Anti-HBc screening in Indian blood donors: Still an unresolved issue

Dhawan, Hari Krishan; Marwaha, Neelam; Sharma, Ratti Ram; Chawla, Yogesh; Thakral, Beenu; Saluja, Karan; Sharma, Sanjeev Kumar; Thakur, Manish; Jain, Ashish

doi:10.3748/wjg.14.5327

Cited by 40 publications

(39 citation statements)

References 14 publications

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“…The varied prevalence of the core positivity has been reported in Indian studies. Dhawan et al, [5] from Chandigarh reported a core positive rate of 8.4% which was comparable to our data, whereas a high positivity rate of 18.3% was observed by Bhattacharya et al, [6] in West Bengal [Table /Fig-4]. …”

Section: Discussionsupporting

confidence: 75%

The Prevalence of the Hepatitis B Core Antibody and the Occult Hepatitis B Infection Among Voluntary Blood Donors in Chennai, India

M¹

2012

JCDR

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Introduction:The infection with the Hepatitis B Virus (HBV) is a global health problem which affects 2 billion people worldwide. In India, the prevalence of the Hepatitis B infection is 4% in the general population. The prevalence of the HBV infection in voluntary blood donors is 1-3%. It has been reported that the viraemia continues even after the clinical recovery from the acute HBV infection. Some blood donors who were negative for the surface antigen but positive for the core antibody have been reported to transmit HBV, leading to acute hepatitis. This study was done to determine the seroprevalence of the hepatitis B core antibody in voluntary blood donors in Chennai, India. Conclusion:If a routine screening of the sera for the core antibody is not done, the low-level HBV viraemia may not be identified. The absence of the surface antigen in the blood of apparently healthy individuals may not be sufficient to ensure the lack of the circulating virus.MahesWari K s, arun r , aruMugaM P

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Section: Discussionsupporting

confidence: 75%

The Prevalence of the Hepatitis B Core Antibody and the Occult Hepatitis B Infection Among Voluntary Blood Donors in Chennai, India

M¹

2012

JCDR

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“…Earlier findings suggest that recovery from acute hepatitis B virus infection may not result in complete virus elimination; rather, the immune system keeps the virus at a very low level, leading to occult hepatitis B infection [20].…”

Section: Discussionmentioning

confidence: 99%

“…Studies from other parts of India reported occult HBV infection ranging from 21% in Kolkata (eastern India), 20.87% in New Delhi (northern India) to 0% in Chandigarh (north-western India) [18][19][20].…”

Section: Discussionmentioning

confidence: 99%

Occult hepatitis B infection among individuals belonging to the aboriginal Nicobarese tribe of India

Bhattacharya

Roy

et al. 2014

J Infect Dev Ctries

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Introduction: The long-lasting persistence of hepatitis B virus (HBV) genomes in the liver (with or without detectable HBV DNA) of individuals with negative for HBV surface antigen (HBsAg) is termed occult HBV infection (OBI). The present study is a part of the follow up on efficacy of vaccination, 10 years post inception, and was designed to understand the prevalence of Occult Hepatitis B infection (OBI) among the aboriginal Nicobarese tribal community. Methodology: A total of 612 serum samples were collected and tested for various markers including HBsAg, Anti-HBs, Anti-HBc and HBV DNA. Part of S gene of the extracted HBV DNA was amplified by nested PCR. The amplified products were then subjected to sequencing. Genotyping was performed on the basis of phylogenetic relationship along with representative reference sequences from different sub genotypes. Results: The study revealed OBI in 11.1% of the people belonging to the Nicobarese tribe. Phylogenetic analysis showed only one genotype, HBV/D circulating among the Nicobarese population with ayw3 was the major serotype detected. Single or multiple amino acids substitutions were found in 5 of 34 samples (14.7%) which includes I110T, P120T, P/T127I, A128P, M133L and G159V. Conclusions: The detection of OBI among these aboriginal tribes is of great concern and stresses the need for the continuous surveillance as it may contribute to the progression of liver disease to a more advanced stage.

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“…22 In the study from Behrampur, Ganjam in Orissa, about 30.1% of total donations (220 of 729) was anti HBc positive indicating a very high rate of exposure to HBV infection among the blood donors from this region. Studies from other parts of India reported that the prevalence of anti HBV core antibody ranging from 21% in Kolkata (Eastern India), 20.9% in New Delhi (Northern India) to 8.4% in Chandigarh (Northwestern India).…”

Section: Resultsmentioning

confidence: 99%

Prevalence of anti-HBc total positivity in an impoverished Urban Community in Banglades

Ghosh

Nath

et al. 2018

Bangladesh Med Res Counc Bull

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The infection with the Hepatitis B virus (HBV) is a global health problem. Hepatitis B virus (HBV) infections are rapidly spreading in developing countries due to the lack of health education, poverty, illiteracy and Hepatitis B vaccination. No widespread population based data of HBV is available in the country. So, a population-based serological survey was done to determine the prevalence of the Hepatitis B core antibody total (IgM+IgG) in an impoverished Urban Community in Dhaka, Bangladesh. A descriptive cross sectional study was conducted among 384 healthy individuals and age between 18-60 years from the urban slum in Dhaka city. The study was implemented through collaboration with Shaheed Suhrawardy Medical College, Dhaka from January 2013 to June 2013. The study participants were selected through systematic sampling procedure and blood samples tested for anti-HBc. Anti-HBc estimations were carried out by VITROS Immune diagnostic assay. The study was obtained ethical permission from Bangladesh Medical Research Council (BMRC) and every participant was informed regarding the study, and written informed consent was taken. Among the 384 respondents, 183(47.6%) individuals were positive for the core antibody of hepatitis B virus (anti-HBc). The anti HBc positive group consisted almost of equal number of male 93, (24.2%) and female 90 (23.4%). There was a significantly increasing prevalence of the core antibody among young adults and middle age of the respondents (28.7%). Major risk factors for exposure to Hepatitis B appeared to be ear-nose-body piercing, Circumcision by Hajam, unsafe blood transfusion and unsterile dental intervention. High prevalence of hepatitis B core antibody (47.6%) indicates that the members of this urban community are highly exposed to hepatitis B virus.

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Anti-HBc screening in Indian blood donors: Still an unresolved issue

Abstract: anti-HBc screening and discarding large number of blood units versus considering ID NAT (Individual donor nuclic acid testing) needs to be assessed.

Cited by 40 publications

References 14 publications

The Prevalence of the Hepatitis B Core Antibody and the Occult Hepatitis B Infection Among Voluntary Blood Donors in Chennai, India

The Prevalence of the Hepatitis B Core Antibody and the Occult Hepatitis B Infection Among Voluntary Blood Donors in Chennai, India

Occult hepatitis B infection among individuals belonging to the aboriginal Nicobarese tribe of India

Prevalence of anti-HBc total positivity in an impoverished Urban Community in Banglades

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