Anti-<i>Helicobacter pylori</i> activity and gastroprotective effects of human stomach-derived <i>Lactobacillus paragasseri</i> strain LPG-9

Xu, Binyan; Kong, Jingjing; Lin, Yangfan; Tang, Ziyu; Liu, Jiaxin; Chen, Zhenhui; Zeng, Weiseng; Bai, Yang; Fan, Hongying

doi:10.1039/d3fo03562j

Food Funct.

2023

DOI: 10.1039/d3fo03562j

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Anti-Helicobacter pylori activity and gastroprotective effects of human stomach-derived Lactobacillus paragasseri strain LPG-9

Binyan Xu,

Jingjing Kong,

Yangfan Lin

et al.

Abstract: The eradication of Helicobacter pylori is an urgent global issue. However, the traditional regimens have several limitations. Thus, we propose the idea of treating bacterial gastric disease with the objective...

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2024

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Cited by 3 publications

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Four novel anti-adhesive activity peptides against Helicobacter pylori derived from rice bran protein: release, identification and anti-adhesive mechanisms elucidation

Li,

Miao,

Liu

et al. 2024

Food Funct.

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Four novel anti-adhesive activity peptides against Helicobacter pylori derived from rice bran protein: release, identification and anti-adhesive mechanisms elucidation

Li,

Miao,

Liu

et al. 2024

Food Funct.

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Effects of Latilactobacillus sakeiLZ217 on Gastric Mucosal Colonization, Metabolic Interference, and Urease Expression in Helicobacter pylori Infection

Xia,

Chen,

Chen

et al. 2024

Helicobacter

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Emerging evidence suggests differential antagonism of lactic acid‐producing bacteria (LAB) to Helicobacter pylori, posing challenges to human health and food safety due to unclear mechanisms. This study assessed 21 LAB strains from various sources on H. pylori growth, urease activity, and coaggregation. Composite scoring revealed that Latilactobacillus sakei LZ217, derived from fresh milk, demonstrates strong inhibitory effects on both H. pylori growth and urease activity. L. sakei LZ217 significantly reduced H. pylori adherence of gastric cells in vitro, with inhibition ratios of 47.62%. Furthermore, in vivo results showed that L. sakei LZ217 alleviated H. pylori‐induced gastric mucosa damage and inflammation in mice. Metabolomic exploration revealed metabolic perturbations in H. pylori induced by L. sakei LZ217, including reduced amino acid levels (e.g., isoleucine, leucine, glutamate, aspartate, and phenylalanine) and impaired carbohydrate and nucleotide synthesis, contributing to the suppression of ureA (28.30%), ureE (84.88%), and ureF (59.59%) expressions in H. pylori. This study underscores the efficacy of LAB against H. pylori and highlights metabolic pathways as promising targets for future interventions against H. pylori growth and colonization.

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Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review

Kuang,

Xu,

et al. 2024

Front. Cell Dev. Biol.

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Chronic atrophic gastritis (CAG) is a prevalent digestive system disease characterized by atrophy of the gastric mucosa and the disappearance of inherent gastric glands. According to the theory of Correa’s cascade, CAG is an important pathological stage in the transformation from normal condition to gastric carcinoma. In recent years, the global incidence of CAG has been increasing due to pathogenic factors, including Helicobacter pylori infection, bile reflux, and the consumption of processed meats. In this review, we comprehensively described the etiology and clinical diagnosis of CAG. We focused on elucidating the regulatory mechanisms and promising therapeutic targets in CAG, with the expectation of providing insights and theoretical support for future research on CAG.

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Anti-Helicobacter pylori activity and gastroprotective effects of human stomach-derived Lactobacillus paragasseri strain LPG-9

Abstract: The eradication of Helicobacter pylori is an urgent global issue. However, the traditional regimens have several limitations. Thus, we propose the idea of treating bacterial gastric disease with the objective...

Cited by 3 publications

References 50 publications

Four novel anti-adhesive activity peptides against Helicobacter pylori derived from rice bran protein: release, identification and anti-adhesive mechanisms elucidation

Four novel anti-adhesive activity peptides against Helicobacter pylori derived from rice bran protein: release, identification and anti-adhesive mechanisms elucidation

Effects of Latilactobacillus sakeiLZ217 on Gastric Mucosal Colonization, Metabolic Interference, and Urease Expression in Helicobacter pylori Infection

Current study of pathogenetic mechanisms and therapeutics of chronic atrophic gastritis: a comprehensive review

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