Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract

Hsu, Yi-Jou; Lee, Tsung‐Han; Chang, Ching‐Cheng; Huang, Yuh-Ting; Yang, Wu-Chang

doi:10.1016/j.jep.2008.12.027

Cited by 88 publications

(81 citation statements)

References 10 publications

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“…In the present study, glimepiride significantly elevated serum insulin and significantly decrease serum glucose levels in STZ-diabetic rats. This result is in agreement with other authors 58 Furthermore, it lowered serum TBARS level. Hence, restoring the endogenous antioxidant defense capacity; our results were in accordance with the work of Kakadiya and Shah.…”

Section: Discussionsupporting

confidence: 94%

Modulatory Role of Selenium Nanoparticles and Grape Seed Extract Mixture on Oxidative Stress Biomarkers in Diabetic Irradiated Rats.

Abdelaleem¹,

Hameed²,

Askar³

et al. 2016

IJPER

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Introduction: Diabetes is a metabolic disorder of several etiologies, many oral anti-hyperglycemic agents such as sulfonylurea, biguanides are obtainable, but these agents have side effects, thus there is need of a new natural anti-hyperglycemic agent. Methods: The present study was performed to evaluate the protective role of selenium nanoparticles-grape seed extract (SeNPs-GSE) mixture in ameliorating the changes in the oxidative stress biomarkers induced by gamma radiation in diabetic rats. Experimental model of diabetic irradiated rats was induced by single intrapertoneal injection of streptozotocin (STZ 45 mg/kg) followed by γ-radiation exposure (4 Gy). Forty eight rats were randomly classified into 6 experimental groups: normal, diabetic, irradiated, diabetic irradiated, diabetic treated with either SeNPs-GSE mixtureor glimepiride(1 mg) for (14) days followed by γ-radiation. Results: Results of the present study indicated that rats exposed to γ-radiation and, or STZ significantly increase serum glucose& liver MDA levels. This increase was accompanied by a decrease in the levels of serum insulin, total antioxidant (TAC), liver enzyme activities of catalase (CAT), glutathione peroxidase (GPx), superoxide dismutase (SOD), as well as liver tissue contents of vitamin C (Vit.C) and vitamin E (Vit.E). Diabetic rats treated with (SeNPs-GSE) mixture or glimepiride before γ-radiation exert a significant improvement in all tested biochemical parameters. Conclusion:The present study showed that a mixture of (SeNPs -GSE) possesses antioxidant and anti-diabetic activities by decreasing oxidative stress biomarkers as well as blood glucose level tested in this study. The tested combination (SeNPs-GSE) mixture is more or less equally active as that of the standard tested anti-diabetic drug glimepiride

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Section: Discussionsupporting

confidence: 94%

Modulatory Role of Selenium Nanoparticles and Grape Seed Extract Mixture on Oxidative Stress Biomarkers in Diabetic Irradiated Rats.

Abdelaleem¹,

Hameed²,

Askar³

et al. 2016

IJPER

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“…Informer C also reported using Bidens pilosa to treat diabetes. Recent studies showed the anti-hyperglycemic properties of Bidens pilosa, the extracts of which decreased glucose and increased insulin levels in the serum of mice, corroborating the above-mentioned indication (Hsu et al, 2008;Chien et al, 2009). …”

Section: Resultssupporting

confidence: 64%

“…In addition, polyacetylenes from Bidens pilosa var. radiata seem also to present anti-diabetic and anti-hyperglicemic effects (Hsu et al, 2008;Chien et al, 2009). Furthermore, antibacterial, antifungal, antioxidant (Chiang et al, 2004Deba et al, 2007), antitumor (Kviecinski et al, 2008), antiulcer (Alvarez et al, 1999), vasorelaxant (Théophile et al, 2006 and immunomodulatory (Chiang et al, 2006;Chang et al, 2007) effects have been associated with Bidens pilosa compounds.…”

Section: Discussionmentioning

confidence: 99%

Bidens pilosa L. (Asteraceae): traditional use in a community of southern Brazil

Borges

Matos

Moreira

et al. 2013

Rev. bras. plantas med.

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RESUMO:Bidens pilosa Linn (Asteraceae): Uso tradicional em uma comunidade do Sul do Brasil. O emprego correto de plantas para fins terapêuticos pela população requer o uso daquelas selecionadas por sua eficácia e segurança, com base na tradição popular e/ ou cientificamente validadas como medicinais. Bidens pilosa L. é uma espécie que ocorre amplamente em regiões tropicais sendo conhecida no Brasil pelo nome popular "picão-preto". Quatro agentes da pastoral da Saúde foram identificadas na região de Criciúma/ SC por possuírem maiores informações de cunho popular sobre Bidens pilosa. A pesquisa ocorreu por meio de entrevista, onde foram compiladas informações sobre o conhecimento do "picão-preto", manuseio, farmacógeno, proporção farmacógeno/ solvente, técnica de preparo, formas de uso/posologia, indicações e restrições de uso. A forma farmacêutica utilizada variou significativamente, assim como a posologia. A análise de informações coletadas mostra a ação antiinflamatória como principal indicação terapêutica. Palavras-chave : planta medicinal, Bidens pilosa L., conhecimento popular, atividade antiinflamatória. ABSTRACT:The correct use of plants for therapeutic purposes requires selection of those showing efficacy and safety based on the popular tradition and/or scientific validation. Bidens pilosa L. is a species that widely occurs in tropical regions and is known in Brazil as "picão-preto". Four agents from the Health Pastoral Service were identified in the region of Criciuma, Santa Catarina State, for their popular knowledge of Bidens pilosa. The study was conducted by means of interview which provided data concerning the knowledge of "picão preto", handling, used plant part, plant/solvent proportion, preparation methods, administration route/dosage, indication and restrictions. The pharmaceutical form, as well as the posology, was significantly variable. Analysis of the collected data showed anti-inflammatory action as the main therapeutic indication.

