Anti-<i>Trichomonas vaginalis</i> activity of essential oils extracted from Caatinga Myrtaceae species and chemical composition of <i>Eugenia pohliana</i> DC.

Menezes, Saulo Almeida de; Galego, Giulia Bongiorni; Rigo, Graziela de Vargas; Aguiar, Júlio César de Oliveira Farias de Ribeiro; Veras, Bruno de Oliveira; Vandesmet, Lilian Cortez Sombra; Santos, Cícero Ramon Bezerra dos; Sampaio, Mariana Gomes Vidal; Marques, Clécia de Carvalho; Lermen, Vilmar Luiz; Navarro, Daniela Maria do Amaral Ferraz; Silva, Márcia Vanusa da; Correia, Maria Tereza dos Santos; Tasca, Tiana

doi:10.1080/14786419.2022.2101050

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Thus, new drugs for the treatment of trichomoniasis are highly needed, and natural products have gained prominence as therapeutic alternatives. Previous studies have shown that essential oils from Myrtaceae species have potential against T. vaginalis [31]. Our results corroborate with these studies and point to EOSC as promising in combating T. vaginalis (IC 50 : 88.2 µg/mL), highlighting the need for studies using α-pinene against metronidazole-sensitive isolates.…”

Section: Discussionsupporting

confidence: 90%

“…Trichomonads in the logarithmic growth phase exhibiting > 95% of normal motility and morphology were inoculated in fresh TYM for assays. The anti-T. vaginalis activity of EOSC was evaluated in vitro at concentrations ranging from 500 to 15.6 µg/mL, as described by Menezes et al [31]. The serial diluted EOSC (50 µL) was added to 96-well microplates with 2.0 × 10 5 trophozoites/mL suspensions (150 µL).…”

Section: Anti-trichomonas Vaginalis Activitymentioning

confidence: 99%

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In Vitro and In Silico Biological Evaluation of the Essential Oil from Syzigium cumini Leaves as a Source of Novel Antifungal and Trichomonacidal Agents

Silva,

Moreira,

Bezerra

et al. 2024

Future Pharmacology

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As microbes develop resistance to various drugs, the treatment of infections becomes increasingly challenging, leading to prolonged illness, heightened severity of infections, elevated mortality rates, and increased healthcare costs. Essential oils are lipophilic and volatile mixtures of compounds that have gained attention in research for novel antimicrobial agents. Therefore, the present study evaluated the essential oil of Syzygium cumini leaves (EOSC) in order to prospect its antifungal and trichomonacidal activities. The essential oil from the leaves was extracted by steam distillation and analyzed by GC-MS. Antifungal activity was evaluated using the serial microdilution method. Additionally, the potential of the EOSC as an enhancer of fluconazole (FCZ) action was tested at subinhibitory concentrations. To assess anti-Trichomonas vaginalis activity, concentrations ranging from 15.6 to 500 μg/mL of EOSC were tested. Finally, the SwissADME platform was employed to analyze the physicochemical and pharmacokinetic characteristics of the major component of EOSC. The GC-MS analysis identified 94.24% of the components of EOSC, with α-pinene (51.11%) and nerol (8.25%) as major constituents. EOSC exhibited low antifungal activity against the evaluated Candida strains. However, the combination of EOSC and FCZ reduced the IC50 against Candida krusei from 45.29 to 0.30 μg/mL. EOSC also demonstrated significant activity against T. vaginalis (IC50 = 88.2 μg/mL). In silico prediction with α-pinene showed low toxic action and important physicochemical aspects for drug production. The essential oil of Syzygium cumini emerges as a promising candidate for the discovery of molecules with potential antifungal and anti-Trichomonas vaginalis applications.

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Section: Discussionsupporting

confidence: 90%

Section: Anti-trichomonas Vaginalis Activitymentioning

confidence: 99%

In Vitro and In Silico Biological Evaluation of the Essential Oil from Syzigium cumini Leaves as a Source of Novel Antifungal and Trichomonacidal Agents

Silva,

Moreira,

Bezerra

et al. 2024

Future Pharmacology

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Eugenia Pohliana Leaves Essential Oil Inhibits Fungal Virulence and Restores Antibiotic Efficacy in Multidrug‐Resistant Bacterial Strains

da Costa Silva,

Almeida Menezes,

Pereira da Cruz

et al. 2024

Chemistry & Biodiversity

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This study aims to investigate the essential oil from leaves of E. pohliana (EOEP) in regard to its chemical composition, antimicrobial and drug‐enhancing activity, as well as the reduction of fungal virulence capacity. Chemical characterization using GC‐MS showed as major components the sesquiterpenes δ‐cadinene, Epi‐α‐Muurolol, and bicyclogermacrene. The results of antibacterial tests indicated that Staphylococcus aureus was more sensitive to EOEP, that also enhanced the efficacy of gentamicin, erythromycin, and norfloxacin. EOEP exhibited antifungal properties against Candida albicans, in addition to potentiating the effectiveness of fluconazole against Candida tropicalis. It showed anti‐virulence effects in all fungal strains. These findings underscore Eugenia pohliana as a potential candidate for the prospection of novel therapeutic agents to treat infectious diseases caused by resistant microbes.

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Essential Oils and Terpenic Compounds as Potential Hits for Drugs against Amitochondriate Protists

Menezes

Tasca

2023

TropicalMed

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The human anaerobic or microaerophilic protists Giardia duodenalis, Entamoeba histolytica, and Trichomonas vaginalis are classified as amitochondriate parasites, a group of unicellular organisms that lack canonical mitochondria organelles. These microorganisms suffered adaptations to survive in hostile microenvironments and together represent an increasing threat to public health in developing countries. Nevertheless, the current therapeutic drugs to manage the infections are scarce and often cause several side effects. Furthermore, refractory cases associated with the emergence of parasitic resistance are concerns that guide the search for new pharmacological targets and treatment alternatives. Herein, essential oils and terpenic compounds with activity against amitochondriate parasites with clinical relevance are summarized and insights into possible mechanisms of action are made. This review aims to contribute with future perspectives for research with these natural products as potential alternatives for the acquisition of new molecules for the treatment of amitochondriate protists.

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Anti-Trichomonas vaginalis activity of essential oils extracted from Caatinga Myrtaceae species and chemical composition of Eugenia pohliana DC.

Cited by 3 publications

References 15 publications

In Vitro and In Silico Biological Evaluation of the Essential Oil from Syzigium cumini Leaves as a Source of Novel Antifungal and Trichomonacidal Agents

In Vitro and In Silico Biological Evaluation of the Essential Oil from Syzigium cumini Leaves as a Source of Novel Antifungal and Trichomonacidal Agents

Eugenia Pohliana Leaves Essential Oil Inhibits Fungal Virulence and Restores Antibiotic Efficacy in Multidrug‐Resistant Bacterial Strains

Essential Oils and Terpenic Compounds as Potential Hits for Drugs against Amitochondriate Protists

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