Anti-GM1 ganglioside antibodies, neuron specific enolase and interleukin 10 concentrations as potential markers of autonomic nervous system impairment in celiac disease - preliminary findings

Przybylska-Feluś, Magdalena; Zwolińska–Wcisło, Małgorzata; Piątek-Guziewicz, Agnieszka; Furgała, Agata; Sałapa, Kinga; Mach, Tomasz

doi:10.20452/pamw.3512

Cited by 5 publications

(9 citation statements)

References 11 publications

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“…66,67 Also celiac disease (CD), which can have a variety of neurological manifestations, e.g cerebellar ataxia, peripheral neuropathy, epilepsy and depression 68,69 , has been associated with anti-GM1 antibodies. 70 The trigger that induces the generation of AGAs is not known. However, it is possible that the formation of complexes between gliadin and GM1 leads to the generation of anti-GM1 antibodies as a "side product".…”

Section: Immune-mediated Diseasesmentioning

confidence: 99%

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Physiology of gangliosides and the role of antiganglioside antibodies in human diseases

2020

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Gangliosides are structurally and functionally polymorphic sialic acid containing glycosphingolipids that are widely distributed in the human body. They play important roles in protecting us against immune attacks, yet they can become targets for autoimmunity and act as receptors for microbes, like the influenza viruses, and toxins, such as the cholera toxin. The expression patterns of gangliosides vary in different tissues, during different life periods, as well as in different animals. Antibodies against gangliosides (AGA) can target immune attack e.g., against neuronal cells and neutralize their complement inhibitory activity. AGAs are important especially in acquired demyelinating immune-mediated neuropathies, like Guillain-Barré syndrome (GBS) and its variant, the Miller-Fisher syndrome (MFS). They can emerge in response to different microbial agents and immunological insults. Thereby, they can be involved in a variety of diseases. In addition, antibodies against GM3 were found in the sera of patients vaccinated with Pandemrix®, who developed secondary narcolepsy, strongly supporting the autoimmune etiology of the disease.

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Section: Immune-mediated Diseasesmentioning

confidence: 99%

“…Przybylska 70 HIV (asymptomatic patients) GM2, GD1a, GQ1b Nicolae 153 Parvovirus B19 GD1b Sequeira 123 Type I diabetes GM1, GM2, GM3, GD1b, GD1a Lucchetta 73 Secondary narcolepsy GM3, GM4 Saariaho 137 Guillain-Barré syndrome AIDP: GT1b AMAN: GM1, GM1b, GD1a, GalNac-GD1a AMSAN: GM1, GM1b, GD1a MF: GQ1b BE: GQ1b…”

Section: Gm1mentioning

confidence: 99%

Physiology of gangliosides and the role of antiganglioside antibodies in human diseases

2020

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“…The presence of anti-ganglioside antibodies in celiac disease patients with peripheral neuropathy was first reported by our team in 2002 [ 92 ]. A number of subsequent studies have confirmed the presence of various anti-ganglioside antibodies in conjunction with neurologic symptoms in celiac disease patients and those with immune reactivity to gluten [ 93 , 94 , 95 , 96 , 97 , 98 , 99 ]. At least one study has found that anti-ganglioside antibody reactivity responds to the exclusion of gluten from diet in a significant subset of patients with celiac disease [ 96 ].…”

Section: Gangliosidesmentioning

confidence: 99%

Autoantibodies in the Extraintestinal Manifestations of Celiac Disease

Uhde

Green

et al. 2018

Nutrients

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Increased antibody reactivity towards self-antigens is often indicative of a disruption of homeostatic immune pathways in the body. In celiac disease, an autoimmune enteropathy triggered by the ingestion of gluten from wheat and related cereals in genetically predisposed individuals, autoantibody reactivity to transglutaminase 2 is reflective of the pathogenic role of the enzyme in driving the associated inflammatory immune response. Autoantibody reactivity to transglutaminase 2 closely corresponds with the gluten intake and clinical presentation in affected patients, serving as a highly useful biomarker in the diagnosis of celiac disease. In addition to gastrointestinal symptoms, celiac disease is associated with a number of extraintestinal manifestations, including those affecting skin, bones, and the nervous system. Investigations of these manifestations in celiac disease have identified a number of associated immune abnormalities, including B cell reactivity towards various autoantigens, such as transglutaminase 3, transglutaminase 6, synapsin I, gangliosides, and collagen. Clinical relevance, pathogenic potential, mechanism of development, and diagnostic and prognostic value of the various identified autoantibody reactivities continue to be subjects of investigation and will be reviewed here.

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“…In those preliminary data, Przybylska-Feluś et al 14 reported that celiac subjects presented with a higher concentration of anti-GM1 antibodies and IL-10 in comparison with the control group. The difference in NSE levels was not significantly higher in patients with celiac disease.…”

Section: Editorialmentioning

confidence: 88%

“…The paper by Przybylska-Feluś et al, 14 published in the October issue of the Polish Archives of Internal Medicine (Pol Arch Med Wewn) discusses a very important issue concerning the different clinical manifestations of celiac disease, especially neurologic conditions. In this interesting preliminary report, the authors evaluated the prevalence of antiganglioside M1 (anti-GM1) antibodies as well as the concentrations of NSE and IL-10 in patients with celiac disease without neurologic symptoms and in the control group of healthy subjects.…”

Section: Editorialmentioning

confidence: 99%

Markers of autonomic nervous system impairment in celiac disease: we know the questions to ask but we still do not have answers

Rydzewska¹

2016

Polish Archives of Internal Medicine

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Anti-GM1 ganglioside antibodies, neuron specific enolase and interleukin 10 concentrations as potential markers of autonomic nervous system impairment in celiac disease - preliminary findings

Cited by 5 publications

References 11 publications

Physiology of gangliosides and the role of antiganglioside antibodies in human diseases

Physiology of gangliosides and the role of antiganglioside antibodies in human diseases

Autoantibodies in the Extraintestinal Manifestations of Celiac Disease

Markers of autonomic nervous system impairment in celiac disease: we know the questions to ask but we still do not have answers

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