Anti-herpes virus activity of the carnivorous botanical, Sarracenia purpurea

Kannan, Latha; Kumar, Ashok; Kumar, Aradhana; Jacobs, Bertram L.; Langland, Jeffrey

doi:10.1038/s41598-020-76151-w

Cited by 9 publications

(7 citation statements)

References 54 publications

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“…Within this time frame, there were two (1.46%) studies in 2015 [ 6 , 7 ], 15 (10.95%) studies in 2016 [ 1 , 3 , 8 - 20 ], 19 (13.87%) studies in 2017 [ 21 - 39 ], 27 (19.71%) studies in 2018 [ 40 - 64 ], 23 (16.79%) studies in 2019 [ 2 , 65 - 86 ], 24 (17.52%) studies in 2020 [ 87 - 110 ], and 27 (19.70%) studies in 2021 [ 111 - 137 ]. Regarding the type of studies reviewed, 121 (88.32%) studies included in vitro elements [ 2 , 3 , 6 - 12 , 14 - 20 , 23 - 26 , 28 - 42 , 44 - 47 , 49 - 56 , 58 - 64 , 66 , 68 - 72 , 74 - 77 , 79 , 80 , 82 - 87 , 89 - 118 , 120 , 122 - 133 , 135 - 139 ] and 23 (16.79%) in vivo [ 2 , 13 , 15 , 18 , 22 , 25 , 27 , 28 , 37 , 43 , 48 , 56 , 62 , 67 , 73 , 78 , 81 , 100 , …”

Section: Reviewmentioning

confidence: 99%

“…Sample size was extremely variable and unable to be compared due to the differences in study designs. In terms of sample characteristics, 99 (72.26%) studies used Vero cells [ 2 , 3 , 6 , 8 - 10 , 14 - 20 , 23 , 25 , 26 , 28 , 30 - 34 , 36 , 39 - 42 , 44 - 47 , 50 , 51 , 53 - 56 , 58 - 64 , 66 - 70 , 72 , 74 , 76 , 77 , 79 , 82 , 83 , 85 - 87 , 89 - 95 , 97 - 108 , 111 - 113 , 115 - 118 , 120 , 122 , 123 , 125 - 130 , 132 , 133 , 135 , 137 , 138 ], 41 (29.93%) used human cell lines [ 7 , 11 , 12 , 16 , 19 , 24 , 29 , 31 , 36 , 38 , 47 , 49 , 52 - 56 , 61 , 62 , 67 ,…”

Section: Reviewmentioning

confidence: 99%

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A Systematic Review of Second-Line Treatments in Antiviral Resistant Strains of HSV-1, HSV-2, and VZV

Lince¹,

DeMario²,

Yang³

et al. 2023

Cureus

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Drug-resistant variants of herpes simplex viruses (HSV) have been reported that are not effectively treated with first-line antiviral agents. The objective of this study was to evaluate available literature on the possible efficacy of second-line treatments in HSV and the use of second-line treatments in HSV strains that are resistant to first-line treatments. Following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, a final search was conducted in six databases on November 5, 2021 for all relevant literature using terms related to antiviral resistance, herpes, and HSV. Eligible manuscripts were required to report the presence of an existing or proposed second-line treatment for HSV-1, HSV-2, or varicella zoster virus (VZV); have full-text English-language access; and potentially reduce the rate of antiviral resistance. Following screening, 137 articles were included in qualitative synthesis. Of the included studies, articles that examined the relationship between viral resistance to first-line treatments and potential second-line treatments in HSV were included. The Cochrane risk-of-bias tool for randomized trials was used to assess risk of bias. Due to the heterogeneity of study designs, a meta-analysis of the studies was not performed. The dates in which accepted studies were published spanned from 2015-2021. In terms of sample characteristics, the majority (72.26%) of studies used Vero cells. When looking at the viruses on which the interventions were tested, the majority (84.67%) used HSV-1, with (34.31%) of these studies reporting testing on resistant HSV strains. Regarding the effectiveness of the proposed interventions, 91.97% were effective as potential managements for resistant strains of HSV. Of the papers reviewed, nectin in 2.19% of the reviews had efficacy as a second-line treatments in HSV, amenamevir in 2.19%, methanol extract in 2.19%, monoclonal antibodies in 1.46%, arbidol in 1.46%, siRNA swarms in 1.46%, Cucumis melo sulfated pectin in 1.46%, and components from Olea europeae in 1.46%. In addition to this griffithsin in 1.46% was effective, Morus alba L. in 1.46%, using nucleosides in 1.46%, botryosphaeran in 1.46%, monoterpenes in 1.46%, almond skin extracts in 1.46%, bortezomib in 1.46%, flavonoid compounds in 1.46%, andessential oils were effective in 1.46%, but not effective in 0.73%. The available literature reviewed consistently supports the existence and potentiality of second-line treatments for HSV strains that are resistant to first-line treatments. Immunocompromised patients have been noted to be the population most often affected by drug-resistant variants of HSV. Subsequently, we found that HSV infections in this patient population are challenging to manage clinically effectively. The goal of this systematic review is to provide additional information to patients on the potentiality of second-line treatment in HSV strains resistant to first-line treatments, especially those who are immunocompromised. All patients,...

