Anti-hyperalgesic and anti-allodynic activities of capillarisin via suppression of inflammatory signaling in animal model

Capillarisin attenuates exercise-induced muscle damage through MAPK and NF-κB signaling

“…The current study investigated the protective effect of capillarisin (CAP) against the production of ROS in the exercise-induced skeletal muscle and subsequent damage in mice for the first time. Previous studies showed that CAP had anti-inflammatory (Han et al, 2013;Khan et al, 2013), antihyperalgesic (Khan et al, 2014), and anti-cancer (Lee et al, 2014) activities, but no other studies have demonstrated its effects on skeletal muscle damage. The goal of this study was to investigate the CAP's effect on two main redox sensitive pathways, MAPKs signaling and NF-кB pathway, and suppression of exercise-induced ROS and muscle damage markers.…”

“…has been traditionally used as diuretics and anti-inflammatory agents (Khan et al, 2013). Recent studies have reported that capillarisin (CAP) has antihyperalgesic (Khan et al, 2014) and antitumor activity (Lee et al, 2014) …”

Capillarisin blocks prostate‐specific antigen expression on activation of androgen receptor in prostate carcinoma cells

“…11 Capillarisin (Cap) is an active component extracted from Artemisia capillaris, in which its young shoots being consumed as vegetables and the whole plant used as an herbal remedy for various inflammatory diseases, such as hepatitis, jaundice cholestasis, and urinary tract infections in Asia. 12 Cap has been reported with anti-inflammatory properties through mediating NFκ-B and MAPKs signaling pathways in vitro and in vivo, [13][14][15][16] and with antioxidant characteristics in primary hepatocytes. 17,18 Studies also indicated that Cap suppressed cancer cell proliferation, survival, and invasion in estrogen-positive breast carcinoma MCF-7 cells, 19 B-lymphoblast cells, 20 and osteosarcoma cells.…”

The inhibitory effects of capillarisin on cell proliferation and invasion of prostate carcinoma cells

“…Komiya et al first recognized the molecular structure of Capillarisin (Cap), an active element extracted from AC, as 2‐( p ‐hdroxyphenoxy)‐6‐methoxy‐5,7‐dihydroxychromoneas (C 16 H 12 O 7 ) with strong choleretic activity. Previous studies indicated that Cap has anti‐inflammation, anti‐oxidation and anti‐cancer biological activities . Cap induces apoptosis and cell cycle arrest in osteosarcoma cancer cells .…”

“…Previous studies indicated that Cap has anti-inflammation, anti-oxidation and anti-cancer biological activities. [11][12][13] Cap induces apoptosis and cell cycle arrest in osteosarcoma cancer cells. 14 Furthermore, it has been reported to suppress cancer cell invasion via inhibition of NFκBdependent matrix metallopeptidase (MMP)9 expression in MCF-7 cells and inhibition of the STAT3 signalling cascade in multiple myeloma cell lines.…”