Anti-hyperlipidemic effect of crude methanolic extracts of Glycine max (soy bean) on high cholesterol diet-fed albino rats

Uchendu, Ikenna Kingsley; Steven, Onwukwe Okechukwu; Agu, Chidozie Elochukwu; Orji, Oliver Chukwuma; Chekwube, Blessing Eluke; Nwosu, Tochi Faith

doi:10.5455/jmas.251532

Cited by 15 publications

(12 citation statements)

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“…The results were consistent with previous findings. Findings of a research by Uchendu Ikenna Kingsley on "The effect of methanolic extract of Glycine max (soy bean) on high cholesterol diet‐fed albino rats" indicated a significant decrease in LDL, TC, TG and an increase in serum HDL levels (Kingsley et al, ). Furthermore, E.S.…”

Section: Discussionmentioning

confidence: 99%

Comparative effects of quercetin and hydroalcoholic extract ofOtostegia persicaboiss with atorvastatin on atherosclerosis complication in male wistar rats

Parvin

Yaghmaei

Noureddini

et al. 2019

Food Science & Nutrition

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The use of herbal remedies is significantly considered in the atherosclerosis treatment, reduction of fatty elements, and prevention of activity of oxidative stress factors. The present study was conducted on 48 rats in 6 groups. The experimental and sham groups were fed with 2% cholesterol for 40 days; and experimental groups were separately treated by atorvastatin, quercetin, and hydroalcoholic extract for 4 weeks. After treatment procedure, some serum factors such as low‐density lipoprotein (LDL), total cholesterol (TC), malondialdehyde (MDA), and reactive oxygen species (ROS) were evaluated. Serum levels of LDL, TC, MDA, and ROS were significantly lower in experimental groups than sham group (p < .01). There was a significant decrease in serum MDA levels of these two groups in comparison with the atorvastatin‐treated group (p < .05). Blood pressure parameters were decreased in treated with quercetin and hydroalcoholic extract in comparison with the sham group (p < .05). Quercetin and hydroalcoholic extract similar to atorvastatin could decrease serum lipids [except high‐density lipoprotein (HDL)], oxidative stress factors, aorta contraction, weight gain, and blood pressure. These reagents improved the vascular structure and prevented the plaque formation.

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Section: Discussionmentioning

confidence: 99%

Comparative effects of quercetin and hydroalcoholic extract ofOtostegia persicaboiss with atorvastatin on atherosclerosis complication in male wistar rats

Parvin

Yaghmaei

Noureddini

et al. 2019

Food Science & Nutrition

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“…This metabolite, when in excess, depletes glutathione (GSH), the liver antioxidant and covalently binds to protein causing liver injury [5]. Some studies have shown that antioxidant-rich foods or food products have potential bioactive substances that exhibit protective properties [6][7][8][9][10]. The antioxidant in tomato may as well help to scavenge this free-radical, offering health benefit.…”

Section: Introductionmentioning

confidence: 99%

Untitled

2024

BEBA

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Introduction: It has been extensively reported that drug-overdose is the leading cause of liver injury in the world today. Diets rich in natural antioxidants have been observed to offer substantial remedy to drug-induced organ injuries. Objective: The aim of this study was to investigate the hepatoprotective effect of tomato extract against Acetaminopheninduced acute hepatotoxicity in rats. Method: Phytochemical analyses were performed. A total of 24 albino rats weighing (110±10g) were randomly allocated to four groups (A-D), with six rats per group. Group A was the normal control and received no treatment. Group B was the negative control and received a single dose of acetaminophen (750 mg/kg, i.p) only. Group C served as test group and received a single dose of acetaminophen (750 mg/kg, i.p.) before treatment with tomato extract (30 mg/kg, oral) for 14 consecutive days. Group D received simultaneous administration of tomato extract (30mg/kg, oral) and acetaminophen (750 mg/kg, i.p) for 14 days. Results: The single dose of Acetaminophen caused liver cell injuries with significant increase in the levels of the liver enzymes: AST (67.67±11.41U/L); ALT (46.33±10.59U/L) and ALP (223.70±23.31U/L) in rats in negative control when compared with normal (p<0.05 or p<0.01). The daily administration of the tomato extract was able to attenuate the acetaminophen-induced hepatotoxicity on the liver enzyme marker levels: In Group C: AST (23.00± 3.61U/L, P<0.01);

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“…It also contains phytochemicals: alkaloids, saponins, tannins, steroid, glucosides, flavonoids, glycosides [5]. Some studies have shown that antioxidant-rich foods or food products have potential bioactive substances that exhibit protective properties [6][7][8][9][10][11][12][13]. The antioxidants in Vernonia amygdalina may as well help to scavenge this free-radical, offering health benefit.…”

Section: Introductionmentioning

confidence: 99%

Effect of Aqueous Extract of Bitter Leaf (Vernonia Amygdalina) Against Acetaminophen-Induced Liver Damage in Rats

Ik¹

2018

BEBA

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Objective: The hepatoprotective effect of aqueous extract of Vernonia amygdalina on acetaminophen-induced liver damage in abino wistar rats was evaluated. Method: Twenty five (25) albino rats weighing (120±20g) were randomly divided into five (5) groups with five (5) rats per group. Group A served as normal control and received no treatment. Group B received only a single dose of acetaminophen (750mg/kg, i.p) and served as negative control. Group C served as positive control and received Vitamin C (200mg/kg, oral) for 2 weeks, while Group D and E served as the test groups and received aqueous bitter leaf extract; high dose (500mg/kg,oral) and low dose (250mg/kg, oral) separately for 2 weeks following acetaminophen challenge. Results: The administration of single dose of acetaminophen (750mg/kg, i.p) resulted in liver damage with AST, ALT and

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Anti-hyperlipidemic effect of crude methanolic extracts of Glycine max (soy bean) on high cholesterol diet-fed albino rats

Cited by 15 publications

References 0 publications

Comparative effects of quercetin and hydroalcoholic extract ofOtostegia persicaboiss with atorvastatin on atherosclerosis complication in male wistar rats

Comparative effects of quercetin and hydroalcoholic extract ofOtostegia persicaboiss with atorvastatin on atherosclerosis complication in male wistar rats

Untitled

Effect of Aqueous Extract of Bitter Leaf (Vernonia Amygdalina) Against Acetaminophen-Induced Liver Damage in Rats

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