Anti-HIV Tigliane-Type Diterpenoids from the Aerial Parts of <i>Wikstroemia lichiangensis</i>

Zhou, Di; Otsuki, Kouharu; Zhang, Mi; Chen, Gang; Bai, Zisong; Yu, Hui; Kikuchi, Takashi; Huang, Li; Chen, Chin-Ho; Li, Wei; Li, Ning

doi:10.1021/acs.jnatprod.1c01195

Cited by 8 publications

(1 citation statement)

References 14 publications

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“…Recent studies suggest that 12-benzoyloxyphorbol may be more effective than 12-deoxyphorbol in displaying anti-HIV activity [42]. However, current r studies on 12-benzoyloxyphorbols have been limited to in vitro HIV replication inhibition and HIV LTR-driven transcription activity, and further investigation into their latent HIV activation activity is needed [33,42,[99][100][101].…”

Section: Anti-hiv Activitymentioning

confidence: 99%

Tigliane and daphnane diterpenoids from Thymelaeaceae family: chemistry, biological activity, and potential in drug discovery

Otsuki

2023

J Nat Med

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Tigliane and daphnane diterpenoids are characteristically distributed in plants of the Thymelaeaceae family as well as the Euphorbiaceae family and are structurally diverse due to the presence of polyoxygenated functionalities in the polycyclic skeleton. These diterpenoids are known as toxic components, while they have been shown to exhibit a wide variety of biological activities, such as anti-cancer, anti-HIV, and analgesic activity, and are attracting attention in the field of natural product drug discovery. This review focuses on naturally occurring tigliane and daphnane diterpenoids from plants of the Thymelaeaceae family and provides an overview of their chemical structure, distribution, isolation, structure determination, chemical synthesis, and biological activities, with a prime focus on the recent findings.

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