Anti-<i>Toxoplasma gondii</i>Antibodies in Haemodialysis Patients with Chronic Renal Failure

Yazar, Süleyman; Demirtaş, Funda; Yalçın, Şaban; Yaman, Ozan; Tokgöz, Bülent; Utaş, Cengiz; Şahi̇n, İzzet

doi:10.3349/ymj.2003.44.2.288

Cited by 19 publications

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“…This result is the same as that of Ocak et al (17) who studied hemodialysis patients and healthy volunteers in Turkey. On the other hand, Aufy et al (21), Sahinl et al (16), Maraghi et al (18), Ebrahim Zadeh et al (19) , Rezavand et al (20) and Nissaptorn et al (23) studies determined 16.7%, 6.8% , 8.6 %, 13.5%, 3.3% and 5.7% respectively in the patient groups, which is not compatible with our results.…”

Section: Discussioncontrasting

confidence: 90%

“…The results of the patient group share a similar frequency with figures reported in Turkey (76.5%) (17). However, the data in our study were higher than those reported by Sahinl et al (16) (59.1%) and Maraghi et al (18), Ebrahim Zadeh et al (19) and Rezavand et al (20) of 59.1% ,40.67% , 56.7% and 60%, respectively in Iran, and Aufy et al (21) and Alvarado-Esquivel et al (22) of 56.06%, 56.7% and 10%, respectively in Turkey, Egypt and Mexico; whereas in our results the percentage of Anti-Toxoplasma gondii IgG antibody in the volunteer group was more than other studies (17-22). Furthermore, in our study, there were no positive cases of anti- Toxoplasma gondii IgM antibody in the patient group and only 2.76% of the healthy volunteer showed the IgM antibody.…”

Section: Discussioncontrasting

confidence: 88%

“…These data were higher than those reported by Sahinl et al (16) across both groups. The outcome in our study was different from those reported in certain studies where such differences may have been related to local environmental conditions.…”

Section: Discussioncontrasting

confidence: 78%

“…Additionally, our study indicated that there was no significant association between anti- Toxoplasma gondii due to IgG antibody frequency and the duration of hemodialysis treatment in either sex, whereas such a correlation was shown in the studies of Sahinl et al (16) in Iran and Ocak et al (17) in Turkey.…”

Section: Discussioncontrasting

confidence: 77%

“…However the existence of Toxoplasma tissue cysts in hosts may contribute to the maintenance of immunity against reinfection, and their presence may also cause symptomatic toxoplasmosis under certain conditions, especially in infants with congenital toxoplasmosis and immunocompromised patients (15). Studies have shown that renal failure patients, such as those on hemodialysis, are immunodeficient, and such patients are therefore at high risk for numerous infections (16-18). …”

Section: Introductionmentioning

confidence: 99%

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Evaluation of Anti-Toxoplasma gondii Antibodies in Hemodialysis Patients with Chronic Kidney Disease in Sari, Iran

et al. 2016

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BackgroundToxoplasma gondii has worldwide distribution and is one of the most prevalent infectious agents in humans.ObjectivesThe aim of this study was to determine the prevalence of anti-Toxoplasma gondii antibodies in hemodialysis patients with chronic kidney disease (CKD) in the hemodialysis unit of Fatemeh Zahra hospital at the Mazandaran University of Medical Sciences in Sari, Iran.MethodsSeventy-three patients with CKD and 145 healthy volunteers were assessed for anti-Toxoplasma gondii (IgG, IgM, and IgA) antibodies using a conventional ELISA technique.ResultsThe anti-Toxoplasma gondii IgG antibody was detected in 80.8% of the cases in the patient group, while 31.5% of the cases in the CKD patient group and 31.8% in the control group were found to be positive for the anti-Toxoplasma gondii IgA antibody. All the patients in the CKD group were negative for the anti-Toxoplasma gondii IgM antibody, although 2.76% of the healthy volunteers were found to be positive. The present study suggests that there was no significant difference between the hemodialysis patient group and the healthy volunteers.ConclusionsThe epidemiological data collected in this study could serve as a reference for future studies and may be useful in developing preventive and educational strategies, and consequently reducing healthcare expenditure.

