Anti-HIV-1 activity of phloroglucinol derivative, 6,6′-bieckol, from Ecklonia cava

Anti-HIV-1 activity of phlorotannin derivative 8,4‴-dieckol from Korean brown alga Ecklonia cava

“…30) Furthermore, Ahn et al 31) claimed that phloroglucinol derivative 8,8'-bieckol inhibited the activity of recombinant RT and protease of HIV-1 in vitro. Artan et al 32) reported the enhanced HIV-1 inhibitory effect of a phloroglucinol derivative, 6,6′-bieckol, from E. cava.…”

Extraction and Characterization of Bioactive Compounds with Health Benefits from Marine Resources: Macro and Micro Algae, Cyanobacteria, and Invertebrates

“…Nevertheless, the main activity related to phenolic compounds is antioxidant activity ). In addition to their strong antioxidant activities, phlorotannins are known to possess other activities ) including antibacterial (Nagayama et al 2002 ) , chemopreventive (Kang et al 2003 ) , UV-protective (Artan et al 2008 ) , and antiproliferative effects (Kong et al 2009 ) . They are also known to act as detoxifying agents against heavy metals (Eide et al 1980 ) , and have myriad other bioactivities that could potentially be exploited for use in functional foods Jung et al 2006 ;Yoon et al 2009 ) For example, the total antioxidant capacity of a Polysiphoma urceolata red algal extract is directly related to the total phenolic content (Duan et al 2006 ) .…”

Isolation of 6,6'-Bieckol from Grateloupia elliptica and its Antioxidative and Anti-Cholinesterase Activity

“…The isolated compound is 6,6'-bieckol, two eckols are connected by 6-6' covalent carbon-carbon bond. 6,6'-Bieckol is an eckoltype phlorotannin found in the brown algae Ecklonia cava (Artan et al 2008) and Ecklonia stolonifera (Lee et al 2012). It was isolated by solvent fractionations and a series of column chromatographies.…”