anti-HCoV: A web resource to collect natural compounds against human coronaviruses

Abstract

Background . A novel coronavirus, the SARS-CoV2, was revealed to be the cause of COVID19, the pandemic disease that already provoked more than 555.324 deaths in the world (July 10, 2020). No vaccine treatment has been defined against SARS-CoV2 or other human coronaviruses (HCoVs), including those causing epidemic infections, neither appropriate strategies for prevention and care are yet officially suggested. Scope and approach . We reviewed scientific literature on natural compounds that were defined as potentially effective against human coronaviruses. Our desk research identified non-chemically modified natural compounds that were shown (in vitro) and/or predicted (in silico) to act against one or more phases of human coronaviruses cell cycle. We selected all available information, merged and annotated the data to define a comprehensive list of natural compounds, describing their chemical classification, the source, the action, the specific target in the viral infection. Our aim was to collect possible compounds for prevention and care against human coronaviruses. Key findings and conclusions . The definition of appropriate interventions against viral diseases need a comprehensive view on the infection dynamics and on necessary treatments. Viral targeting compounds to be exploited in food sciences could be of relevant interest to this aim. We collected 174 natural compounds showing effects against human infecting coronaviruses, providing a curated annotation on actions and targets. The data are available in anti-HCoV , a web accessible resource to be exploited for testing and in vivo trials. The website is here launched to favour a community based cooperative effort to call for contribution and expand the collection. To be ready to fight.

Ethnobotanical survey on plants used by traditional healers to fight against COVID-19 in Fez city, Northern Morocco

“…Therewith, the pharmaceutical industry and scientific research are focusing on exploration of natural products particularly, MAPs producing several bioactive molecules approved effective against viral infections, including those from coronaviruses, enterovirus, hepatitis B, hepatitis C, herpes simplex virus (HSV), human immunodeficiency (HIV), and influenza viruses (IFV) (Monticolo et al 2020).…”

Contemporary Approaches to the Discovery and Development of Broad-Spectrum Natural Product Prototypes for the Control of Coronaviruses

“… 10 However, the catalytic domains of the proteins responsible for RNA synthesis and replication are highly conserved ( Figure 1 ). 11 , 12 These proteins present attractive targets for the identification of drugs active across the entire genus Betacoronavirus . The application of computer-aided drug design tools allows for the inexpensive and rapid evaluation of NP structures in published databases and the scientific literature for in silico screening.…”

Computational Approaches for Cancer-Fighting: From Gene Expression to Functional Foods

“…A healthy eating pattern is mainly based on foods that have balanced amounts of good quality nutrients (vegetables, fiber-rich legumes, fruits and whole grains), and on limited amounts of red and processed meats, sugarsweetened beverages, highly processed foods and refined grain products [2]. In addition, specific bioactive compounds, such as sterols, indoles and phenols, naturally present in many foods, mainly in vegetables and fruits, are known to enrich food quality [12], acting as protective, preventing and caring agents in inflammation [13,14], disease [15,16], infections [17,18] and in chronic diseases such as cancer [19,20]. Indeed, it has been shown that improved diet quality reduces the risk of cancer deaths from 11% to 23% [21].…”