Anti-hepatitis B virus activities of triterpenoid saponin compound from Potentilla anserine L.

Zhao, Yu; Cai, G.-M.; Hong, Xi; Shan, Limei; Xiao, Xiang

doi:10.1016/j.phymed.2008.01.005

Cited by 79 publications

(50 citation statements)

References 21 publications

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“…Many studies have suggested that fibrotic development can be controlled or inhibited through clinically therapeutic regimes [21]. In addition, plant-isolated active components, such as phloridzin [22], triterpenoid saponin [23] and puerarin [24], exert an effective antifibrotic role. Our data showed that body weight loss and hepatomegalia occurred in CCl 4 -injured rats, indicating that the signs of malnourishment were due to CCl 4 -induced hepatotoxicity.…”

Section: Discussionmentioning

confidence: 99%

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Wei

Huang

Liu

et al. 2015

Cell Physiol Biochem

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Background/Aims: Our previous studies have shown that plumbagin effectively inhibits hepatic stellate cell (HSC) proliferation. Thus, plumbagin-mediated anti-fibrotic effects in vivo merit further investigation. Methods: We used rat models to assess the potential benefits of plumbagin against CCl₄-induced liver fibrosis. Results: The results showed that plumbagin lowered the serum concentrations of liver functional enzymes (ALT, AST, ALB, TBIL) in CCl₄-fibrotic rats while reducing inflammatory cytokine levels (IL-6, TNF-a). As reflected in pathological examinations, rats that were administered plumbagin showed decreased collagen markers (HA, LN, PCIII and CIV) in liver tissues and improved hepatocellular impairments. In addition, plumbagin contributed to down-regulating NF-κB and TLR-4 mRNA in CCl₄-lesioned livers. As revealed in the immunohistochemical assay, plumbagin-administered rats showed reduced levels of a-SMA and TNF-a immunoreactive cells in liver tissue. Conclusion: Collectively, these findings offer appealing evidence that plumbagin may serve as an anti-fibrotic medication through inactivating the NF-κB/TLR-4 pathway that is associated with inflammatory reactions, thereby mitigating liver fibrosis.

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Section: Discussionmentioning

confidence: 99%

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Wei

Huang

Liu

et al. 2015

Cell Physiol Biochem

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“…Potentilla erecta Stachurski et al (1995) Potentilla anserina Li et al (2003) Potentilla discolor Jang et al (2007) 19-Hydroxy-2,3-secours-12-ene-2,3,28-trioic acid 3-methyl ester Potentilla multicaulis Li et al (2007) 19-Hydroxy-1-oxo-2-nor-2,3-secours-12-ene-3,28-dioic acid (3␤,18␣,19␣)-3,28-Dihydroxy-20,28-epoxyursan-24-oic acid 3␤,19␣-Dihydroxyurs-12-en-28-oic acid ␤-d-glucopyranosyl ester Potentilla erecta Bilia et al (1994) 2␣,3␤-Dihydroxyurs-12-en-28-oic acid ␤-d-glucopyranosyl ester 3␤,19␣-Dihydroxyolean-12-en-28-oic acid ␤-d-glucopyranosyl ester 2␣,3␤,19␣-Trihydroxyurs-12-en-28-oic acid ␤-d-glucopyranosyl ester Potentilla anserina Zhao et al (2008) Wolf (1908) listed 302 species and divided them into two sections -Trichocarpae and Gymnocarpae -and many subsections, series and tribes or groups of species (Wolf, 1908;Guillén et al, 2005). The genus Potentilla is well known for its difficulties in identifying species and the frequent synonymies (Nicolè et al, 2007).…”

Section: Laevigatin Bmentioning

confidence: 99%

“…In Chinese traditional medicine Potentilla extracts have been used to treat diarrhoea, hepatitis, rheuma and scabies and as a remedy for detoxification (Xue et al, 2005(Xue et al, , 2006. In Tibetan traditional medicine Potentilla anserina root extracts have been applied for the treatment of certain viral infections (Zhao et al, 2008). Similarly the same or other (local) Potentilla species have been used in traditional medicine of different cultures in Asia, Europe and Northern America.…”

