Anti-hypersensitivity effects of Shu-jing-huo-xue-tang, a Chinese herbal medicine, in CCI-neuropathic rats

Shu, Haihua; Arita, Hideko; Hayashida, Masakazu; Zhang, Liang; An, Kai Nan; Huang, Wenqi; Hanaoka, Kazuo

doi:10.1016/j.jep.2010.07.004

Cited by 27 publications

(16 citation statements)

References 33 publications

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“…It has been used traditionally to remove blood stasis and quicken blood circulation. Experimentally, it was found to suppress neuropathic pain behaviors in rats with chronic constriction injury of the sciatic nerve (Shu et al, 2010). Many of the herbal formulas identified in our study also contained ingredients that could relieve pain or inhibit inflammation.…”

Section: Discussionmentioning

confidence: 63%

Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study

Liao

Yeh

Lin

et al. 2015

Journal of Ethnopharmacology

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Section: Discussionmentioning

confidence: 63%

Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study

Liao

Yeh

Lin

et al. 2015

Journal of Ethnopharmacology

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“…A large body of evidence indicates that in traditional Chinese medicine a plethora of herbs and herbal extracts are effective in the treatment of vascular diseases, for example, chronic wounds, diabetic retinopathy, and rheumatoid arthritis . Icariin is a major flavonoid isolated from the traditional oriental herbal medicine Epimedium koreanum Nakai, which exerts a broad range of biological efficacy, for example, in the context of osteoporosis, cardiovascular diseases, and immunological function regulation .…”

Section: Introductionmentioning

confidence: 99%

Icariin Promotes Angiogenic Differentiation and Prevents Oxidative Stress-Induced Autophagy in Endothelial Progenitor Cells

et al. 2015

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Reduced tissue levels of endothelial progenitor cells (EPCs) and functional impairment of endothelium are frequently observed in patients with diabetes and cardiovascular disease. The vascular endothelium is specifically sensitive to oxidative stress, and this is one of the mechanisms that causes widespread endothelial dysfunction in most cardiovascular diseases and disorders. Hence attention has increasingly been paid to enhance mobilization and differentiation of EPCs for therapeutic purposes. The aim of this study was to investigate whether Icariin, a natural bioactive component known from traditional Chinese Medicine, can induce angiogenic differentiation and inhibit oxidative stress-induced cell dysfunction in bone marrow-derived EPCs (BMEPCs), and, if so, through what mechanisms. We observed that treatment of BM-EPCs with Icariin significantly promoted cell migration and capillary tube formation, substantially abrogated hydrogen peroxide (H 2 O 2 )-induced apoptotic and autophagic programmed cell death that was linked to the reduced intracellular reactive oxygen species levels and restored mitochondrial membrane potential. Icariin downregulated endothelial nitric oxide synthase 3, as well as nicotinamide-adenine dinucleotide phosphate-oxidase expression upon H 2 O 2 induction. These antiapoptotic and antiautophagic effects of Icariin are possibly mediated by restoring the loss of mammalian target of rapamycin /p70S6K/4EBP1 phosphorylation as well as attenuation of ATF2 and ERK1/2 protein levels after H 2 O 2 treatment. In summary, favorable modulation of the angiogenesis and redox states in BM-EPCs make Icariin a promising proangiogenic agent both enhancing vasculogenesis and protecting against endothelial dysfunction.

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“…A large body of evidence indicates that in traditional Chinese medicine (TCM) a plethora of herbs and herbal extracts are effective in the treatment of vascular diseases such as chronic wounds, diabetic retinopathy and rheumatoid arthritis (Shu et al, 2010;Zhai et al, 2013). Thus, it seems rational to explore these medicinal plants as potential sources of novel angiomodulatory factors.…”

Section: Introductionmentioning

confidence: 99%

Salidroside exerts angiogenic and cytoprotective effects on human bone marrow‐derived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signalling pathways

Tang

Vater

Jacobi

et al. 2014

British J Pharmacology

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Background and Purpose With the increase of age, increased susceptibility to apoptosis and senescence may contribute to proliferative and functional impairment of endothelial progenitor cells (EPCs). The aim of this study was to investigate whether salidroside (SAL) can induce angiogenic differentiation and inhibit oxidative stress‐induced apoptosis in bone marrow‐derived EPCs (BM‐EPCs), and if so, through what mechanism. Experimental Approach BM‐EPCs were isolated and treated with different concentrations of SAL for up to 4 days. Cell proliferation, migration and tube formation ability were detected by DNA content quantification, transwell assay and Matrigel‐based angiogenesis assay. Gene and protein expression were assessed by qRT‐PCR and Western blot respectively. Key Results Treatment with SAL promoted cellular proliferation and angiogenic differentiation of BM‐EPCs, and increased VEGF and NO secretion, which in turn mediated the enhanced angiogenic differentiation of BM‐EPCs. Furthermore, SAL significantly attenuated hydrogen peroxide (H2O2)‐induced cell apoptosis, reduced the intracellular level of reactive oxygen species and restored the mitochondrial membrane potential of BM‐EPCs. Moreover, SAL stimulated the phosphorylation of Akt, mammalian target of rapamycin and p70 S6 kinase, as well as ERK1/2, which is associated with cell migration and capillary tube formation. Additionally, SAL reversed the phosphorylation of JNK and p38 MAPK induced by H2O2 and suppressed the changes in the Bax/Bcl‐xL ratio observed after stimulation with H2O2. Conclusions and Implications These findings identify novel mechanisms that regulate EPC function and suggest that SAL has therapeutic potential as a new agent to enhance vasculogenesis as well as protect against oxidative endothelial injury.

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Anti-hypersensitivity effects of Shu-jing-huo-xue-tang, a Chinese herbal medicine, in CCI-neuropathic rats

Cited by 27 publications

References 33 publications

Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study

Prescription patterns of Chinese herbal products for patients with fractures in Taiwan: A nationwide population-based study

Icariin Promotes Angiogenic Differentiation and Prevents Oxidative Stress-Induced Autophagy in Endothelial Progenitor Cells

Salidroside exerts angiogenic and cytoprotective effects on human bone marrow‐derived endothelial progenitor cells via Akt/mTOR/p70S6K and MAPK signalling pathways

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