Anti‐Helicobacter pylori activity of Chinese tea: in vitro study

Abstract

Background: Chinese tea has an antibacterial activity against a wide range of bacteria. However, its activity against Helicobacter pylori has not been reported. Method: In this study the anti‐Helicobacter pylori effects of a Chinese tea (Lung Chen tea), and two tea catechins, epigallocatechin gallate and epicatechin and their minimum inhibitory concentrations (MICs) were examined. The effect of Lung Chen on metronidazole resistance was also studied using the E‐test. Results: Lung Chen, epigallocatechin gallate and epicatechin all inhibited the growth of H. pylori. The MIC90 for Lung Chen was 0.25–0.5% (w/w) and that of epigallocatechin gallate and epicatechin were 50–100 and 800–1600 μg/mL, respectively. Epigallocatechin gallate is probably the active ingredient responsible for most of the anti‐H. pylori activity of Chinese tea. Lung Chen did not reverse metronidazole resistance. Conclusions: Chinese tea has anti‐H. pylori activity in a daily consumed concentration, and epigallocatechin gallate is probably the active ingredient responsible for the action.

Direct Evidence of Interaction of a Green Tea Polyphenol, Epigallocatechin Gallate, with Lipid Bilayers by Solid-state Nuclear Magnetic Resonance

“…Recently, they have been found to have various biological effects such as antimutagenicity, 1,2) anticarcinogenicity, 3) antitumorigenicity, 4,5) and antioxidant, [6][7][8] antihypercholesterolemia, 9) and antibacterial activities. [10][11][12][13] The biological activities of catechins have been evaluated by in vitro experiments using cultured cells or bacteria, but the order of activity was variable. The differences in biological activities may be attributed partly to the amounts of compounds incorporated into the lipid bilayers.…”

Evaluation of Epigallocatechin Gallate and Related Plant Polyphenols as Inhibitors of the FabG and FabI Reductases of Bacterial Type II Fatty-acid Synthase

“…Avid tea drinkers consume several cups a day, and although the potency of the catechins is low, the large quantities of the polyphenols that are ingested make it reasonable to think that they have potential for antibacterial activity. An example is the correlation between the in vivo and in vitro susceptibility of Helicobacter pylori to green tea (9,10).…”

Centaurea cyanus L. Polysaccharides and Polyphenols Cooperation in Achieving Strong Rat Gastric Ulcer Protection

“…Antimicrobial effect Anti-Helicobacter pylori activity Ponciretin, hesperetin, naringenin and diosmetin [45], tectorigenin, genistein, irigenin [46] as well as gallic acid derivates [47], epigallocatechingallates and epicatechingallates from green tea [48][49] or magnolol, berberine and cinnamic acid [50].…”