Section: Introductionmentioning

confidence: 99%

Potentilla—A review of its phytochemical and pharmacological profile

Tomczyk

Latté²

2009

Journal of Ethnopharmacology

244

213

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“…Triterpenoids are among the major functional compounds in some plants of the Schizandra genus . Several triterpenoids are considered "drug-like" natural compounds because they exhibit anti-inflammatory, anti-viral, anti-tumor, hepatoprotective, anti-bacterial, and antioxidant effects (Sultana and Ata, 2008;Asl and Hosseinzadeh, 2008;Ni et al, 2011;Zhao et al, 2008). Oleanolic acid, which is a triterpenoid constituent of SC, protected mice against carbon tetrachloride (CCl 4 )-induced hepatotoxicity and inhibited lipid peroxidation in rat liver microsomes (Jeong, 1999;Liu et al, 1995;Kim et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Hepatoprotective Effects of Triterpenoid Isolated from Schizandra chinensis against Acute Alcohol-Induced Liver Injury in Mice

Zhu

Liu

et al. 2013

FSTR

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Schizandra chinensis (Turcz.) Baill (SC) is useful for the regulation of various pathological conditions in Northeast Asia and is known to possess antioxidant activity. Here, triterpenoid of SC (TSC) was isolated from ethanol-water extracts of SC by using an octadecylsilyl column and shown to be one of the major active constituents of SC. The hepatoprotective effects of TSC in a mouse model of acute alcohol-induced liver injury (AALI) were evaluated based on serum biochemical indicators and antioxidative capacity. Severe liver damage caused by alcohol intake with increasing activation of hepatic markers was decreased in the group of mice fed TSC, and the results were confirmed through hematoxylin and eosin staining. Serum biochemical indicators and antioxidative capacity were decreased by alcohol but recovered by TSC. Furthermore, TSC increased the activity of antioxidant enzymes and reduced inflammatory reactions. The experimental results indicate that TSC has preventive and therapeutic effects against AALI.Keywords: Schizandra chinensis, triterpenoid, acute alcohol-induced liver injury, mice, octadecylsilyl *To whom correspondence should be addressed. E-mail: mengxjsy@126.com IntroductionExcessive alcohol consumption is the primary cause of liver disease in most countries, and to date, there is no satisfactory therapeutic drug (Fung et al., 2007). As a severe hepatotoxicant, alcohol causes alcoholic liver disease (ALD), which is associated with a spectrum of liver injury ranging from steatosis and steatohepatitis to fibrosis and cirrhosis (Tilg and Day, 2007;O'Shea et al., 2010;An et al., 2012). ALD is associated with increased production of proinflammatory cytokines/chemokines and imbalanced immune responses (Tilg and Diehl, 2000;McClain et al., 2004), and alcohol-induced oxidative stress is caused by 3 ethanol metabolic pathways that involve alcohol dehydrogenase, the microsomal ethanol oxidation system, and catalase (Das and Vasudevan, 2007). Alcohol is metabolized by alcohol dehydrogenase to form acetaldehyde, which is processed to generate free radicals . Peroxisomal activity also results in ethanol oxidation in the liver and may be more obvious in heavy ethanol consumers, who show accumulation of fatty acids in the liver because of increased fatty acid peroxisomal oxidation (Koch et al., 2004).Schizandra chinensis (Turcz.) Baill (SC, Wuweizi in China) is a member of the Magnoliaceae family that occurs in the Northeast Asia (Hancke et al., 1999). It has been regarded as a useful material in the treatment of various pathological conditions over the last several decades in China, Korea, and Japan. The fruits and stems of SC are listed officially as a food and herbal medicine in the Chinese Pharmacopeia, and they have thus been widely added to functional foods and used to treat a variety of diseases (Lee et al., 2009). SC is known to contain a variety of bioactive constituents, including triterpenoid, lignans, polysaccharides, and sterols (Peng et al., 2005). Triterpenoids are among the major functional comp...

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Anti-hepatitis B virus activities of triterpenoid saponin compound from Potentilla anserine L.

Cited by 79 publications

References 21 publications

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Anti-Fibrotic Effect of Plumbagin on CCl4-Lesioned Rats

Potentilla—A review of its phytochemical and pharmacological profile

Hepatoprotective Effects of Triterpenoid Isolated from Schizandra chinensis against Acute Alcohol-Induced Liver Injury in Mice

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