Anti-Hyperuricemic and Nephroprotective Effects of Rhein in Hyperuricemic Mice

Meng, Zhaoqing; Yan, Yun-Xia; Tang, Zhaohui; Guo, Chengjun; Li, Na; Huang, Wen-Zhe; Ding, Gang; Wang, Zhenzhong; Xiao, Wei; Yang, Zhonglin

doi:10.1055/s-0034-1396241

Cited by 52 publications

(36 citation statements)

References 26 publications

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“…Our results are consistent with Meng et al [ 44 ] who reported that rhein possesses various pharmacological activities, including anti-inflammatory, antioxidant, and antitumor. In their study, a model of hyperuricemia and nephropathy induced by adenine and ethambutol in mice was established.…”

Section: Discussionsupporting

confidence: 93%

Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats

Refaie

Amin

El‐Tahawy

et al. 2016

Journal of Toxicology

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Nephrotoxicity is one of the limiting factors for using doxorubicin (DOX). Interleukin 1 has major role in DOX-induced nephrotoxicity, so we investigated the effect of interleukin 1 receptor antagonist diacerein (DIA) on DOX-induced nephrotoxicity. DIA (25 and 50 mg/kg/day) was administered orally to rats for 15 days, in the presence or absence of nephrotoxicity induced by a single intraperitoneal injection of DOX (15 mg/kg) at the 11th day. We measured levels of serum urea, creatinine, renal reduced glutathione (GSH), malondialdehyde (MDA), total nitrites (NOx), catalase, and superoxide dismutase (SOD). In addition, caspase-3, tumor necrosis factor alpha (TNFα), nuclear factor kappa B (NFκB) expressions, and renal histopathology were assessed. Our results showed that DOX-induced nephrotoxicity was ameliorated or reduced by both doses of DIA, but diacerein high dose (DHD) showed more improvement than diacerein low dose (DLD). This protective effect was manifested by significant improvement in all measured parameters compared to DOX treated group by using DHD. DLD showed significant improvement of creatinine, MDA, NOx, GSH, histopathology, and immunohistochemical parameters compared to DOX treated group.

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Section: Discussionsupporting

confidence: 93%

Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats

Refaie

Amin

El‐Tahawy

et al. 2016

Journal of Toxicology

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“…Similarly, the increased activity of XO may also be an indirect measurement of serum uric acid level. Recently, association between hyperuricaemia and renal failure has also been reported (Meng et al, ; Ohashi et al, ). In addition, the observable reduction in both renal and cardiac NO also contributed significantly to the development of hypertension.…”

Section: Discussionmentioning

confidence: 91%

Sodium fluoride induces hypertension and cardiac complications through generation of reactive oxygen species and activation of nuclear factor kappa beta

Oyagbemi

Omobowale

Asenuga

et al. 2016

Environmental Toxicology

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Human exposure to sodium fluoride through its daily usage is almost inevitable. Cardiovascular and renal dysfunction has been associated with fluoride toxicity. Therefore, this study investigated the mechanism of action of sodium fluoride (NaF) induced hypertension and cardiovascular complications Forty male albino rats of an average of 10 rats per group were used. Group A received clean tap water. Toxicity was induced in Group B to D by administering graded doses of NaF through drinking water ad libitum for 10 days at 150 ppm, 300 ppm, and 600 ppm concentration respectively. Following administration of NaF, there was significant increase in systolic pressure, diastolic pressure and mean arterial pressure. Markers of oxidative stress; malondialdehyde, hydrogen peroxide, advance oxidation protein products, and protein carbonyl were significantly increased in dose-dependent pattern in the cardiac and renal tissues of rats together with significant decrease in the GST activity in NaF-treated rats compared to the control. Also serum markers of inflammation, cardiac, and renal damage including myeloperoxidase, xanthine oxidase, blood urea nitrogen, creatinine, Lactate dehydrogenase (LDH), and Creatinine kinase myocardial band (CK-MB) significantly increased indicating induction of oxidative stress, renal, and cardiac damage after exposure. Histopathology of the kidney and heart revealed aberrations in the histological architecture in NaF-treated rats. Also, immunohistochemistry showed higher expression of nuclear factor kappa beta (NF-kB) in the cardiac and renal tissues of rats administered NaF. Combining all, these results indicate NaF-induced hypertension through generation of reactive oxygen species and activation of renal and cardiac NF-kB expressions. © 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 1089-1101, 2017.

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“…Again, the increased serum activity of XO has been associated with oxidative stress through generation of ROS [54] and is also an indirect measurement of serum uric acid level [27] . Meng et al [55] and Ohashi et al [56] recently suggested a link between hyperuricaemia and renal failure which is a possibility following SMV exposure.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress changes observed in selected organs of African giant rats (Cricetomys gambianus) exposed to sodium metavanadate

Usende

Olopade

Emikpe

et al. 2018

International Journal of Veterinary Science and Medicine

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Vanadium is a contaminant of crude oil that released into the atmosphere through burning of fossil fuels. The mechanism by which it exerts toxic influences had not been fully elucidated in African giant rat (AGR). This study investigates the mechanisms of sodium metavanadate (SMV) induced oxidative stress in AGR. A total of 24 adult male AGR weighing 600–850 g were used. Animals were randomly divided into six groups. Groups 1, 3 and 5 served as control while groups 2, 4 and 6 were treated with intraperitoneal 3 mg/kg body weight of SMV for 3, 7 and 14 days, respectively. Serum, brain, liver, testes, kidneys, spleen and lungs were harvested for biochemical assays. SMV induced significant increase in malondialdehyde, hydrogen peroxide, sulfhydryl (total thiol) and protein carbonyl levels but decreased non-protein thiol levels in tissues accessed. A significant decrease was observed in glutathione-S-transferase (GST), superoxide dismutase (SOD), reduced glutathione (GSH) and glutathione peroxidase (GPx) levels in SMV treated rats compared to controls. Serum myeloperoxidase, xanthine oxidase and Advanced Oxidative Protein Products (AOPP) were markedly increased while nitrous oxide levels were significantly decreased in all treated groups. SMV exposure to AGR induced oxidative stress through generation of reactive oxygen species (ROS) and depletion of the antioxidant defence system. These conditions could become severe with prolonged exposure.

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Anti-Hyperuricemic and Nephroprotective Effects of Rhein in Hyperuricemic Mice

Cited by 52 publications

References 26 publications

Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats

Possible Protective Effect of Diacerein on Doxorubicin-Induced Nephrotoxicity in Rats

Sodium fluoride induces hypertension and cardiac complications through generation of reactive oxygen species and activation of nuclear factor kappa beta

Oxidative stress changes observed in selected organs of African giant rats (Cricetomys gambianus) exposed to sodium metavanadate

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