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Section: Discussioncontrasting

confidence: 90%

Section: Discussioncontrasting

confidence: 88%

Section: Discussioncontrasting

confidence: 78%

Section: Discussioncontrasting

confidence: 77%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Evaluation of Anti-Toxoplasma gondii Antibodies in Hemodialysis Patients with Chronic Kidney Disease in Sari, Iran

et al. 2016

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Detection of toxoplasmosis in patients with end-stage renal disease by enzyme-linked immunosorbent assay and polymerase chain reaction methods

et al. 2012

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Toxoplasmosis caused by Toxoplasma gondii is an opportunistic infection. In healthy individuals, the infection is largely asymptomatic, but in immunocompromised people the parasite can become widely disseminated, causing severe toxoplasmosis. In patients undergoing haemodialysis, the phagocytic process shows a highly significant impairment. Therefore, this study aimed to investigate toxoplasmosis in patients with end-stage renal disease (ESRD) undergoing haemodialysis in Ahvaz hospitals, southwest of Iran. A total of 280 patients and 100 healthy subjects participated in this study. The presence of serum IgM and IgG antibodies against T. gondii was detected by ELISA and the presence of Toxoplasma parasites in whole blood was evaluated by GRA6 PCR. Anti-T. gondii IgG antibodies were detected in 82 (29.3 %) haemodialysis patients and 26 (26 %) controls. In addition, anti-T. gondii IgM antibodies were detected in 7.9 % of patients and in 4 % of controls. For both the antibodies, the differences were statistically significant (P < 0.05). PCR was performed with DNA extracted from blood samples of all patients and controls. PCR gave positive results with four of the 280 blood samples from patients but none for the control blood samples. The results revealed a high percentage of positivity for Toxoplasma antibodies in patients with ESRD undergoing haemodialysis and also confirmed the parasite in whole blood, indicating disseminated infection in these patients. Patients undergoing dialysis have a higher rate of active infection with Toxoplasma likely due to reactivation of a chronic infection. Thus, parasitological examinations of ESRD patients should be periodically carried out for monitoring and evaluating the possible dissemination of toxoplasmosis during haemodialysis.

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Seroepidemiology and Associated Risk Factors of Toxoplasma gondii in Hemodialysis Patients

et al. 2020

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Purpose Immunocompromised patients may be at risk for reactivation of the toxoplasmosis infection, because of defection in cell-mediated immunity. Therefore, early diagnosis would be highly desirable in these individuals. This case-control study was designed to increase information about toxoplasmosis in hemodialysis (HD) patients in Guilan province, Iran. Methods The study was performed among 150 patients and 150 controls referred to hospitals of Guilan University of Medical Sciences during 2018-2019. Questionnaire forms, including demographic and epidemiological information, were completed. Peripheral blood samples were taken for serum separation and were collected into tubes and then kept at − 20 °C until use. IgG and IgM antibodies to Toxoplasma gondii were detected by a commercial ELISA kit. Accordingly, IgG absorbance levels < 9 were considered negative, 9-11 was considered borderline, and > 11 was positive; IgM absorbance levels < 0.9 were considered negative, 0.9-1.1 was assumed to be borderline, and > 1.1 was positive. Results Throughout the study, 72.0% of HD patients and 64.7% of the control group were positive for anti-Toxoplasma IgG antibody subsequently. 2% of HD patients and 0.7% of the control group were positive for anti-Toxoplasma IgM antibody and these difference weren't significant between control and ones with HD (P > 0.05). There was no significant difference between dialysis duration factor and the seropositivity rate. Seroprevalence of T. gondii infection did not vary significantly with age, educational level, residence and presence of a cat at home. On the contrary, seroprevalence varied significantly with gender and consumption of raw vegetables. Conclusion Because of the high percentage of positivity for Toxoplasma IgG antibodies in hemodialysis patients, we suggest a periodically screening program to carry out for monitoring and evaluating the possible dissemination of toxoplasmosis during hemodialysis.

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Anti-Toxoplasma gondiiAntibodies in Haemodialysis Patients with Chronic Renal Failure

Cited by 19 publications

References 0 publications

Evaluation of Anti-Toxoplasma gondii Antibodies in Hemodialysis Patients with Chronic Kidney Disease in Sari, Iran

Evaluation of Anti-Toxoplasma gondii Antibodies in Hemodialysis Patients with Chronic Kidney Disease in Sari, Iran

Detection of toxoplasmosis in patients with end-stage renal disease by enzyme-linked immunosorbent assay and polymerase chain reaction methods

Seroepidemiology and Associated Risk Factors of Toxoplasma gondii in Hemodialysis Patients

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