Anti-hypertensive and cardioprotective activities of traditional Chinese medicine-derived polysaccharides: A review

Xie, Miaotian; Tao, Weili; Wu, Fengjia; Wu, Kunlin; Huang, Xiujie; Ling, Gensong; Zhao, Chi; Lv, Qian; Wang, Qiongjin; Zhou, Xianhuan; Ying, Chen; Yuan, Qin; Chen, Yicun

doi:10.1016/j.ijbiomac.2021.07.008

Cited by 39 publications

(9 citation statements)

References 131 publications

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“…It has been considered that polysaccharide, a kind of general term composed of polyhydroxyaldehyde or polyhydroxyketone and its derivatives and polymers, is one of the main pharmacodynamic substance bases in traditional Chinese medicine, and its content is closely related to its efficacy. 10,11 So, the results of polysaccharide content might indicate that the activity of RSP should be superior to that of CSP, but these results needed to be verified by subsequent anti-fatigue animal experiment.…”

Section: Resultsmentioning

confidence: 99%

Comparative Study of the Components and Anti-Fatigue Effect of Schisandra chinensis Polysaccharides from China and Russia

Han

Chen

Yuan

et al. 2022

Natural Product Communications

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Schisandra chinensis Bail. polysaccharides from China (CSP) and Russia (RSP) were separated by DEAE-52 cellulose column chromatography. The content of neutral polysaccharide was determined by the phenol concentrated sulfuric acid method, the content of acid polysaccharide by the hydroxybiphenyl method, and the monosaccharide composition and molecular weight arrangement of CSP and RSP by 1-phenyl-3-methyl-5-pyrazolone (PMP) pre-column derivatization HPLC. The effects of CSP and RSP on the exercise endurance of mice were compared by the forelimb grip strength test, rota-rod test and weight-bearing swimming. The results showed that one neutral polysaccharide and three acidic polysaccharides could be eluted from a DEAE-52 cellulose column from CSP and RSP, respectively. The content of acidic and neutral polysaccharides in RSP was higher than that in CSP, and the anti-fatigue effect of RSP was more significant than that of CSP.

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Section: Resultsmentioning

confidence: 99%

Comparative Study of the Components and Anti-Fatigue Effect of Schisandra chinensis Polysaccharides from China and Russia

Han

Chen

Yuan

et al. 2022

Natural Product Communications

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“…Besides, non-starch polysaccharides may improve health by regulating gut microbiota [ 14 ]. Moreover, polysaccharides deriving from traditional Chinese medicinal herbs have anti-hypertensive and cardioprotective activities and they also could be used as drug delivery systems to improve therapeutical effects by promoting bioavailability and reducing toxicity [ 15 , 16 ]. Two or three years ago, Yuan et al summarized the protective effects of polysaccharides in several types of liver injuries [ 11 ], and Qu et al reviewed the signaling pathways by which the plant polysaccharides regulate apoptosis and inflammation [ 12 ].…”

Section: Overview Of Liver Diseases and Polysaccharidesmentioning

confidence: 99%

The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases

Ren

Song

et al. 2022

Nutrients

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Liver disease is a global health burden with high morbidity and mortality worldwide. Liver injuries can develop into severe end-stage diseases, such as cirrhosis or hepatocellular carcinoma, without valid treatment. Therefore, identifying novel drugs may promote liver disease treatment. Phytochemicals, including polysaccharides, flavonoids, alkaloids, and terpenes, are abundant in foods and medicinal plants and have various bioactivities, such as antioxidation, immunoregulation, and tumor killing. Recent studies have shown that many natural polysaccharides play protective roles in liver disease models in vitro and in vivo, such as fatty liver disease, alcoholic liver disease, drug-induced liver injury, and liver cancer. The mechanisms of liver disease are complex. Notably, ferroptosis, a new type of cell death driven by iron and lipid peroxidation, is considered to be the key mechanism in many hepatic pathologies. Therefore, polysaccharides and other types of phytochemicals with activities in ferroptosis regulation provide novel therapeutic strategies for ferroptosis-related liver diseases. This review summarizes our current understanding of the mechanisms of ferroptosis and liver injury and compelling preclinical evidence of natural bioactive polysaccharides and phytochemicals in treating liver disease.

