Anti-HSV activity of digitoxin and its possible mechanisms

Su, Chun Ting; Hsu, John; Hsieh, Hsing Pang; Lin, Pi Han; Chen, Ting Chi; Kao, Chuan-Liang; Lee, Chun Nan; Chang, Sui‐Yuan

doi:10.1016/j.antiviral.2008.01.156

Cited by 78 publications

(66 citation statements)

References 48 publications

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“…Digitoxin impaired the HSV viral life cycle at two different steps: viral DNA synthesis and viral release form the host cells. The authors also showed that others cardiac glycosides such as digoxin, ouabain, and G-strophanthin have comparable anti-HSV activity [19]. Finally, adenoviruses, which are common human pathogens, are also susceptible to cardiac glycosides such as digitoxin and digoxin, which are able to impair adenovirus genome replication by altering the host pre-RNA splicing machinery [39].…”

Section: Dna Viruses Affected By Nak-atpase Modulationmentioning

confidence: 99%

The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview

Amarelle

Lecuona

2018

IJMS

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Since being first described more than 60 years ago, Na,K-ATPase has been extensively studied, while novel concepts about its structure, physiology, and biological roles continue to be elucidated. Cardiac glycosides not only inhibit the pump function of Na,K-ATPase but also activate intracellular signal transduction pathways, which are important in many biological processes. Recently, antiviral effects have been described as a novel feature of Na,K-ATPase inhibition with the use of cardiac glycosides. Cardiac glycosides have been reported to be effective against both DNA viruses such as cytomegalovirus and herpes simplex and RNA viruses such as influenza, chikungunya, coronavirus, and respiratory syncytial virus, among others. Consequently, cardiac glycosides have emerged as potential broad-spectrum antiviral drugs, with the great advantage of targeting cell host proteins, which help to minimize resistance to antiviral treatments, making them a very promising strategy against human viral infections. Here, we review the effect of cardiac glycosides on viral biology and the mechanisms by which these drugs impair the replication of this array of different viruses.

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Section: Dna Viruses Affected By Nak-atpase Modulationmentioning

confidence: 99%

The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview

Amarelle

Lecuona

2018

IJMS

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“…The cytotoxicity assay of the samples was determined according to the method of Su et al (2008) by MTT assay. In brief, cells were plated at 2 × 10 4 cells per well in 96 well microtiter plates (Costar 3599, Corning, NY, USA) with 100 μL RPMI-1640 growth medium and incubated for 24 h at 37°C, with 5% CO 2 in a humidified atmosphere (Incu-Safe, Sanyo, Japan), during which period a partial monolayer was formed.…”

Section: Cytotoxicity Assaymentioning

confidence: 99%

Antioxidant and anticancer activities of high pressure-assisted extract of longan (Dimocarpus longan Lour.) fruit pericarp

Prasad

Hao

Shi

et al. 2009

Innovative Food Science & Emerging Technologies

104

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“…Acyclovir continues to be the reference drug for HSV diseases treatment even after three decades of its development [6]. However, in long-term treatment and especially in immunocompromised individuals, acyclovir can lead to the selection of resistant mutants [7]. These features highlight the need to develop new antiherpetic drugs.…”

Section: Introductionmentioning

confidence: 99%

Antiherpetic activity of an Agaricus brasiliensis polysaccharide, its sulfated derivative and fractions

Yamamoto

Faccin-Galhardi

Rincão

et al. 2013

International Journal of Biological Macromolecules

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Agaricus brasiliensis is an edible mushroom, traditionally used for the treatment of several diseases. In this paper, a polysaccharide (PLS) from A. brasiliensis, its carboxymethylated (CPLS) and sulfated (SPLS) derivatives, as well as, fractions (F1-F3) obtained from the PLS were investigated for their effect in the replication of herpes simplex virus and bovine herpes virus in HEp-2 cell cultures. The PLS, SPLS and F3 inhibited both virus strains similarly, in a dose-dependent curve. F1, F2 and CPLS did not show significant effect even at higher concentrations. All the compounds showed neither virucidal or viral adsorption inhibition activities nor effect when cells were treated prior to infection. Our study demonstrated that the extracts of A. brasiliensis, can be promising for future antiviral drug design and its biotechnological production is economically feasible.

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Anti-HSV activity of digitoxin and its possible mechanisms

Cited by 78 publications

References 48 publications

The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview

The Antiviral Effects of Na,K-ATPase Inhibition: A Minireview

Antioxidant and anticancer activities of high pressure-assisted extract of longan (Dimocarpus longan Lour.) fruit pericarp

Antiherpetic activity of an Agaricus brasiliensis polysaccharide, its sulfated derivative and fractions

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