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Section: Reviewmentioning

confidence: 99%

Section: Reviewmentioning

confidence: 99%

A Systematic Review of Second-Line Treatments in Antiviral Resistant Strains of HSV-1, HSV-2, and VZV

Lince¹,

DeMario²,

Yang³

et al. 2023

Cureus

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“…Kannan et al (2020) demonstrated that S. purpurea extracts are able to hinder the replication of HSV-1 by two mechanisms of action, which are through (1) inhibiting extracellular virions or viral attachment to the human host cell and (2) inhibiting the expression of viral immediate–early, early, and late genes when added at various times post-infection. This botanical has also previously been shown to inhibit the replication of poxviruses via the early inhibition of viral gene transcription [ 110 ].…”

Section: Medicinal Plant For Treating Dermatology-related Virusesmentioning

confidence: 99%

A Review with Updated Perspectives on the Antiviral Potentials of Traditional Medicinal Plants and Their Prospects in Antiviral Therapy

Saifulazmi

Rohani²,

Harun³

et al. 2022

Life

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Exploration of the traditional medicinal plants is essential for drug discovery and development for various pharmacological targets. Various phytochemicals derived from medicinal plants were extensively studied for antiviral activity. This review aims to highlight the role of medicinal plants against viral infections that remains to be the leading cause of human death globally. Antiviral properties of phytoconstituents isolated from 45 plants were discussed for five different types of viral infections. The ability of the plants’ active compounds with antiviral effects was highlighted as well as their mechanism of action, pharmacological studies, and toxicological data on a variety of cell lines. The experimental values, such as IC50, EC50, CC50, ED50, TD50, MIC100, and SI of the active compounds, were compiled and discussed to determine their potential. Among the plants mentioned, 11 plants showed the most promising medicinal plants against viral infections. Sambucus nigra and Clinacanthus nutans manifested antiviral activity against three different types of viral infections. Echinacea purpurea, Echinacea augustofolia, Echinacea pallida, Plantago major, Glycyrrhiza uralensis, Phyllanthus emblica, Camellia sinensis, and Cistus incanus exhibited antiviral activity against two different types of viral infections. Interestingly, Nicotiana benthamiana showed antiviral effects against mosquito-borne infections. The importance of phenolic acids, alkamides, alkylamides, glycyrrhizin, epicatechin gallate (ECG), epigallocatechin gallate (EGCG), epigallocatechin (EGC), protein-based plant-produced ZIKV Envelope (PzE), and anti-CHIKV monoclonal antibody was also reviewed. An exploratory approach to the published literature was conducted using a variety of books and online databases, including Scopus, Google Scholar, ScienceDirect, Web of Science, and PubMed Central, with the goal of obtaining, compiling, and reconstructing information on a variety of fundamental aspects, especially regarding medicinal plants. This evaluation gathered important information from all available library databases and Internet searches from 1992 to 2022.

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“…S. purpurea L. is well known as Cree medicinal plant (Cieniak et al, 2015). The plants from Sarracenia genus were found to possess antioxidant, antidiabetic, antiviral and antibacterial constituents (Kannan et al, 2020;Muhammad et al, 2013, Cieniak et al, 2015, among them sarracenin (Hu et al, 2009), betulinic acid, ursolic acid (Cieniak et al, 2015), hyperoside (quercetin-3-O-galactoside), morroniside (Harris et al, 2012) and many others were detected and con rmed (Table 1). Because hairy roots cultures are promising method for the production of interesting secondary metabolites in plants (Tian, 2015) and these cultures can be applied for enhanced synthesis of bioactive compounds, the aim of this study was to establish the tissue culture of Sarracenia purpurea L. plants and transformation of them via agroinfection method with Agrobacterium rhizogenes strain.…”

Section: Introductionmentioning

confidence: 96%

Characterization of Carnivorous Plants Sarracenia Purpurea L. Transformed with Agrobacterium Rhizogenes

Pilarska

Panić

Redovniković

et al. 2021

Preprint

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Carnivorous plant of Sarracenia genus are used by human in folk medicine for centuries. The reason for this phenomenon is biochemical composition of Sarracenia plants, which possess many bioactive compounds with anti-inflammatory, antioxidant, antiviral and antibacterial properties.The subject of this research was genetic transformation of Sarracenia purpurea L. with Agrobacterium rhizogenes strain 15834, 9402 and A4 by using two alternatively methods of bacterial injection or co-culture the bacteria with plants explants. These studies confirmed the possibility of hairy roots induction in S. purpurea using the strain of A. rhizogenes 15834 and the injection method. Seven lines of transformed plants, exhibiting the integration of rolB gene, were obtained. The formed hairy roots showed morphological differences in comparison to the roots of unmodified plants. A mathematical model was used to optimize the conditions for the extraction of bioactive compounds. Extracts isolated under optimal conditions from transformed plants showed biochemical changes i.e., the increase in the accumulation of total polyphenols and triterpenes in comparison to untransformed plants, especially when induced roots were analyzed. HPLC analysis showed increase in the level of betulinic acid in some transformed Sarracenia lines. Betulinic acid remains pentacyclic triterpenoid compound with high pharmacological significance. The further work connected with isolation and identification of the other bioactive compounds will be done in the nearest future.

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Anti-herpes virus activity of the carnivorous botanical, Sarracenia purpurea

Cited by 9 publications

References 54 publications

A Systematic Review of Second-Line Treatments in Antiviral Resistant Strains of HSV-1, HSV-2, and VZV

A Systematic Review of Second-Line Treatments in Antiviral Resistant Strains of HSV-1, HSV-2, and VZV

A Review with Updated Perspectives on the Antiviral Potentials of Traditional Medicinal Plants and Their Prospects in Antiviral Therapy

Characterization of Carnivorous Plants Sarracenia Purpurea L. Transformed with Agrobacterium Rhizogenes

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