Anti-IL8/AuNPs-rGO/ITO as an Immunosensing Platform for Noninvasive Electrochemical Detection of Oral Cancer

Verma, Shilpi; Singh, Anu; Shukla, Ajay Kumar; Kaswan, Jyoti; Arora, Kavita; Ramı́rez-Vick, Jaime E.; Singh, Priti; Singh, Surinder P.

doi:10.1021/acsami.7b06839

Cited by 142 publications

(91 citation statements)

References 60 publications

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“…3a. C 1 s core levels have been fitted using five near Gaussian components which correspond to C=C/C-C, C-OH, C-O, C=O, and -COOH [24]. Attachment of PtCo(1:9) to rGO results in further reduction as C-O component of C 1 s core level in PtCo(1:9)/rGO is significantly reduced compared to rGO sample.…”

Section: Resultsmentioning

confidence: 99%

PtCo/rGO nano-anode catalyst: enhanced power density with reduced methanol crossover in direct methanol fuel cell

Baronia

Goel

Kaswan

et al. 2018

Mater Renew Sustain Energy

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The higher methanol utilization efficiency in direct methanol fuel cell (DMFC) is one of the key factors that determine the performance of DMFC. Herein, we have synthesized bimetallic PtCo nano-particles (with optimized Pt:Co ratio) decorated reduced graphene oxide (rGO) nano-composite as anode catalyst. The electrochemical response of optimized PtCo (1:9)/ rGO catalyst revealed efficient oxidation of 5 M methanol in half-cell configuration with ~ 60% Faradaic efficiency. A current density of 463.5 mA/cm 2 and a power density of 136.8 mW/cm 2 were achieved using PtCo (1:9)/rGO anode catalyst in a complete DMFC set-up at 100 °C with 5 M methanol supply which is ~ three times greater as compared to commercial Pt/C (48.03 mW/cm 2 ). The low activation energy of 9.88 kJ/mol indicates the faster methanol oxidation reduction (MOR) kinetics of PtCo (1:9)/rGO anode catalyst. Furthermore, the higher methanol utilization and open-circuit voltage in complete DMFC using PtCo (1:9)/rGO as compared to commercial Pt/C indicate the reduced methanol crossover. The excellent catalytic behavior of PtCo (1:9)/rGO towards MOR and high methanol utilization warrant its potential application as anode catalyst in DMFC.

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Section: Resultsmentioning

confidence: 99%

PtCo/rGO nano-anode catalyst: enhanced power density with reduced methanol crossover in direct methanol fuel cell

Baronia

Goel

Kaswan

et al. 2018

Mater Renew Sustain Energy

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“…The linear fitting curve showed that the peak current had a linear relationship with the square roots of the scanning rates having regression coefficient (R 2 ) of 0.9915 for Ipa and 0.9923 for Ipc respectively, which indicated the redox process to be a diffusion controlled electrochemical process. 32,33 At the same time, the blank CV curve of UOx/Fc/Cu 2 O/GCE in 0.1 M KCl were detected. The results (Fig.…”

Section: Resultsmentioning

confidence: 97%

A highly sensitive uric acid electrochemical biosensor based on a nano-cube cuprous oxide/ferrocene/uricase modified glassy carbon electrode

Yan

Yang

et al. 2020

Sci Rep

101

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A uric acid (UA) electrochemical biosensor was constructed using ferrocene (fc) decorated cuprous oxide (cu 2 o) enhanced electro-active characteristics and covalently immobilized with uricase (Uox) on glassy carbon electrode (Gce). the electrochemical characteristics of the fabricated electrode was analysed by cyclic voltammetry, electrochemical impedance spectroscopy and differential pulse voltammetry (DpV). DpV studies revealed rapid response of fabricated electrode Uox/fc/cu 2 o/Gce towards UA in a wide concentration range of 0.1-1,000 μM with a sensitivity of 1.900 μA mM −1 cm −2 and very low detection limit of 0.0596 μM. A very low magnitude Michaelis-Menten constant (Km) value was evaluated as 34.7351 μM which indicated the chemical attraction of the enzyme towards the UA was much higher. the developed biosensor was successfully applied to detect UA in human urine samples. Moreover, reproducibility and stability studies demonstrated the fabricated UOx/Fc/ cu 2 O/GCE biosensor had high reproducibility with a RSD of 2.8% and good reusability with a RSD of 3.2%. Specificity studies results showed the fabricated biosensor had strong anti-interference ability. the improved sensor performance was attributed to the synergistic electronic properties of cu 2 o and fc that provided enhances delectrocatalytic activity and electron transfer. the present biosensor can be extended for use in clinical settings.

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“…Since, electrocataysis phenomena are surface charge dependent, the concentration of ionic species at electrode surface plays an important role. Therefore, in order to assess the concentration of ionic species ( I * ) using Brown‐Anson model (Equation 5) is used .

true normalI_{p} = \frac{n^{2} F^{2} I^{*} A V}{4 R T}

…”

Section: Resultsmentioning

confidence: 99%

Gold‐Iron Bimetallic Nanoparticles Impregnated Reduced Graphene Oxide Based Nanosensor for Label‐free Detection of Biomarker Related to Non‐alcoholic Fatty Liver Disease

et al. 2019

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We report for the first time a microwave assisted, one pot, direct, and facile synthesis of monodispersed iron‐gold bimetallic nanoparticles (BNPAu‐Fe) using glucose as a reducing agent in merely 90 s. The as such synthesized BNPAu‐Fe were thoroughly characterized using UV‐Vis, XRD, TEM, EDX, elemental mapping, and raman spectroscopy. These BNPAu‐Fe were further impregnated with reduced graphene oxide (rGO) and coated onto glassy carbon electrode (GCE) to develop a sensor probe for label free electrochemical detection of acetaminophen, which is considered to be a most potent biomarker related to non‐alcoholic fatty liver disease. The sensor probe was systematically characterized by cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS). The BNPAu‐Fe‐rGO nanocomposite matrix showed the sensing of acetaminophen with a wide dynamic range between 50 and 800 nM with detection limit (DL) of 0.14 nM (±0.05) nM (RSD<4.12 %) that was lower compared to previously reported acetaminophen sensors. To show the practical application of the sensor probe, acetaminophen was detected in human urine samples, which showed the percentage recovery between 86.65 % and 91.32 %. To the best of our knowledge, this is the first report where BNPAu‐Fe impregnated rGO was used to detect acetaminophen. Interferences due to various molecules such as glucose, serum albumin, glycine, glutamic acid, alanine, citric acid, and ascorbic acid were tested individually and in mixed sample. Long‐term stability of sensor probe was examined which was found to be stable up to 12 weeks. The sensor fabricated using BNPAu‐Fe‐rGO nanocomposite has many attractive features such as; simplicity, rapidity, and label free detection, hence it could be a method of choice for acetaminophen detection in clinical settings.

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Anti-IL8/AuNPs-rGO/ITO as an Immunosensing Platform for Noninvasive Electrochemical Detection of Oral Cancer

Cited by 142 publications

References 60 publications

PtCo/rGO nano-anode catalyst: enhanced power density with reduced methanol crossover in direct methanol fuel cell

PtCo/rGO nano-anode catalyst: enhanced power density with reduced methanol crossover in direct methanol fuel cell

A highly sensitive uric acid electrochemical biosensor based on a nano-cube cuprous oxide/ferrocene/uricase modified glassy carbon electrode

Gold‐Iron Bimetallic Nanoparticles Impregnated Reduced Graphene Oxide Based Nanosensor for Label‐free Detection of Biomarker Related to Non‐alcoholic Fatty Liver Disease

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