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“…Nas últimas décadas, extensas investigações têm mostrado que essa espécie possui compostos com atividades anti-hiperglicêmicas (Ubillas et al, 2000;Hsu et al, 2009), antiúlceras (Tan et al, 2000), anti-inflamatórias (Khan et al, 2001), antitérmicas (Sundararajan et al, 2006), anticancerígenas e antitumorais (Sundararajan et al, 2006;Kviencinski et al, 2008), antioxidantes (Chiang et al, 2004), antivirais, antifúngicas (Deba et al, 2008) e antibacterianas (Khan et al, 2001 A inibição específica de bactérias entre as folhas e raízes dessa espécie pode, em parte, explicar por que a planta inteira é empregada no tratamento de infecções microbianas (Khan et al, 2001). Adicionalmente, compostos já relatados como eficazes no efeito alelopático a patógenos e/ou a outras espécies vegetais, como o poliacetileno PHT, flavonoides, alcaloides, esteroides, taninos, ácido linoleico e ácido linolênico, presentes em extratos de B. pilosa, possuem atividade antimicrobiana (Sundararajan et al, 2006).…”

Section: Uso Medicinal E Farmacologiaunclassified

Picão-preto: uma planta daninha especial em solos tropicais

Santos

Cury²

2011

Planta daninha

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RESUMO -Bidens pilosa está presente em praticamente todo o território brasileiro, além de vários outros habitats tropicais. Entre as características presentes na planta, a abundante e longa produção de propágulos, o fotoblastismo preferencial, o uso eficiente da água, a elevada extração e utilização de nutrientes, bem como características morfofisiológicas específicas, conferem vantagem na competição com as principais culturas anuais e perenes. Devido à plasticidade e flexibilidade adaptativa de B. pilosa e às interações de suas características na determinação da competitividade desse vegetal, torna-se difícil identificar aquelas que realmente se associam com elevada capacidade competitiva e que possuam maior expressividade. Dentro da espécie ocorrem biótipos resistentes a determinados herbicidas, o que dificulta seu controle nas áreas agrícolas. O uso de outros métodos de manejo também possui entraves, devido à ampla variação do fluxo de disseminação, germinação e emergência de propágulos e, ainda, às associações benéficas dessa espécie com microrganismos presentes no solo. Embora seja dotada de características que a tornam infestante agressiva nas áreas agrícolas, este trabalho reporta alguns mecanismos que podem ser usados para o manejo integrado da espécie. Além disso, B. pilosa apresenta propriedades medicinais, sendo necessário o aprofundamento científico para usufruto de seus benefícios.Palavras-chave: Asteraceae, Bidens pilosa, Manejo Integrado de Plantas Daninhas, polimorfismo germinativo, resistência a herbicidas.ABSTRACT -Bidens pilosa occurs in practically all the Brazilian territory, besides several other tropical habitats. This plant's most advantageous aspects in the competition with major annual and perennial cultivars are its abundant and long propagule production, preferential photo-blastism, water use efficiency, high nutrient extraction and use, and morphophysiological characteristics. Due to B. pilosas plasticity and adaptative flexibility, as well as interaction of the characteristics determining its competitiveness, it is difficult to identify those which are associated with higher competitive capacity and expressiveness. This species presents biotypes resistant to some herbicides, rendering its control difficult in agricultural areas. The use of other management methods is also difficult, due to the wide variation in the flow of propagule dissemination, germination and emergence, as well as the beneficial association of this weed with microorganisms present in the soil. Although this plant has aggressive infesting characteristics, this work has reported some mechanisms that can be used for its integrated management. B. pilosa also presents medical properties, with extensive scientific studies being necessary in order to obtain benefits.

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Anti-hyperglycemic effects and mechanism of Bidens pilosa water extract

Cited by 88 publications

References 10 publications

Modulatory Role of Selenium Nanoparticles and Grape Seed Extract Mixture on Oxidative Stress Biomarkers in Diabetic Irradiated Rats.

Modulatory Role of Selenium Nanoparticles and Grape Seed Extract Mixture on Oxidative Stress Biomarkers in Diabetic Irradiated Rats.

Bidens pilosa L. (Asteraceae): traditional use in a community of southern Brazil

Picão-preto: uma planta daninha especial em solos tropicais

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