Anti-hyperglycemic and anti-dyslipidemic activities of methanol ripe fruit extract of Duranta erecta L (Verbenaceae) in normoglycemic and hyperglycemic rats

Eke, Ifeanyi G.; Okpara, G. C.

doi:10.1016/j.jtcme.2020.03.007

Cited by 6 publications

(3 citation statements)

References 26 publications

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“…The medicinal properties of Duranta erecta have been proven for different ailments, including cancer, based on in vitro, in vivo, and in silico experiments [25][26][27][28][29][30] . The plant has not been investigated extensively in breast cancer and the molecular mechanism of action is unknown.…”

Section: Discussionmentioning

confidence: 99%

Integrating network pharmacology and pharmacological evaluation to investigate the anticancer effects of Duranta erecta Linn. Verbenaceae in breast cancer

Agbana¹,

Abu²,

Akinleye³

et al. 2023

Preprint

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Objective Breast cancer is the most prevalent type of cancer among women in sub-Saharan Africa. Efforts are being made to tackle the disease. However, numerous challenges are still reported. Duranta erecta showed medicinal relevance in different ailments but its molecular mechanism of action in breast cancer is not unraveled. The objective of this study is to evaluate the anticancer effect of Duranta erecta on breast cancer cells and determine the molecular mechanism of action in silico. Materials and Methods The Phytochemical Interaction Database, published literature, and the Swiss TargetPrediction database, respectively, were used to identify the active ingredients and targets of Duranta erecta. GEO datasets and TCGA databases were searched for breast cancer-related targets. A protein-protein interaction (PPI) network was constructed to screen the primary targets. For GO and KEGG pathway enrichment analyses, ShinyGO was used. By using molecular docking, interactions between potential targets and active substances were evaluated. MTT assay was conducted to evaluate the cytotoxicity effect of Duranta erecta. Results Duranta erecta demonstrated a cytotoxic effect on breast cancer cells. The IC50 values are 9.99 µg/mL and 15.07 µg/mL for the fruit extract and the leaves extract respectively. A total of 102 common targets and 77 active plant compounds were discovered, of which 37 are potential drug candidates. There were 10 hub targets identified by the PPI network. The hub targets are linked to pathways in cell proliferation and cancer. The best overall binding affinity was demonstrated by repenin A in binding with AURKA, CDK1, and EGFR. Conclusion This study was able to accurately predict the active ingredients and potential targets used in Duranta erecta's treatment of breast cancer. This study offers a fresh approach to future deeper studies on the molecular mechanisms of the plant and its compounds in breast cancer.

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Section: Discussionmentioning

confidence: 99%

Integrating network pharmacology and pharmacological evaluation to investigate the anticancer effects of Duranta erecta Linn. Verbenaceae in breast cancer

Agbana¹,

Abu²,

Akinleye³

et al. 2023

Preprint

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show abstract

“…The effect of the drug GTG may be possibly due to reinstatement of the pancreatic cells or decreased intestinal absorption of glucose, enhanced uptake of glucose in cells, inhibition of progress of advanced glycated end-products, increase in liver glycogen and glucokinase activity, and antioxidant effects [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Anti-hyperglycemic, anti-hyperlipidemic, and anti-inflammatory effect of the drug Guggulutiktaka ghrita on high-fat diet-induced obese rats

Sheik

Bakthavatchalam

Shenoy

et al. 2022

Journal of Ayurveda and Integrative Medicine

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“…D. erecta hydroponics were of potential use for the removal of domestic pathogens from wastewater [ 2 ]. This flowering shrub (frequently named as golden dewdrop or sky flower or angel whisper or pigeon berry) is cultivated worldwide for its medicinal uses, which includes vermifuge [ 3 ], antiviral [ 4 ], antimicrobial [ 5 ], urolithiasis [ 6 ], antioxidant [ 5 , 7 , 8 , 9 ], anticancer [ 10 , 11 ], antimalarial [ 12 ], anticoagulant [ 13 ], antihyperglycemic [ 14 , 15 , 16 ], larvicidal [ 17 ], and antifungal [ 10 , 18 ] activities. However, most of the reported pharmacological effects were performed on the plant alcoholic extract rather than on its oil or n -hexane fraction [ 8 , 9 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Antioxidant and Enzyme Inhibitory Potential of n-Hexane-Extracted Oils Obtained from Three Egyptian Cultivars of the Golden Dewdrop Duranta erecta Linn. Supported by Their GC-MS Metabolome Analysis and Docking Studies

et al. 2022

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Duranta erecta Linn. has a longstanding history for use in folk remedy for several disorders. Its hydroalcoholic extract has been investigated intensely in the treatment of many ailments, but to date very few data are presented to explain the pharmacological use of its oil. In this study, the chemical profiles of the leaf oils extracted from three Egyptian Duranta erecta cultivars, namely ‘Green’, ‘Golden edge’, and ‘Variegata’ are traced using GC-MS analysis. D. erecta ‘Green’ showed predominance of vitamin E (22.7%) and thunbergol (15%) whereas D. erecta ‘Golden edge’ and ‘Variegata’ contained tetratetracontane as a major component in their oils. The highest phenolic and flavonoid contents, displayed as gallic acid and rutin equivalents per gram oil, respectively, were observed in the ‘Golden edge’ and ‘Variegata’ cultivars, which was reflected by their strong DPPH and ABTS scavenging activities as well as the highest reducing power in both CUPRAC and FRAP assays. D. erecta ‘Green’ displayed better metal chelating potential, which may be attributed to its content of vitamin E. All cultivars showed similar enzyme inhibitory profiles. The best inhibition of α-glucosidase and α-amylase was observed by D. erecta ‘Green’. In silico studies of the major constituents docked on the active sites of the target enzymes NADPH oxidase, amylase, glucosidase, butyrylcholinesterase, and tyrosinase revealed high binding scores, which justified the biological activities of the tested oils.

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Anti-hyperglycemic and anti-dyslipidemic activities of methanol ripe fruit extract of Duranta erecta L (Verbenaceae) in normoglycemic and hyperglycemic rats

Abstract: Graphical abstract

Cited by 6 publications

References 26 publications

Integrating network pharmacology and pharmacological evaluation to investigate the anticancer effects of Duranta erecta Linn. Verbenaceae in breast cancer

Integrating network pharmacology and pharmacological evaluation to investigate the anticancer effects of Duranta erecta Linn. Verbenaceae in breast cancer

Anti-hyperglycemic, anti-hyperlipidemic, and anti-inflammatory effect of the drug Guggulutiktaka ghrita on high-fat diet-induced obese rats

The Antioxidant and Enzyme Inhibitory Potential of n-Hexane-Extracted Oils Obtained from Three Egyptian Cultivars of the Golden Dewdrop Duranta erecta Linn. Supported by Their GC-MS Metabolome Analysis and Docking Studies

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