Anti-hyperglycemic and Anti-hyperlipemia Effects of Syzygium Cumini Seed in Alloxan Induced Diabetes mellitus in Swiss Albino Mice (Mus musculus)

Sufiyan, Mohd

doi:10.4172/2167-0412.1000166

Cited by 6 publications

(4 citation statements)

References 38 publications

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“…99 The aqueous extract of Jamun seeds has also been reported to reduce serum glucose levels in alloxan-induced diabetes in mice. 100 In human diabetic subjects, supplementation of Jamun seed powder for 30 days reduced the fasting and post-prandial blood glucose levels. 101 The results from these collective studies indicate that Jamun seeds possess the ability to control blood sugar in the diabetic condition ( Table 3).…”

Section: Antidiabetic Activitymentioning

confidence: 99%

“…97 Aqueous seed extract of Jamun reduced the hyperlipidemic effect in alloxan-treated mice, by alleviating the enhanced levels of triglycerides, increasing the HDL cholesterol level, and returning the total cholesterol to normal. 100 Finally, the ethanol extracts of seeds and fruits of Jamun have been reported to decrease the enhanced levels of triglycerides and LDL and to increase the HDL cholesterol level in rats fed with a high cholesterol diet. 102 …”

Section: Antihyperlipidemic Activitymentioning

confidence: 99%

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Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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Plants have been employed as medicine since time immemorial, and there has been a recent resurgence in the use of plants as medicines due to their little or no toxicity at the doses used for treatment of different ailments. This review discusses in detail the phytochemical and pharmacological activities of Jamun (Syzygium cumini), a tree belonging to family Myrtaceae, which has been credited with several medicinal properties in the traditional system of medicine, the Ayurveda. The different properties attributed to Jamun are sweet, sour, astringent, acrid, refrigerant, carminative, diuretic, and digestive. Research and practical use in traditional medicinal systems have found Jamun to be effective in treating leucorrhoea, gastric disorders, fever, diabetes, piles, stomachache, wounds, and dental, digestive and skin disorders. Some compounds in Jamun have antioxidant, antimicrobial, antiallergic, antidiabetic, antihyperlipidemic, anticancer, gastroprotective, hepatoprotective, cardioprotective and radioprotective activity. Finally, Jamun has been found to contain phytochemicals including anthroquinones, alkaloids, catechins, flavonoids, glycosides, steroids, phenols, tannins, saponins and cardiac glycosides. The diverse activities of Jamun may be due to its abilities to scavenge free radicals, increase antioxidant status of cells by increasing glutathione, glutathione peroxidase, catalase and/or superoxide dismutase, and to attenuate lipid peroxidation. In addition, it also suppresses the transcription of peroxisome proliferator-activated receptor, Nuclear factor kappa B, cyclooxygenase, inducible nitric oxide synthase, tumor necrosis factor alpha and other proinflammatory cytokines, accompanied by the up-regulation of nuclear factor erythroid 2-related factor 2 transcription, which is involved in regulating the antioxidant status of the cells.

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Section: Antidiabetic Activitymentioning

confidence: 99%

Section: Antihyperlipidemic Activitymentioning

confidence: 99%

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Jagetia¹

2017

Journal of Exploratory Research in Pharmacology

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“…57 The administration of an aqueous extract of Jamun seeds in alloxan-induced diabetic mice reduced glucose level in the serum. 58 The Jamun fruit pulp/seed/kernel extracted in methanol reduced the activity of α-amylase, and the greatest inhibition of α-amylase activity was recorded for kernel extract in vitro. 59 Feeding diet consisting of Jamun fruits and seeds extracted in 50% ethanol for 60 days to diabetic rats led to attrition in serum glucose levels and a rise in insulin levels.…”

Section: Antidiabetic Activitymentioning

confidence: 94%

“…51 Jamun seed water extract prevented hyperlipidemia by bringing the total cholesterol and triglycerides levels to normal and elevating the HDL-c in the alloxan-induced diabetic mice. 58 The feeding of high cholesterol diet and Jamun seed and fruit ethanol extract to rats diminished triglycerides, and LDL-c and increased the HDL-c. 71 Administration of fruit pulp extract of Jamun to streptozotocininduced diabetic rats caused a similar effect. 56 The administration of triterpenoid-rich Jamun fruit extract (60 mg/mouse) once daily for ten days to streptozotocin-induced diabetic C57BL/6 mice resulted in a decline in the serum free fatty acid (FFA) contents and triglyceride and also in the liver of diabetic mice.…”

Section: Antihyperlipidemic Activitymentioning

confidence: 99%

Antidiabetogenic action of jamun syzygium cumini skeels: a review

Jagetia¹

2023

IJCAM

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This review delineates the utility of Jamun, Syzygium cumini in the treatment of diabetes and hyperlipidemia. The has been written by making thorough internet search on google scholar, PubMed, SciFinder, Science direct and many other websites. Diabetes is a common disorder inflicting children and adults equally. Diabetes mellitus is mainly of two types insulin dependent (IDDM-Type I) and non-insulin-dependent diabetes mellitus (NIDDM, Type II). The Type I diabetes is more common in children, whereas the Type II diabetes highly prevalent inflicting adults more. Jamun or Syzygium cumini belongs to family Myrtaceae and bears sweet fruits that are eaten as such or used to prepare juice, jam, and cookies. Jamun is considered as a Hoy tree which grows in India, Bangladesh Ceylon, Myanmar and Pakistan and is used in traditional medicine to treat diabetes. Jamun contains cardiac glycosides, anthraquinones, catechins, alkaloids, flavonoids, glycosides, steroids, phenols, tannins, and saponins. In Ayurveda, Jamun has been used for the treatment of diabetes since ancient times. Numerous preclinical and clinical investigations have validated the use of Jamun as an effective treatment regimen against diabetes. Jamun inhibits different free radicals and increases phase-I enzymes and reduces lipid peroxidation. It also activates PPARα, PPARγ, and AKT, and alleviates the expression of ACC1, Foxo-1, PGC1α, Scid 1, SREPB1c, endoplasmic reticulum protein retention receptor (KEDL), and GPR98 and causes depletion in activities of glucose 6-phosphataseadenosine deaminase, 5'-nucleotidase, phosphorenolpyruvate carboxykinase, and fatty acid synthase at the molecular level that may be responsible to cure diabetic condition.

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Biomarkers in Experimental Diabetes: Studies with Syzygium Cumini (L.) and Links with the Sulfonylurea 1 Receptor

Nadig¹,

K²,

J³

et al. 2022

Biomarkers in Disease: Methods, Discoveries and Applications

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Anti-hyperglycemic and Anti-hyperlipemia Effects of Syzygium Cumini Seed in Alloxan Induced Diabetes mellitus in Swiss Albino Mice (Mus musculus)

Cited by 6 publications

References 38 publications

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Phytochemical Composition and Pleotropic Pharmacological Properties of Jamun, Syzygium Cumini Skeels

Antidiabetogenic action of jamun syzygium cumini skeels: a review

Biomarkers in Experimental Diabetes: Studies with Syzygium Cumini (L.) and Links with the Sulfonylurea 1 Receptor

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