Idiotypes in Medicine: Autoimmunity, Infection and Cancer 1997
DOI: 10.1016/b978-044482807-1/50036-3
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Anti-Idiotypic Antibodies and Idiotypic T Cell Selection in HIV Infection

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(2 citation statements)
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“…22 The 1F7-idiotypic Abs are polyclonal, being selected from several different variable heavy chain genes and being directed against a variety of distinct viral epitopes. 21,23 Furthermore, particular variable heavy chain gene families do not appear to uniformly express the 1F7-idiotype. Indeed, screening of the Ab repertoire from HIVinfected individuals demonstrated the presence of idiotypic and non-idiotypic Abs with common variable heavy chain genes.…”
Section: Repertoire Freeze and Selection Of Bnabs And Other Protectivmentioning
confidence: 99%
See 1 more Smart Citation
“…22 The 1F7-idiotypic Abs are polyclonal, being selected from several different variable heavy chain genes and being directed against a variety of distinct viral epitopes. 21,23 Furthermore, particular variable heavy chain gene families do not appear to uniformly express the 1F7-idiotype. Indeed, screening of the Ab repertoire from HIVinfected individuals demonstrated the presence of idiotypic and non-idiotypic Abs with common variable heavy chain genes.…”
Section: Repertoire Freeze and Selection Of Bnabs And Other Protectivmentioning
confidence: 99%
“…Indeed, screening of the Ab repertoire from HIVinfected individuals demonstrated the presence of idiotypic and non-idiotypic Abs with common variable heavy chain genes. 23 The 1F7-idiotype is represented by a region spread between the CDRH3 and FR3 and is recognized by a monoclonal murine IgM raised by immunization with anti-HIV Abs. 24,25 This anti-idiotypic Ab represents a novel form of anti-idiotypic Ab.…”
Section: Repertoire Freeze and Selection Of Bnabs And Other Protectivmentioning
confidence: 99%