Anti-GM2, -GD1a and -GD1b positive purely isolated facial diplegia

Vachalová, Ivana; Golden, Valerie; Heckmann, Josef G.

doi:10.1016/j.clineuro.2014.03.025

Cited by 3 publications

(2 citation statements)

References 5 publications

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“…In addition, they demonstrate the positivity of serum IgM anti‐ganglioside antibody to GM2. With the exception of one case report of a patient with FDp who was positive for some anti‐ganglioside antibodies, including IgG GM2 (Vachalova et al ., ) , there have been no other reports of positive anti‐ganglioside antibodies in this variant.…”

Section: Discussionmentioning

confidence: 76%

When is facial diplegia regarded as a variant of Guillain‐Barré syndrome?

Kim

Sohn

et al. 2015

J Peripheral Nervous Sys

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A variant of Guillain-Barré syndrome (GBS) with predominant manifestation of facial diplegia (FD) has been described recently. This study aimed to characterize and determine the incidence of this FD-predominant GBS variant. The clinical and serological information of 900 consecutive patients were reviewed. In total, eight patients were identified between January 2007 and December 2010 as having FD accompanied by some features of GBS. These features were subjective sensory symptoms such as distal paresthesia (7/8, 88%), albumin-cytological (A/C) dissociation (7/8, 88%), antecedent infection (6/8, 75%), and minor nerve conduction study (NCS) abnormalities (5/7, 71%). One patient presented with the typical NCS feature of demyelinating neuropathy. Only two patients exhibited areflexia (2/8, 25%). None of the patients possessed any anti-ganglioside antibodies; however, the serum of two patients was positive for anti-mycoplasma antibody (2/6, 33%). FD variant of GBS occurred in less than 1% of our dataset. FD can be a regional variant of GBS when it is accompanied by supporting features, such as subjective tingling, A/C dissociation, and minor NCS abnormalities.

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Section: Discussionmentioning

confidence: 76%

When is facial diplegia regarded as a variant of Guillain‐Barré syndrome?

Kim

Sohn

et al. 2015

J Peripheral Nervous Sys

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“…Seit einigen Jahren können Gangliosid-Autoantikörper laborchemisch bestimmt werden, aber bisher wurden sie bei Hirnnerven-Läsionen äußerst selten beschrieben [1][2][3][4]. In dieser Kasuistik diskutieren wir 5 Fälle von immunpathogenen Hirnnerven-Schäden mit Gangliosid-Autoantikörpern.…”

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Isolierte Hirnnerven-Läsionen

Bánáti

Vachalová

Vynogradova

et al. 2015

Dtsch med Wochenschr

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Antiganglioside, antiganglioside-complex, and antiglycolipid-complex antibodies in immune-mediated neuropathies

Goodfellow

Willison²

2016

Current Opinion in Neurology

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Antibodies against single ganglioside species remain diagnostically useful in routine clinical practice. Antibodies against ganglioside complexes, or gangliosides and other glycolipid complexes, are emerging as useful markers of various clinic features and pathological subtypes; however, the precise associations remain to be fully delineated and confirmed. The antibody-complex detection methods are rapidly evolving but in most centres are not yet available in routine clinical practice.

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Anti-GM2, -GD1a and -GD1b positive purely isolated facial diplegia

Cited by 3 publications

References 5 publications

When is facial diplegia regarded as a variant of Guillain‐Barré syndrome?

When is facial diplegia regarded as a variant of Guillain‐Barré syndrome?

Isolierte Hirnnerven-Läsionen

Antiganglioside, antiganglioside-complex, and antiglycolipid-complex antibodies in immune-mediated neuropathies

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