Anti–Hu-Mediated Paraneoplastic Chronic Intestinal Pseudo-Obstruction Arising From Small Cell Prostate Cancer

Cerra-Franco, Javier A.; Fernandez-Cruz, Carlos; Estremera-Marcial, Rodolfo; Pagán-Torres, Hendrick; Martinez-Souss, Jaime; Toro, Doris H.

doi:10.14309/crj.0000000000000105

Cited by 5 publications

(9 citation statements)

References 13 publications

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“…Evans Syndrome [ 27 ], Limbic encephalitis [ 26 ], Hypercalcemia [ 19 ], CIPO [ 8 ], SIADH [ 24 , 25 ], dermatomyositis, and polycythemia [ 9 ] were the other seven PNS identified in our review. As with CS, the histological subtype in all of these syndromes was small-cell neuroendocrine cancer, except for dermatomyositis and polycythemia where it was large-cell carcinoma [ 8 , 9 , 25 , 26 , 27 ]. A previous history of prostate adenocarcinoma treated with ADT was identified in three out of the six cases, these patients passed away at a maximum of five months from their presentation.…”

Section: Resultsmentioning

confidence: 99%

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Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review

Abufaraj,

Ramadan,

Alkhatib

2024

Current Oncology

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Neuroendocrine prostate cancer (NEPC) is a rare subtype of prostate cancer (PCa) that usually results in poor clinical outcomes and may be accompanied by paraneoplastic syndromes (PNS). NEPC is becoming more frequent. It can initially manifest as PNS, complicating diagnosis. Therefore, we reviewed the literature on the different PNS associated with NEPC. We systematically reviewed English-language articles from January 2017 to September 2023, identifying 17 studies meeting PRISMA guidelines for NEPC and associated PNS. A total of 17 articles were included in the review. Among these, Cushing’s Syndrome (CS) due to ectopic Adrenocorticotropic hormone (ACTH) secretion was the most commonly reported PNS. Other PNS included syndrome of inappropriate Anti-Diuretic Hormone secretion (SIADH), Anti-Hu-mediated chronic intestinal pseudo-obstruction (CIPO), limbic encephalitis, Evans Syndrome, hypercalcemia, dermatomyositis, and polycythemia. Many patients had a history of prostate adenocarcinoma treated with androgen deprivation therapy (ADT) before neuroendocrine features developed. The mean age was 65.5 years, with a maximum survival of 9 months post-diagnosis. NEPC is becoming an increasingly more common subtype of PCa that can result in various PNS. This makes the diagnosis and treatment of NEPC challenging. Further research is crucial to understanding these syndromes and developing standardized, targeted treatments to improve patient survival.

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Section: Resultsmentioning

confidence: 99%

“…PCa is the second most common urological tumor associated with PNS, after renal cell carcinoma [ 7 ]. NEPC can cause a variety of paraneoplastic manifestations, including endocrine PNS such as CS and SIADH, in addition to dermatomyositis, polycythemia, and CIPO [ 7 , 8 , 9 ].…”

Section: Introductionmentioning

confidence: 99%

Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review

Abufaraj,

Ramadan,

Alkhatib

2024

Current Oncology

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“…Various paraneoplastic syndromes that have been reported to be associated with prostate cancer are SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome [ 4 ], hyperfibrinolysis [ 5 ], giant cell arteritis [ 6 ], Cushing syndrome [ 7 ], Stauffer syndrome [ 8 ], anti-Hu mediated intestinal pseudo-obstruction [ 9 ], and SIADH (syndrome of inappropriate antidiuretic hormone secretion) [ 10 ].…”

Section: Discussionmentioning

confidence: 99%

Paraneoplastic Evans Syndrome in a Patient With Prostate Cancer With Small Cell Transformation

Sidda¹,

Manu²,

Abdallah³

et al. 2022

Cureus

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Paraneoplastic syndromes are defined as tumor‐associated indirect systemic effects. Prostate cancer-associated paraneoplastic syndromes typically have endocrine, neurologic, and dermatologic manifestations. Reports have suggested up to 70% of metastatic prostate cancers manifest as paraneoplastic entities. Although common in hematological malignancies, it is rare for prostate cancer and other solid tumors to be associated with immune-mediated cytopenias such as Evans syndrome. Based on our PubMed search for the keywords Evans syndrome and prostate cancer, only one other case has been reported in the literature with this association. We report the second such case in a 63-year-old male who initially presented with hemolytic anemia and thrombocytopenia. He was diagnosed with Evans syndrome with initial responses to both steroids and intravenous immunoglobulin. Extensive workup, including an eventual bone marrow biopsy, revealed metastatic prostate cancer with transformation to small cell neuroendocrine carcinoma.

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“…There are several etiologies described in the literature as the possible culprits causing CIPO via the mechanisms mentioned above. These include neurological disordered (e.g., Parkinson disease and Shy-Drager syndrome), metabolic disorders (e.g., diabetes mellitus), paraneoplastic (e.g., small cell lung cancers, carcinoid tumors [ 3 ], malignant thymoma [ 4 ], and prostate cancer [ 5 ]), immune medicated (scleroderma, dermatomyositis, and systemic lupus erythematosus [ 6 ]), infectious (e.g., Chagas disease, viruses [ 7 ]), and in association with radiotherapy and chemotherapy for cancers.…”

Section: Discussionmentioning

confidence: 99%

Chronic Intestinal Pseudo-Obstruction in a Young Male With Alcohol Abuse Disorder

Haider

Mehershanhi

Siddiqa

et al. 2021

Cureus

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Chronic intestinal pseudo-obstruction (CIPO) is a rare syndrome associated with significant mortality and morbidity. It mimics the signs and symptoms of intestinal obstruction in the absence of an anatomic lesion causing obstruction. Here we present a case of a young male with severe alcohol abuse disorder who initially presented with signs and symptoms of alcohol withdrawal but was found to have abdominal distension. Imaging studies revealed severe small and large bowel dilatation without any organic lesion. He continued to have marked intestinal dilatation for the subsequent few months. Alcohol cessation eventually led to a marked reduction in his symptoms and a decrease in intestinal dilatation. The occurrence of CIPO because of alcohol abuse is rare, and we explore the possible association between the two entities.

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Anti–Hu-Mediated Paraneoplastic Chronic Intestinal Pseudo-Obstruction Arising From Small Cell Prostate Cancer

Cited by 5 publications

References 13 publications

Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review

Paraneoplastic Syndromes in Neuroendocrine Prostate Cancer: A Systematic Review

Paraneoplastic Evans Syndrome in a Patient With Prostate Cancer With Small Cell Transformation

Chronic Intestinal Pseudo-Obstruction in a Young Male With Alcohol Abuse Disorder

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