content to almost the same as the control group at oral doses of 50 mg/kg. Therefore, we could guess that antigastritic action of honokiol and magnolol may be associated with the antioxidant activities, acid-neutralizing capacities, inhibition of secretion in gastric acid, and anti-H. pylori action. From these results, we could suggest that MB extract and its constituents, such as honokiol and magnolol, may be useful for the treatment and/or protection of gastritis.

Peroxyl radical scavenging capacity of extracts and isolated components from selected medicinal plants

“…Kim). The methods for isolation and purification of components in M. obovata (magnolol, honokiol, syringin), P. lobata (daidzein, puerarin, genistein), and S. miltiorrhiza (tanshinone I, crypto tanshinone, 15-16-dihydrotanshinone) were described elsewhere (Park et al, 2007;Cho et al, 2008;Jeon et al, 2008). All the other reagents and chemicals used in this study were of analytical reagent grade or better.…”

Antimicrobial Activity and Cytotoxic Effects of Magnolia dealbata and its Active Compounds

“…Therefore, it is necessary to identify novel antimicrobial agents from additional sources including plants. [2][3][4][5][6]. However, most of these antimicrobial effects have been tested on antibiotic-sensitive microorganisms.…”

“…However, most of these antimicrobial effects have been tested on antibiotic-sensitive microorganisms. Honokiol (HK) and magnolol (MG) (Figure 1), the major bioactive constituents of Magnolia species [7], have antimicrobial effects against drug-sensitive bacteria and fungi [4,[8][9][10][11]. Clavibacter michiganensis subsp michiganensis is the cause of the most important disease of tomato (Lycopersicon esculentum), which causes large economic losses worldwide [12].…”

Cytotoxicity of Neolignans from Magnolia obovata Fruits

“…This plant has been used for the treatment of fever, headache, diarrhea, anxiety, and relief of asthma in Chinese medicine. M. obovata has been reported to have anti-platelet (Pyo et al, 2002a;2002b), anti-gastritic (Cho et al, 2008), anti-inflammatory (Tzeng and Liu, 2004;Seo et al, 2013) and cytotoxic (Min et al, 2008;Youn et al, 2008) activities. So far, magnolol, honokiol, and obovatol have been reported to show cytotoxic activities against human cancer cells (Kim and Ryu, 1999;Lin et al, 2001;Yang et al, 2003;Youn et al, 2008;Patrick et al, 2011).…”