Anti-hyperglycemic and hypolipidemic effects of baechukimchi with Ecklonia cava in type 2 diabetic db/db mice

Lee, Hyunah; Park, Mi‐Hwa; Song, Yeonsu; Jang, Mi-Soon; Han, Ji-Sook

doi:10.1007/s10068-015-0041-z

Cited by 3 publications

(2 citation statements)

References 32 publications

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“…The data on glycogen were displayed in Table ( 5), where a significant increase was seen in the standard group. These results were in agreement with those of Lee et al (2015) who discovered that after the study period, the body weight of rat in the positive control group was considerably (p<0.05) higher than that of rat in the diabetic group. There was a significant increase in body weight by 37.96% in the standard group(C), In comparison, it increased by 13.41% in the group taking methanolic extract from Sargussium sp 150mg/kg algae to 15.03% in the group taking an water extract from Laurencia Papillose 150mg/kg algae.…”

Section: Effect Of the Tested Extracts Algae On Serum Enzymes Activit...supporting

confidence: 93%

Antidiabetic Activity of the Different Extracts of Some Algae on Streptozotocin-Induced Diabetic Rats

Fouda¹

2023

Annals of Agricultural Science, Moshtohor

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The algae Sargassum Petefollum (brown), Laurencia Papillose (red), and Cystoseira Myrica (brown) were used in this study to prepare extracts to improve the biological properties (for diabetic rats). Streptozotocin (STZ), 40 mg/kg rat weight was administered to raise the glucose level of rats. They were given 150 mg/kg of rat weight of the algae extracts under investigation. The injection process resulted in a significant increase in blood sugar from 87.67± 2.05 mg/dl in the control group to 331± 3.74 mg/dl in the diabetic group, Diabetic rat groups induced by STZ resulted in an increase in blood sugar level, and a significant decrease in insulin (0.42 ±0.02µ U/ml). The data showed that the an increase in the lipids profile, liver and kidney functions, and a decrease in activity of antioxidant enzymes compared to the control group, and after treatment with algae extracts used, whether brown or red. The results for all types of algae extracts showed an improvement in the biological properties. The results showed that brown algae (Cystoseira Myrica) had more influence on the biological properties, and decrease in blood sugar level was 203.33±2.87 mg/dl to112.00±6.38 mg/dl in methanol extract of Cystoseira Myrica and a significant increase in insulin (2.82± 0.07µ U/ml) and beneficial cholesterol HDL, was 49.05±3.39mg/dl. Also, cleared a significant decrease in lipids profile, a significant decrease in liver and kidney functions, and a significant increase in antioxidant enzymes, compared to the diabetic group. Finally, this study demonstrates the importance of using algae as a natural source of anti-diabetic compounds. Some effective compounds can be extracted and used as diabetes medications.

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Section: Effect Of the Tested Extracts Algae On Serum Enzymes Activit...supporting

confidence: 93%

Antidiabetic Activity of the Different Extracts of Some Algae on Streptozotocin-Induced Diabetic Rats

Fouda¹

2023

Annals of Agricultural Science, Moshtohor

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“…The weights of the liver and kidney tissues in the DC group were higher than those in the NC group, but tended to decrease following the intake of the AG group. Polydipsia, polyuria, and polyphagia are typical symptoms observed in diabetes (32). Yamanaka et al (33) reported that treatment with rosiglitazone increased the body weight of db/db mice.…”

Section: Resultsmentioning

confidence: 99%

Antioxidative and antidiabetic effects of germinated rough rice extract in 3T3-L1 adipocytes and C57BLKS/J-db/db mice

Lee

Jang

et al. 2019

Food & Nutrition Research

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BackgroundTo overcome disadvantages of germinated brown rice, we germinated rough rice and tested effects of its useful ingredients on prevention of diabetes.ObjectiveThis study investigated the in vitro antioxidant and in vivo antidiabetic effects of rough rice (Oryza sativa L.) with hulls, before and after germination. Rough rice was germinated for 4 days and extracted with water at 120°C.DesignThis study measured antioxidants and antioxidative effects and inhibitory activities against α-amylase and α-glucosidase of rough rice before and after germination and investigated antidiabetic effects of rough rice through animal experiments.ResultsAll these factors increased after germination. Also, α-amylase and α-glucosidase inhibition and glucose uptake by 3T3-L1 adipocytes were significantly increased after germination. Oral administration of the germinated rough rice extract for 8 weeks significantly increased insulin levels and decreased blood glucose levels in a C57BLKS/J-db/db mice model. Immunohistochemical analysis showed that germinated rough rice effectively protected against liver, kidney, and pancreatic tissue damage.DiscussionUseful ingredients in germinated rough rice could be used to prevent diabetes.ConclusionsThese results suggest that germinated rough rice extract had a beneficial effect on diabetes by increasing the antioxidant activity and further purification studies are necessary to elucidate the mechanism of the extract’s antidiabetic activity.

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The improvements of functional ingredients from marine foods in lipid metabolism

Wang

Xue

Zhang

et al. 2018

Trends in Food Science & Technology

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Anti-hyperglycemic and hypolipidemic effects of baechukimchi with Ecklonia cava in type 2 diabetic db/db mice

Cited by 3 publications

References 32 publications

Antidiabetic Activity of the Different Extracts of Some Algae on Streptozotocin-Induced Diabetic Rats

Antidiabetic Activity of the Different Extracts of Some Algae on Streptozotocin-Induced Diabetic Rats

Antioxidative and antidiabetic effects of germinated rough rice extract in 3T3-L1 adipocytes and C57BLKS/J-db/db mice

The improvements of functional ingredients from marine foods in lipid metabolism

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