Anti-Gravity Treadmill Training for Freezing of Gait in Parkinson’s Disease

Baizabal‐Carvallo, José Fidel; Alonso-Juárez, Marlene; Fekete, Róbert

doi:10.3390/brainsci10100739

Cited by 8 publications

(4 citation statements)

References 22 publications

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“…Physiotherapy is gradually emerging as therapeutic approach for FOG treatment. A recent study carried out antigravity treadmill training to improve the daily life activity ability of FOG patients (Baizabal‐Carvallo et al., 2020 ). In another examination of FOG motor networks, a novel device for deep brain electrical stimulation was used, which recorded the neural activity of the subthalamic nucleus.…”

Section: Discussionmentioning

confidence: 99%

Clinical features and related factors of freezing of gait in patients with Parkinson's disease

et al. 2021

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Background: Freezing of gait (FOG) is a disabling paroxysmal gait disorder that prevents starting or resuming walking, which seriously negatively affects patients' quality of life (QOL). The diagnosis and treatment of FOG remain a huge medical challenge.The purpose of this study was to explore the clinical characteristics and related factors of FOG in patients with Parkinson's disease (PD). Methods:The motor and nonmotor symptoms of a total number of 77 PD patients were evaluated. Patients with or without FOG were defined as a score ≥1 in the new freezing of gait questionnaire (NFOG-Q). A comparative study between patients with and without FOG was conducted. Results:In this investigation, the prevalence of FOG was 48%. The patients with FOG had longer disease duration, higher Hoehn-Yahr stage (H-Y stage), higher dose of dopaminergic agents, and higher nonmotor and motor symptom scores. A significant positive correlation was found between the NFOG-Q score and the H-Y stage, PIGD subscore, PDQ-39, and the attention/memory in the nonmotor symptoms assessment scale (NMSS) subitem (r > 0.5, p < .05). The binary logistic regression analysis showed that the higher H-Y stage, higher rigidity subscore and Unified Parkinson's Disease Rating Scale II (UPDRS II) score, and UPDRS III score were significantly correlated with the occurrence of FOG (p < .05). In the analysis of the frequency of FOG, the prevalence of FOG in H-Y stage was higher in the middle and late stages, and the prevalence of FOG increased with the increase in PDQ-39 scores. Conclusion:The severity of FOG was significantly positively correlated with the H-Y stage, PIGD subscore, PDQ-39 score, and attention/memory score. Based on our findings, we conclude that the clinical characteristics of rigidity can be used as a potential predictor of FOG.

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Section: Discussionmentioning

confidence: 99%

Clinical features and related factors of freezing of gait in patients with Parkinson's disease

et al. 2021

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“…Physical rehabilitation is acknowledged to be crucial ( Cosentino et al, 2020 ) and there are a number of approaches that have been applied to FOG in the research setting. These include action observation training ( Pelosin et al, 2010 , 2018 ; Agosta et al, 2017 ; Mezzarobba et al, 2020 ), treadmill training ( Hong and Earhart, 2008 ; Frazzitta et al, 2009 ; Lo et al, 2010 ; Barbe et al, 2013 ; Picelli et al, 2016 ; Baizabal-Carvallo et al, 2020 ; Bekkers et al, 2020 ; Seuthe et al, 2020 ), aquatic obstacle training ( Zhu et al, 2018 ), curved walking training ( Cheng et al, 2017 ), supervised slackline training ( Santos et al, 2017 ), as well as home based exercises ( Canning et al, 2015 ). In contrast, general exercises and standard physiotherapy do not seem to be effective for the treatment of FOG ( Miller et al, 2020 ).…”

Section: Non-pharmacological Approachesmentioning

confidence: 99%

Future Therapeutic Strategies for Freezing of Gait in Parkinson’s Disease

Cui

Lewis

2021

Front. Hum. Neurosci.

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Freezing of gait (FOG) is a common and challenging clinical symptom in Parkinson’s disease. In this review, we summarise the recent insights into freezing of gait and highlight the strategies that should be considered to improve future treatment. There is a need to develop individualised and on-demand therapies, through improved detection and wearable technologies. Whilst there already exist a number of pharmacological (e.g., dopaminergic and beyond dopamine), non-pharmacological (physiotherapy and cueing, cognitive training, and non-invasive brain stimulation) and surgical approaches to freezing (i.e., dual-site deep brain stimulation, closed-loop programming), an integrated collaborative approach to future research in this complex area will be necessary to systematically investigate new therapeutic avenues. A review of the literature suggests standardising how gait freezing is measured, enriching patient cohorts for preventative studies, and harnessing the power of existing data, could help lead to more effective treatments for freezing of gait and offer relief to many patients.

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“…Antigravity treadmill was developed by the National Aeronautics and Space Administration (NASA) to train astronauts for postural and movement control in space [ 12 ]. Inside an antigravity treadmill machine, patients can walk with reduced weight load and intra-articular pressure in the lower limbs; therefore, it is an appropriate gait training approach for patients with muscle weakness [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

“…Berthelsen et al [ 14 ] reported that early gait training using antigravity treadmill improved postural stability and gait abilities in patients with muscular dystrophy. Baizabal-Carvallo et al [ 12 ] reported that antigravity treadmill training improved gait freeze and mobility in patients with Parkinson’s disease. However, research on the effects of antigravity treadmill in stroke patients is rare.…”

Section: Introductionmentioning

confidence: 99%

Effect of Antigravity Treadmill Gait Training on Gait Function and Fall Risk in Stroke Patients

Lee

et al. 2022

Ann Rehabil Med

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Objective To investigate the effect of antigravity treadmill gait training (AGT) on gait function, balance, and fall risk in stroke patients.Methods This study included 30 patients with stroke (mean age, 73 years). All subjects were randomly divided into two groups. The intervention group (n=15) performed AGT for 20 minutes, five times per week for 4 weeks. The control group (n=15) received conventional gait training for the same duration. To assess fall risk, the Tinetti Performance-Oriented Mobility Assessment (POMA) was measured. The Berg Balance Scale (BBS), Timed Up and Go test (TUG), and 10-m walk test (10mWT) were measured to assess dynamic balance. All scales were measured before intervention (T0) and at 4 weeks (T1) and 12 weeks (T2) after intervention.Results Results showed that the total POMA score, BBS, and 10mWT scores improved significantly (p<0.05) at T1 and T2 in both groups. The POMA gait score (4.20±1.37 at T1, 4.87±1.36 at T2) and TUG (4.52±4.30 at T1, 5.73±4.97 at T2) significantly improved (p<0.05) only in the intervention group. The changes in total POMA score and BBS of the intervention group (7.20±2.37, 7.47±3.07) improved more significantly (p<0.05) between T0 and T2 than the control group (2.53±2.10, 2.87±2.53).Conclusion Our study showed that AGT enhances dynamic balance and gait speed and effectively lowers fall risk in stroke patients. Compared to conventional gait therapy, AGT would improve gait function and balance in stroke patients more effectively.

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Anti-Gravity Treadmill Training for Freezing of Gait in Parkinson’s Disease

Cited by 8 publications

References 22 publications

Clinical features and related factors of freezing of gait in patients with Parkinson's disease

Clinical features and related factors of freezing of gait in patients with Parkinson's disease

Future Therapeutic Strategies for Freezing of Gait in Parkinson’s Disease

Effect of Antigravity Treadmill Gait Training on Gait Function and Fall Risk in Stroke Patients

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