Anti–Heat Shock Protein 70 Antibodies in Meniere's Disease

Rauch, Steven D.; Zurakowski, David; Bloch, Donald B.; Bloch, Kurt J.

doi:10.1097/00005537-200009000-00020

Cited by 34 publications

(26 citation statements)

References 49 publications

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“…It has been suggested that a subgroup of patients with symptoms of Meniere disease may share a common pathophysiology with AIED. This association is based on studies that have noted that approximately onethird of patients with Meniere disease may have a positive Western blot assay for anti-HSP-70 antibodies [28,29]. However, this finding was not supported by a recent study, in which the commercially available assay was used [30].…”

Section: Differential Diagnosismentioning

confidence: 98%

Autoimmune inner ear disease

Ruckenstein

2004

Current Opinion in Otolaryngology & Head and Neck Surgery

133

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The original enthusiasm that was generated by the concept that immune-mediated mechanisms may mediate reversible forms of inner ear pathology has been tempered by the realities conveyed by scientific research. The pathophysiology of AIED is still not well understood. Multiple potential mechanisms have been identified that can result in immune-mediated inner ear pathology. The diagnosis of AIED is based on clinical presentation and response to the administration of corticosteroids. Diagnostic testing may support the diagnosis, and the results of a recent multicenter study should clarify the role of immunologic testing in the diagnosis of this entity. Treatment options are limited, with corticosteroids being the only validated treatment option, and methotrexate offering no significant benefit to patients. The role of cyclophosphamide is restricted to patients willing to endure the attendant risks. With the advent of cochlear implants, the administration of toxic medications to preserve hearing at all costs is a less desirable option.

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Section: Differential Diagnosismentioning

confidence: 98%

Autoimmune inner ear disease

Ruckenstein

2004

Current Opinion in Otolaryngology & Head and Neck Surgery

133

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“…Some of them found that autoantibodies against human hsp70 are present in everyone in the healthy adult population [8][9] while most of the studies concluded that the occurrence of these antibodies is less frequent, or scarce, depending on the method of detection. [10][11][12][13] Humoral immunity against hsp70 was implicated in certain pathological conditions, like schizophrenia, [13] Menie`re disease [14][15] and some autoimmune diseases, like mixed connective tissue disease, rheumatoid arthritis, [16] Graves' disease, [11] autoimmune liver disease [17] and systemic lupus erythematosus (SLE), [16,[18][19][20] although the results regarding SLE and Menie`re disease are controversal.…”

Section: Introductionmentioning

confidence: 99%

ANTIBODIES AGAINST THE HUMAN HEAT SHOCK PROTEIN hsp70 IN PATIENTS WITH SEVERE CORONARY ARTERY DISEASE

Kocsis

Veres

Vatay

et al. 2002

Immunological Investigations

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Heat shock proteins (hsps) play complex role in the function of the immune system, they can activate both humoral and cellular immune response, as well the complement system. Although autoimmunity to hsp70 was implicated in certain autoimmune diseases and other conditions, the exact role of anti-hsp70 antibodies is not known. It was demonstrated by our previous work and other's findings that antibodies against the 60 kDa hsps are strongly associated with coronary atherosclerosis and carotis disease. It is also known that there is increased hsp70 expression at different sites of atherosclerosis. Therefore our aim was to study whether level of anti-hsp70 antibodies correlate with the presence of severe coronary artery disease (CAD). We measured and compared anti-hsp70 IgG antibody levels in CAD patients (n = 99) and healthy subjects (n = 99) with ELISA. The frequency of these antibodies was high in both groups and there was no significant difference in the median level of anti-hsp70 antibodies between patients with severe CAD and controls (653 (400-1141) vs. 630 (326-1152) AU/mL, P = 0.337). Adjustment for age, sex, BMI and lipid parameters did not change this result. Furthermore we did not find a correlation between anti-hsp70 antibody levels and certain risk factors of CAD (age, lipid parameters, body mass index, C-reactive protein, gender, smoking, diabetes and anti-hsp60 antibodies). By contrast, in accordance with our previous findings, anti-hsp60 and anti-hsp65 antibody levels were significantly higher in CAD patients, compared to this control group (p < 0.0001 for both variables). We did not find any correlation between the levels of anti-hsp70 and anti-hsp60 or anti-hsp65 antibodies either in the patients or the controls. The exact role of hsp70 in atherosclerosis is controversial, but we suggest that humoral immunity against human hsp70 does not contribute to coronary atherosclerosis in contrast to antibodies against 60kDa hsps.

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“…A vertigem é um dos mais complicados sintomas para o médico e para o paciente, pois este apresenta dificuldades para descrever seus sintomas 8 . Numa crise típica de Ménière encontramos: vertigens rotatórias, queda de audição (em geral unilateral), zumbidos, pressão aural, desconforto a sons intensos e sintomas neurovegetativos.…”

Section: Introductionunclassified

“…Após algumas crises, todas as freqüências são acometidas e a perda torna-se irreversível, podendo ser identificada na audiometria tonal limiar 8 . A ocorrência de crises com flutuação da audição caracteriza a doença de Ménière.…”

Section: Introductionunclassified

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Doença de Ménière em criança

Magalhães¹,

Pacheco²

2004

Rev. Bras. Otorrinolaringol.

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A Doença de Ménière foi descrita pela primeira vez por Prosper Ménière no século XIX e ainda nos dias atuais não existem explicações definitivas para a sua etiologia e para a sua fisiopatologia. A tétrade formada por esta doença é constituída de zumbido, vertigem, queda da acuidade auditiva e a sensação de plenitude aural. A faixa etária mais acometida pela doneça de Méniére corresponde à terceira e quinta dé-cadas de vida, sendo de ocorrência pouco comum em crianças. Este relato tem como objetivo demonstrar que a doença de Ménière, mesmo sendo de baixa ocorrência em crianças, pode vir a acometer esta população e o otorrinolaringologista deve estar apto para o diagnóstico e tratamento. Neste relato de caso, uma criança de 11 anos apresentou, após um episódio de edema facial de causa indeterminada associado a sintomas cócleo-vestibilares, um quadro de Doença de Ménière após uma investigação mais minuciosa. O tratamento com drogas depressoras do labirinto e vasodilatadoras promoveram uma melhora sensível, dando fim à sintomatologia.

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Anti–Heat Shock Protein 70 Antibodies in Meniere's Disease

Cited by 34 publications

References 49 publications

Autoimmune inner ear disease

Autoimmune inner ear disease

ANTIBODIES AGAINST THE HUMAN HEAT SHOCK PROTEIN hsp70 IN PATIENTS WITH SEVERE CORONARY ARTERY DISEASE

Doença de Ménière em criança

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