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“…Polysaccharides are among the main bioactive substances of Chinese herbal medicine and have a wide range of pharmacological effects, including antitumor effects ( Gan et al, 2020 ), antioxidant effects ( Wei et al, 2015 ), anticoagulant effects ( Zhao et al, 2012 ), effects in the treatment of ischemia-reperfusion injury ( Yuan et al, 2021 ), liver protection effects ( Qu et al, 2020 ), antiviral effects ( Cao et al, 2020 ), effects in the control of blood lipids ( Zhang et al, 2014 ), effects in the control of blood pressure ( Xie et al, 2021 ) and immunoregulatory effects ( Wang et al, 2021 ). Scutellaria barbata D. Don is a plant of the family Lamiaceae ( Yeon et al, 2015 ), and is listed in the 2015 edition of the Chinese Pharmacopoeia.…”

Section: Introductionmentioning

confidence: 99%

Extraction Optimization, Structural Characterization, and Anti-Hepatoma Activity of Acidic Polysaccharides From Scutellaria barbata D. Don

Qi-chao

et al. 2022

Front. Pharmacol.

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The Chinese medicinal herb Scutellaria barbata D. Don has antitumour effects and is used to treat liver cancer in the clinic. S. barbata polysaccharide (SBP), one of the main active components extracted from S. barbata D. Don, exhibits antitumour activity. However, there is still a lack of research on the extraction optimization, structural characterization, and anti-hepatoma activity of acidic polysaccharides from S. barbata D. Don. In this study, the optimal extraction conditions for SBP were determined by response surface methodology (RSM): the material-liquid ratio was 1:25, the extraction time was 2 h, and the extraction temperature was 90°C. Under these conditions, the average extraction efficiency was 3.85 ± 0.13%. Two water-soluble polysaccharides were isolated from S. barbata D. Don, namely, SBP-1A and SBP-2A, these homogeneous acidic polysaccharide components with average molecular weights of 1.15 × 105 Da and 1.4 × 105 Da, respectively, were obtained at high purity. The results showed that the monosaccharide constituents of the two components were fucose, galactosamine hydrochloride, rhamnose, arabinose, glucosamine hydrochloride, galactose, glucose, xylose, and mannose; the molar ratio of these constituents in SBP-1A was 0.6:0.3:0.6:30.6:3.3:38.4:16.1:8:1.4, and that in SBP-2A was 0.6:0.5:0.8:36.3:4.4:42.7:9.2:3.6:0.7. In addition, SBP-1A and SBP-2A contained uronic acid and β-glucan, and the residue on the polysaccharide was mainly pyranose. The in vitro results showed that the anti-hepatoma activity of SBP-2A was better than that of SBP-1A and SBP. In addition, SBP-2A significantly enhanced HepG2 cell death, as cell viability was decreased, and SBP-2A induced HepG2 cell apoptosis and blocked the G1 phase. This phenomenon was coupled with the upregulated expression of P53 and Bax/Bcl-2 ratio, as well as the downregulated expression of the cell cycle-regulating protein cyclinD1, CDK4, and Bcl-2 in this study. Further analysis showed that 50 mg/kg SBP-2A inhibited the tumour growth in H22 tumour-bearing mice, with an average inhibition rate of 40.33%. Taken together, SBP-2A, isolated and purified from S. barbata showed good antitumour activity in vivo and in vitro, and SBP-2A may be a candidate drug for further evaluation in cancer prevention. This study provides insight for further research on the molecular mechanism of the anti-hepatoma activity of S. barbata polysaccharide.

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Anti-hypertensive and cardioprotective activities of traditional Chinese medicine-derived polysaccharides: A review

Cited by 39 publications

References 131 publications

Comparative Study of the Components and Anti-Fatigue Effect of Schisandra chinensis Polysaccharides from China and Russia

Comparative Study of the Components and Anti-Fatigue Effect of Schisandra chinensis Polysaccharides from China and Russia

The Regulatory Roles of Polysaccharides and Ferroptosis-Related Phytochemicals in Liver Diseases

Extraction Optimization, Structural Characterization, and Anti-Hepatoma Activity of Acidic Polysaccharides From Scutellaria barbata D. Don

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