Anti-Hyperlipidemic Activity of Methanolic Extract of Boesenbergia Pandurata (Finger Root) in Experimental Induced Hypercholestrolemic Sprague Dawley Rats

Abstract

Objective: Hyperlipidemia is one of the risk factors that contribute to the prevalence of coronary heart diseases and antihyperlipidemic agents, such as statin, was used to treat hyperlipidemia as a current therapy. Boesenbergia pandurata has not been exploited for antihyperlipidemic effect. Hence, this study aims to screen for the antihyperlipidemic activity of methanolic extracts of B. pandurata rhizomes (BPR extracts) in hypercholesterolemia-induced Sprague-Dawley rats.Methods: BPR extracts were prepared using the maceration method with 1500 ml of 80% methanol at room temperature for about 7 days. A toxicity study was carried out based on OECD guidelines. Hypercholesterolemia was induced by 6% lard oil, 2% of cheese, and egg yolks. Two different doses of BPR extracts, 200 and 400 mg/kg, were used to screen for antihyperlipidemic effect. Histopathological study was carried out in the liver. The results were evaluated for the statistically significant difference by using the one-way ANOVA followed by post hoc Dunnett test.Results: No mortality was witnessed even till 2 g/kg. Only 400 mg/kg of BPR extracts statistically reduced in total cholesterol (p<0.05), low-density lipoprotein-cholesterol (p<0.05) and an increase in high-density lipoprotein-cholesterol (p<0.05) when compared to the positive control. BPR extracts (400 mg/kg) showed less enlargement of lipid droplets as compared to positive control.Conclusion: BPR extracts can be a promising medicinal plant for treating hyperlipidemia in underdeveloped countries.

Dietary Dracocephalum kotschyi essential oil improved growth, haematology, immunity and resistance to Aeromonas hydrophila in rainbow trout ( Oncorhynchus mykiss )

“…Owing to these problems, it seems necessary to replace antibiotics with safe alternatives. Dietary supplements, including plant‐based supplements, are currently used to keep health and to treat many diseases in humans and animals (Fattepur et al, 2018; Gondo, 2021; Othman et al, 2019; Roslan & Shariff, 2021; Shalaby, 2015, 2018; Shalaby, Sakoury, Harthi, et al, 2020; Shalaby, Sakoury, Kholif, et al, 2020; You et al, 2021; Zharif et al, 2018). During the last decade, many studies have reported the medicinal, antioxidant, immunogenic and antibacterial properties of medicinal plants and their derivatives in fish (Ahmadifar et al, 2019; Farsani et al, 2019; Rashidian, Bahrami Gorji, et al, 2020; Van Doan et al, 2020; Bibi et al, 2021; DeiviArunachalam et al, 2021; Ghafarifarsani Kachuei et al, 2021; Ghafarifarsani, Hoseinifar, Adorian, et al, 2021; Ghafarifarsani, Hoseinifar, Talebi, et al, 2021; Ghafarifarsani, Rashidian, et al, 2021; Qahir et al, 2021; Rashidian et al, 2021; Yousefi, Farsani, et al, 2021; Yousefi, Ghafarifarsani et al, 2021; Raissy et al, 2022; Yousefi et al, 2022).…”

The effect of calorie restricted diet on anthropometric and biochemical parameters in Sprague Dawley rats

“…This study used SD rats (n = 15) weighing 61.51 6 5.62 g (3 weeks old). They were each kept individually in standard animal housing at a controlled room temperature (22.24°C) with 12-h day/night cycle with free access to standard pellets, Gold Coin pallets (Port Klang, Malaysia) and tap water, ad libitum (Fattepur et al, 2018). The acclimatization period for the rats took 10 days after which all rats were weighed and divided into 3 experimental groups, namely, HCI (n = 5), MCI (n = 5) and LCI (n = 5).…”

Immunoglobulin and Oxidative Status Activities of Breast Meat in Broilers Fed Different Levels of Sodium Butyrate and Rosemary (Rosmarinus officinalis L) Leaf Meal

“…Large- scale and intensive industrial maintenance of livestock and poultry has increased the possibility of diseases, which to reduce the incidence of these diseases and also help increase growth and improve production traits of various chemicals, including antibiotics in poultry farms are used. Today, the use of medicinal plants due to its antimicrobial and antioxidant effects can be used to treat diseases [55][56][57][58][59][60][61].…”