Anti-Hepatitis B Virus Activity of Esculetin from Microsorium fortunei In Vitro and In Vivo

Huang, Si-Xin; Mou, Jun-Fei; Luo, Qiong; Mo, Qing-Hu; Zhou, Xian‐Li; Huang, Xiao; Xu, Qing; Tan, Xiangduan; Chen, Xu; Liang, Cheng-Qin

doi:10.3390/molecules24193475

Cited by 24 publications

(19 citation statements)

References 29 publications

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“…Above all, three compounds (90-92, Figure 33) showed a noteworthy antiviral activity against HCV with EC50 values ranging from 5.1 to 8.4 μM and selective indices (SI = CC50/EC50, which is a measure for the therapeutic window of the compound in an assay system) higher than 20. Huang and co-workers focused their attention on the investigation of the potentiality expressed by esculetin (or 6,7-dihydroxycoumarin) against hepatitis B virus (HBV) [131]. The results suggested that esculetin efficiently inhibits HBV replication both in vitro and in vivo, which provides an opportunity for further development of the compound as antiviral agent.…”

Section: Antiviral Activitymentioning

confidence: 99%

“…Frequently, inflammatory mediators are the target of anti-inflammatory drugs [134][135][136][137]. Huang and co-workers focused their attention on the investigation of the potentiality expressed by esculetin (or 6,7-dihydroxycoumarin) against hepatitis B virus (HBV) [131]. The results suggested that esculetin efficiently inhibits HBV replication both in vitro and in vivo, which provides an opportunity for further development of the compound as antiviral agent.…”

Section: Anti-inflammatory Activitymentioning

confidence: 99%

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An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Annunziata

Pinna

Dallavalle

et al. 2020

IJMS

280

156

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Privileged structures have been widely used as an effective template for the research and discovery of high value chemicals. Coumarin is a simple scaffold widespread in Nature and it can be found in a considerable number of plants as well as in some fungi and bacteria. In the last years, these natural compounds have been gaining an increasing attention from the scientific community for their wide range of biological activities, mainly due to their ability to interact with diverse enzymes and receptors in living organisms. In addition, coumarin nucleus has proved to be easily synthetized and decorated, giving the possibility of designing new coumarin-based compounds and investigating their potential in the treatment of various diseases. The versatility of coumarin scaffold finds applications not only in medicinal chemistry but also in the agrochemical field as well as in the cosmetic and fragrances industry. This review is intended to be a critical overview on coumarins, comprehensive of natural sources, metabolites, biological evaluations and synthetic approaches.

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Section: Antiviral Activitymentioning

confidence: 99%

Section: Anti-inflammatory Activitymentioning

confidence: 99%

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Annunziata

Pinna

Dallavalle

et al. 2020

IJMS

280

156

View full text Add to dashboard Cite

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“…Esculetin ( 2 ) from Microsorium fortunei (Moore) Ching. could not only inhibit the expression of the HBV antigens and HBV-DNA but also inhibit the expression of hepatitis B virus X(HBx) protein in a dose-dependent manner [ 20 ]. Chen et al [ 21 ] isolated a series of phenylpropanins from the core material, bark and root of S. asper , all of which had significant anti-HBV activity.…”

Section: The Natural Products Of Anti-hbvmentioning

confidence: 99%

Natural Products: Review for Their Effects of Anti-HBV

Liu

2020

BioMed Research International

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Hepatitis B is a global infectious disease, seriously endangering human health. Currently, there are mainly interferons and nucleoside analogues treatment of hepatitis B in the clinic, which have certain therapeutic effects on hepatitis B, but their side effects and drug resistance are increasingly prominent. Therefore, it is urgently needed to discover and develop new anti-HBV drugs, especially natural products, which have novel, high efficiency, and low toxicity anti-HBV compounds with novel antiviral mechanisms. In this manuscript, the natural products (polysaccharides and 165 compounds) with the activity of antihepatitis B virus are discussed according to their chemical classes, including 14 phenylpropanoids, 8 flavonoids,12 xanthones, 13 anthroquinones, 47 terpenoids, 6 alkaloids, 15 enediynes, 11 aromatics, 18 phenylalanine dipeptides compounds, and 13 others. In addition, the anti-HBV mechanism and targets of natural product were also discussed. The aim of this review is to report new discoveries about anti-HBV natural products and to provide reference for researchers.

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“…Globally, around two billion people show evidence of infection with hepatitis, and about 250-360 million people are chronically infected and at risk for liver disease, according to statistics. Cirrhosis, liver failure, or hepatocellular carcinoma develop in 15-40% of people infected with HBV [1][2][3]. HBV is a DNA virus that encodes surface antigen (HBsAg), core antigen (HBcAg), and pre-core antigen (HBeAg), which are used as diagnostic markers of HBV infection [1,2].…”

Section: Introductionmentioning

confidence: 99%

“…Cirrhosis, liver failure, or hepatocellular carcinoma develop in 15-40% of people infected with HBV [1][2][3]. HBV is a DNA virus that encodes surface antigen (HBsAg), core antigen (HBcAg), and pre-core antigen (HBeAg), which are used as diagnostic markers of HBV infection [1,2].…”

Section: Introductionmentioning

confidence: 99%

Isolation and Characterization of Two Chalcone Derivatives with Anti-Hepatitis B Virus Activity from the Endemic Socotraen Dracaena cinnabari (Dragon’s Blood Tree)

et al. 2022

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Hepatitis B virus (HBV) infection is prevalent and continues to be a global health concern. In this study, we determined the anti-hepatitis B virus (HBV) potential of the Socotra-endemic medicinal plant Dracaena cinnabari and isolated and characterized the responsible constituents. A bioassay-guided fractionation using different chromatographic techniques of the methanolic extract of D. cinnabari led to the isolation of two chalcone derivatives. Using a variety of spectroscopic techniques, including 1H-, 13C-, and 2D-NMR, these derivatives were identified as 2,4’-dihydroxy-4-methoxydihydrochalcone (compound 1) and 2,4’-dihydroxy-4-methoxyhydrochalcone (compound 2). Both compounds were isolated for the first time from the red resin (dragon’s blood) of D. cinnabari. The compounds were first evaluated for cytotoxicity on HepG2.2.15 cells and 50% cytotoxicity concentration (CC50) values were determined. They were then evaluated for anti-HBV activity against HepG2.2.15 cells by assessing the suppression of HBsAg and HBeAg production in the culture supernatants and their half maximum inhibitory concentration (IC50) and therapeutic index (TI) values were determined. Compounds 1 and 2 indicated inhibition of HBsAg production in a dose- and time-dependent manner with IC50 values of 20.56 and 6.36 μg/mL, respectively.

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Anti-Hepatitis B Virus Activity of Esculetin from Microsorium fortunei In Vitro and In Vivo

Cited by 24 publications

References 29 publications

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

An Overview of Coumarin as a Versatile and Readily Accessible Scaffold with Broad-Ranging Biological Activities

Natural Products: Review for Their Effects of Anti-HBV

Isolation and Characterization of Two Chalcone Derivatives with Anti-Hepatitis B Virus Activity from the Endemic Socotraen Dracaena cinnabari (Dragon’s Blood Tree)

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