Anti-Hepatitis C Virus Positivity and Clinical Correlations in Hemodialyzed Patients

Medici, Giuseppe; Depetri, Giorgio Carlo; Mileti, M

doi:10.1159/000186945

Cited by 9 publications

(6 citation statements)

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“…The risk of acquiring HCV infection on hemodialysis has been estimated at 10% per year [13] [14]; so that the time on hemodialysis is an independent risk factor for acquiring HCV infection [15]. Our data were concordant with literature data.…”

Section: Discussionsupporting

confidence: 89%

Higher Endogenous Erythropoietin Levels in Hemodialysis Patients with Hepatitis C Virus Infection and Effect on Anemia

Boubaker¹,

Mahfoudhi²,

Battikh³

et al. 2015

OJNeph

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Study for influence of chronic Hepatitis C (HCV) on endogenous erythropoietin production and on anemia in dialysis patients remains inconclusive. We hypothesize that chronic hemodialysis patients with co-existing Hepatitis C infection will have higher hemoglobin levels than chronic hemodialysis patients without hepatitis C infection. Secondly, we hypothesize that the higher hemoglobin levels will be associated with higher erythropoietin levels. Therefore we conducted a cross-sectional study of chronic hemodialysis patients with and without hepatitis C infection and evaluated associations with hemoglobin and erythropoietin levels. Our primary outcome was level of hemoglobin. Secondary outcome included association of hemoglobin and erythropoietin levels. 57 chronic hemodialysis patients (33 male, 24 female, mean age 46.05 ± 12.7 years) were included. The mean time spent on hemodialysis was 7.16 ± 6.2 years. None of the patients received any recombinant EPO therapy. Biochemical analyses include ALT, AST, Albumin, C-Reactive Protein, cholesterol levels and complete blood counts. Iron status of patients (transferrin saturation and serum ferritin levels) and parathyroid hormone were measured. Endogenous EPO serum levels were measured by a standardized enzyme-linked immunoassay. 23 of the hemodialysed patients (38.5%) were HCV (+). There was no difference in age, sex, distribution of primary renal diseases, iron status, albumin, C-Reactive-Protein and parathyroid hormone levels between HCV (+) and (−) patients. Mean duration time on dialysis was higher in HCV (+) than HCV (−) patients. Hemoglobin levels were similar between study groups. However serum endogenous erythropoietin levels were significantly higher in HCV (+) patients than HCV (−) patients (19.6 ± 10 mUI/ml vs 7.8 ± 7.7 mUI/ml, p = 0.03). No correlation has been found between the severity of anemia and HCV infection. However, HCV (+) hemodialysed patients had higher serum endogenous erythropoietin levels * Corresponding author. K. Boubaker et al. 30as compared to HCV (−) patients. Further studies are needed to clarify why high endogenous erythropoietin level does not improve anemia in HCV infected hemodialysis patients.

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Section: Discussionsupporting

confidence: 89%

Higher Endogenous Erythropoietin Levels in Hemodialysis Patients with Hepatitis C Virus Infection and Effect on Anemia

Boubaker¹,

Mahfoudhi²,

Battikh³

et al. 2015

OJNeph

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“…The prevalence of anti-HCV among dialysis patients is frequently considerably higher than in the general population in the background area (38,(64)(65)(66)(67)(68)(69)(70)(71). This observation and the wide variations in the prevalence of anti-HCV among different HD centers suggest that transmission of HCV does occur in dialysis centers and is most likely related to some aspects of the dialytic process.…”

Section: Evidence Supporting the Utility Of Routine Serologic Testingmentioning

confidence: 99%

Routine Serologic Testing for Hepatitis C Virus Infection Should Be Instituted Among Dialysis Patients

