Anti-hyperlipidemic activity of an extract from roots and rhizomes of Panicum repens L. on high cholesterol diet-induced hyperlipidemia in rats

Abstract

The hypolipidemic effect of an ethanolic extract from the roots and rhizomes of Panicum repens L. was investigated in rats suffering from high-cholesterol, diet-induced hyperlipidemia, and the phytochemicals in the extract were analyzed. The extract was administered p.o. in doses of 250 mg/kg/day together with cholesterol at a dose of 100 mg/kg/day for 7 weeks. The high-cholesterol diet caused a significant increase in total lipids, total cholesterol (TC), total triglycerides (TG), low-density lipoprotein cholesterol (LDL-C), and the atherogenic index, whereas the level of high-density lipoprotein cholesterol (HDL-C) was significantly decreased. Administration of the P. repens extract (p<0.05) significantly reduced the rise of the serum levels of total lipids, TC, TG, and LDL-C, as well as the atherogenic index, whereas it significantly increased (p<0.05) the level of HDL-C. HPLC analysis of the phenolics and flavonoids in the extract revealed the presence of gallic acid, chlorogenic acid, chicoric acid, primulic acid, rutin, apigenin-7-glucoside, and quercetin. In conclusion, the P. repens extract was found to possess hypolipidemic activity in high-fat, diet-induced hyperlipidemic rats.

Chicoric acid prevents PDGF-BB-induced VSMC dedifferentiation, proliferation and migration by suppressing ROS/NFκB/mTOR/P70S6K signaling cascade

“…In short, the left common carotid arteries were ligated with a 6.0 silk suture that was proximal to the carotid bifurcation for 8 weeks, and the uninjured right carotid arteries served as control. Three days after vascular injury, CA (50 mg/kg/day) was administered gastric gavage to rats for a total of 8 weeks as previously described [35] , [36] , [37] , [38] . At the end of experiments, the rats were sacrificed by overdose of pentobarbitalsodium (150 mg/kg, iv), and carotid arteries were harvested for hematoxylin and eosin (HE) staining and molecular biological analyses [39] , [40] .…”

Molecular Docking Study of Several Seconder Metabolites from Medicinal Plants as Potential Inhibitors of COVID-19 Main Protease

“…55 Kaempferol is another flavonoid derivative found in most edible plants such as tea, fruits, and vegetables consisting of Allium cepa L., Camellia sinensis (L.) Kuntze, Citrus paradisi Macfad., Fragaria vesca L., Lactuca sativa L., and in medicinal plants such as Tilia tomentosa Moench., Aloe vera L., Crocus sativus L., Vitis vinifera L., Ginkgo biloba L., Hypericum perforatum L., Phyllanthus acidus L., Ribes nigrum L., Rosmarinus officinalis L., Hippophae rhamnoides L., and Sambucus nigra L. 56 Antiviral activity of kaempferol on the influenza viruses (H1N1 and H9N2), HIV-1, flavivirus, two RNA viruses (murine norovirus and feline calicivirus), and human cytomegalovirus were mentioned. 14,48,51,57,58 Primulic acid is a saponin found in some species of Primulaceae [Primula officinalis L., P. elatior (L.) Hill, P. veris L.] and Poaceae (Panicum repens L.), [59][60][61][62][63] and was reported to have antiviral activity by Helal and Melzig. 58 Finally, cannabidiol, the potential inhibitor of COVID-19 M pro , purified from the C. sativa L., 64,65 and was reported to show high efficacy against viral hepatitis in previous studies.…”

Herbal Extracts Acting as Diuretics: A Comprehensive Review

“…The ethanolic extract derived from the roots and rhizomes of P. repens has demonstrated hypolipidemic activity. High-performance liquid chromatography (HPLC) identified the presence of gallic acid, chlorogenic acid, chicoric acid, primulic acid, rutin, apigenin-7-glucoside, and quercetin [63]. A study investigated the diuretic action of P. repens L. (ethanolic extract) in rats.…”