“…22 The 1F7-idiotypic Abs are polyclonal, being selected from several different variable heavy chain genes and being directed against a variety of distinct viral epitopes. 21,23 Furthermore, particular variable heavy chain gene families do not appear to uniformly express the 1F7-idiotype. Indeed, screening of the Ab repertoire from HIVinfected individuals demonstrated the presence of idiotypic and non-idiotypic Abs with common variable heavy chain genes.…”