Natov

Pereira

2000

Seminars in Dialysis

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Since the cloning of hepatitis C virus (HCV), a number of serologic and virologic tests for detecting infections with this virus have been made available for clinical practice. This led to the recognition of HCV as a major health hazard in hemodialysis (HD) centers. Yet the nephrology community has not been offered explicit recommendations about routine serologic testing for HCV of dialysis patients and consequently has remained unclear and divided about the utility of this testing. This review presents evidence in support of instituting routine serologic testing for HCV among dialysis patients. It concludes that because of the peculiar features of HCV infection in HD patients, serologic testing for HCV is the only means for unequivocal diagnosis of hepatitis C and an irreplaceable instrument for monitoring the incidence and the prevalence of the infection in this population. Serologic surveillance for HCV infection is crucial for identifying the association of new cases of HCV infection with potential risk factors for HCV transmission, particularly nosocomial, that can be modified in a way to prevent further dissemination of the virus. Data collected from routine serologic testing for HCV will undoubtedly improve our understanding of the epidemiology of HCV in the dialysis population and will provide a strong foundation for developing preventive measures and infection control strategies that are highly effective in controlling HCV infection. Routine serologic testing for HCV is also of direct benefit to the individual patient since establishing the HCV serologic status of each patient is important for optimizing patient care.

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“…The risk of seroconversion was found to be higher in patients dialyzed next to an HCV-positive patient compared with other patients in the same unit [5]. The strong association between the duration of maintenance HD and HCV infection [9,10,25] and the higher prevalence of anti-HCV among HD patients is suggestive of cross-infection through the HD environment and nosocomial acquisition of the virus. Such infection is expected from viral contamination of dialysis instruments, gloves or drug preparations [25].…”

Section: Discussionmentioning

confidence: 99%

“…Other risk factors for HCV infection include intravenous drug addiction, organ transplantation, and sexual and vertical transmission [7,8]. The prevalence of HCV antibodies increases significantly with the duration on HD [9,10]. Patients dialyzed with the same machine as HCV-positive patients or located next to them during dialysis are likely to be at a higher risk of infection with HCV [5].…”

Section: Introductionmentioning

confidence: 99%

Hand Contamination with Hepatitis C Virus in Staff Looking after Hepatitis C-Positive Hemodialysis Patients

Alfurayh¹,

Sabeel²,

Ahdal

et al. 2000

Am J Nephrol

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Background: Hepatitis C virus (HCV) is a major cause of hepatitis in hemodialysis (HD) patients. Routes other than blood transfusion play a role in the spread of HCV in HD patients. Molecular studies of HCV implicate nosocomial transmission of the virus in HD units. We conducted a clinicovirological study in our HD unit to investigate if the hands of dialysis personnel could represent a mode of transmission of HCV among HD patients. Methods: One liter of sterile water was used for each handwashing of dialysis personnel. The washing was collected in a sterile container and tested for HCV-RNA by polymerase chain reaction (PCR) within 3 h of collection. Eighty handwashings from nurses dialyzing HCV-positive patients (groupe A) and 100 handwashing from nurses dialyzing HCV-negative patients (group B) were tested for HCV-RNA. As a control, 60 handwashings were collected from the dialysis personnel before entering the dialysis unit (group C) and tested for HCV-RNA. Results: HCV-RNA was positive in 19 (23.75%) of samples of group A, in 8 (8%) of samples of group B (p < 0.003) and in 2 (3.3%) of samples of group C (p < 0.35). These two positive samples of group C were from nurses who had dialyzed HCV-negative patients. Conclusion: These results indicate the presence of HCV-RNA on the hands of some dialysis personnel in our HD unit, in spite fo adherence to the standard precautions. The hands of dialysis personnel are therefore a potential mode for facilitating transmission of HCV between HD patients.

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Anti-Hepatitis C Virus Positivity and Clinical Correlations in Hemodialyzed Patients

Abstract: The present study refers to the evaluation of the prevalence of anti-HCV positivity and its correlation with biochemical markers of chronic liver disease (negative), dialytic age (positive) and blood transfusions (negative) in 56 hemodialized patients.

Cited by 9 publications

References 0 publications

Higher Endogenous Erythropoietin Levels in Hemodialysis Patients with Hepatitis C Virus Infection and Effect on Anemia

Higher Endogenous Erythropoietin Levels in Hemodialysis Patients with Hepatitis C Virus Infection and Effect on Anemia

Routine Serologic Testing for Hepatitis C Virus Infection Should Be Instituted Among Dialysis Patients

Hand Contamination with Hepatitis C Virus in Staff Looking after Hepatitis C-Positive Hemodialysis Patients

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