Anti-Hepatitis B Virus Effects of Wogonin Isolated from Scutellaria baicalensis

Huang, Renjie; Chen, Chien-Chih; Huang, Huey-Lan; Chang, Chung-Gwo; Chen, Chieh-Fu; Chang, Chung-Ming; Hsieh, Μing-Tsuen

doi:10.1055/s-2000-9775

Cited by 92 publications

(79 citation statements)

References 5 publications

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“…This herb has been used for thousands of years in Asia for inflammatory diseases and also for hepatitis. The anti-HBV activity of wogonin was already reported in 2000, demonstrating its ability to suppress hepatitis B surface antigen (HBsAg) secretion in cell culture [30] . Recently, the suppression of both HBsAg and hepatitis B e-antigen (HBeAg) secretion was shown with an IC50 of 4 µg/mL [31] .…”

Section: -Arylbenzofuran Derivativesmentioning

confidence: 99%

Natural products as promising drug candidates for the treatment of hepatitis B and C

Wohlfarth

Efferth

2008

Acta Pharmacol Sin

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Hepatitis B virus (HBV) or hepatitis C virus (HCV) infections are a major threat worldwide. Combination therapy of interferon-α and ribavirin is currently the treatment of choice for HCV-infected patients. However, this regimen is only effective in approximately 50% of patients and provokes severe side-effects. Numerous natural alternatives for treating HCV have been suggested. Deoxynojirimycin and its derivatives are iminosugars which exert anti-HCV activity by inhibiting α-glucosidases. A non-immunosuppressive derivate of cyclosporine A, NIM811, exerts anti-HCV activity by binding to cyclophilin. Other natural products with promising anti-HCV activity are 2-arylbenzofuran derivatives, Mellein, and pseudoguaianolides. For HBV treatment, several drugs are available, specifically targeting the virus polymerase (lamivudine, entecavir, telbivudine, and adefovir dipivoxil). The efficacy of these drugs is hampered by the development of resistance due to point mutations in the HBV polymerase. Due to drug resistance and adverse side-effects, the search for novel drugs is mandatory. Wogonin, ellagic acid, artemisinin and artesunate, chrysophanol 8-O-β-D-glucoside, saikosaponin C, and protostane triterpenes are active against HBV. Natural products need to be investigated in more detail to explore their potential as novel adjuncts to established HBV or HCV therapy.

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Section: -Arylbenzofuran Derivativesmentioning

confidence: 99%

Natural products as promising drug candidates for the treatment of hepatitis B and C

Wohlfarth

Efferth

2008

Acta Pharmacol Sin

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“…Wogonoside has been reported to possess free radical scavenging and antioxidant activities. 4) Baicalin, baicalein and wogonin have been extensively explored to show anti-inflammatory, 5,6) antiviral, [7][8][9] free radical scavenging, 4,10) antioxidant 10,11) and anticancer activities. [12][13][14] In addition, baicalin was also shown to induce apoptosis in prostate cancer cell line.…”

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confidence: 99%

Urinary Pharmacokinetics of Baicalein, Wogonin and Their Glycosides after Oral Administration of Scutellariae Radix in Humans.

Lai¹,

Hsiu²,

Chen³

et al. 2003

Biological & Pharmaceutical Bulletin

112

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Baicalin, baicalein, wogonoside and wogonin are flavone constituents of Scutellariae Radix with various beneficial biological activities. The purpose of this study was to investigate the urinary pharmacokinetics of these flavones after oral administration of Scutellariae Radix commercial powder. Ten healthy male volunteers received a dose of 5.2 g commercial powder (comparable to 9 g crude drug), respectively. The concentrations of baicalin, baicalein and wogonin in the commercial powder as well as their metabolites in urine were assayed by HPLC method. The glucuronides and sulfates of baicalein and wogonin in urine were hydrolyzed with b b-glucuronidase and sulfatase, respectively. Our results showed that the mean cumulated renal excretion of baicalein glucuronides and sulfates were 43.1؎4.5 m mmol (2.9% of dose) and 64.8؎6.3 m mmol (4.3% of dose), respectively, whereas wogonin glucuronides and sulfates were 21.6؎2.0 m mmol (5.9% of dose) and 20.7؎1.7 m mmol (5.7% of dose), respectively. The result indicated that the renal excretion of conjugated metabolites of wogonin (11.6% of dose) were higher than that of baicalein (7.2% of dose). The baicalein sulfates was predominant than the corresponding glucuronides, whereas wogonin sulfates was comparable to the corresponding glucuronides.

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“…In the hepatitis B virus (HBV)-producing cell line (M2-G2), wogonin suppressed HBV surface antigen production without cytotoxic effect (18). Similarly, using a cytopathic effect assay, Ma et al (35) demonstrated in vitro antiviral effect of wogonin using respiratory syncytial virus (RSV).…”

Section: Antiviral Effectsmentioning

confidence: 99%

Therapeutic Potential of Wogonin: A Naturally Occurring Flavonoid

et al. 2005

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The search for flavonoids with novel therapeutic effects has been intense. Wogonin, as a naturally existing monoflavonoid, has been shown to have therapeutic potential in vitro and in vivo. Methods for its extraction from herbs and its chemical synthesis have been developed. Pharmacokinetic studies have shown a rapid tissue distribution and prolonged plasma elimination phase of wogonin. It has been shown experimentally that wogonin exerts anti-oxidant activity, which may, in part, underlie its antiinflammatory, anti-cancer, antiviral and neuroprotective actions. The recent discovery of its anxiolytic activity suggests a new mechanism of action, involving interaction with the benzodiazepine (BZD) binding site of the GABA A receptor and modulation of this receptor activity. Although the safety record of wogonin is remarkable and voluminous literature about its pharmacological effects is available, it has not been used in Western medicine in the form of a pure chemical. In this article we review its therapeutic effects, its sources and pharmacokinetic profile to highlight its therapeutic potential.

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Anti-Hepatitis B Virus Effects of Wogonin Isolated from Scutellaria baicalensis

Cited by 92 publications

References 5 publications

Natural products as promising drug candidates for the treatment of hepatitis B and C

Natural products as promising drug candidates for the treatment of hepatitis B and C

Urinary Pharmacokinetics of Baicalein, Wogonin and Their Glycosides after Oral Administration of Scutellariae Radix in Humans.

Therapeutic Potential of Wogonin: A Naturally Occurring Flavonoid

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