Anti-infective potential of<i>Citrus bergamia</i>Risso et Poiteau (bergamot) derivatives: a systematic review

Cirmi, Santa; Bisignano, Carlo; Mandalari, Giuseppina; Navarra, Michele

doi:10.1002/ptr.5646

Cited by 60 publications

(37 citation statements)

References 66 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Thus, different susceptibilities are, probably, imputable to the strains tested, rather than to oils compounds. Our best MIC result (0.625 μL/mL – 0.625 % v/v) is higher than value reported by Cirmi et al (2016) (0.125 % v/v) on a single L. monocytogenes strain.…”

Section: Discussioncontrasting

confidence: 72%

Evaluation of the antibacterial activity of bergamot essential oils on different Listeria monocytogenes strains

et al. 2016

View full text Add to dashboard Cite

Essential oils are aromatic and volatile substances extracted from plants and characterized by antimicrobial activity. The aim of the present study was to evaluate the antibacterial activity (agar disc-diffusion method) of seven different bergamot essential oils (BEOs) on eight Listeria monocytogenes strains. Minimal inhibitory concentration (MIC) of most efficient BEOs was estimated. Extremely variable results for agar disc-diffusion method for L. monocytogenes strains were reported. One of the tested microorganisms resulted insensible to all the BEOs; 3 strains showed an inhibition from weak to null and the remaining 4 a variable susceptibility. Among the BEOs tested, one showed a strong activity against four pathogenic strains. Four BEOs revealed weak, moderate or null activity in all the 7 sensitive strains, while for two oils only a weak or no activity was reported. MIC values were 0.625 μL/mL for the most efficient BEO, 2.5 and 5 μL/mL for the other samples that showed moderate inhibition. Experiment results are significantly related to the strains tested (P<0.01), rather than the BEO employed (P>0.01). In conclusion, we can consider BEO as a natural technological hurdle for Listeria monocytogenes in combination with other preservation strategies. Finally, this study underlines the necessity to evaluate the antimicrobial activity of EOs on a significant strains number of the same bacteria.

show abstract

Section: Discussioncontrasting

confidence: 72%

Evaluation of the antibacterial activity of bergamot essential oils on different Listeria monocytogenes strains

et al. 2016

View full text Add to dashboard Cite

show abstract

“…In this context, we have recently shown that BJe has antioxidant properties [235,236] and is able to suppress pro-inflammatory responses in both in vitro [237,238] and in vivo models [239,240]. Interestingly, evidence showing that BJ did not significantly affect the viability of normal human diploid fibroblast WI-38 cells [229], as well as not provoking any apparent sign of systemic toxicity [231], together with its antimicrobial activity [241,242] and favorable safety/efficacy balance [243], reveals the potential of BJe as an anti-cancer remedy, highlighting that it could represent a novel strategic approach in oncology field. …”

Section: Anti-cancer Properties Of Citrus Juices and Extractsmentioning

confidence: 99%

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

et al. 2016

Self Cite

View full text Add to dashboard Cite

Fruits and vegetables have long been recognized as potentially important in the prevention of cancer risk. Thus, scientific interest in nutrition and cancer has grown over time, as shown by increasing number of experimental studies about the relationship between diet and cancer development. This review attempts to provide an insight into the anti-cancer effects of Citrus fruits, with a focus on their bioactive compounds, elucidating the main cellular and molecular mechanisms through which they may protect against cancer. Scientific literature was selected for this review with the aim of collecting the relevant experimental evidence for the anti-cancer effects of Citrus fruits and their flavonoids. The findings discussed in this review strongly support their potential as anti-cancer agents, and may represent a scientific basis to develop nutraceuticals, food supplements, or complementary and alternative drugs in a context of a multi-target pharmacological strategy in the oncology.

show abstract

“…Amongst CFs, Citrus bergamia Risso et Poiteau (bergamot) has gained an ever‐increasing attention of the scientific community. It found the most appropriate climate conditions in the southern coasts of the Calabria region (Italy), where it is cultivated primarily for the extraction of the essential oil (BEO) from the peel, exploited mainly in cosmetic industry and in aromatherapy (Mannucci et al, ), as well as studied for its activity as antimicrobial (Cirmi, Bisignano, Mandalari, & Navarra, ) and anti‐proliferative agent (Navarra et al, ). Bergamot juice (BJ) has always been considered a by‐product, yet in the last decade, the beneficial effects of its flavonoid‐rich extract (BJe) have been highlighted by several studies (Cirmi et al, ; Ferlazzo, Cirmi, Calapai, et al, ; Mannucci et al, ).…”

Section: Introductionmentioning

confidence: 99%

The link between the AMPK/SIRT1 axis and a flavonoid‐rich extract of Citrus bergamia juice: A cell‐free, in silico, and in vitro study

Maugeri

Ferlazzo

Luca

et al. 2019

Phytotherapy Research

Self Cite

View full text Add to dashboard Cite

A previous report indicated that the flavonoid‐rich extract of bergamot juice (BJe) exerts an anti‐inflammatory effect through the activation of SIRT1 in leukemic monocytes THP‐1 exposed to lipopolysaccharide (LPS). In this study, we deeply investigate the mode of action of BJe, along with its major flavonoids on SIRT1 through cell‐free, in silico, and in vitro experimental models. In the cell‐free assay, all the tested compounds as well as the whole BJe inhibited the deacetylase activity of SIRT1. This finding was reinforced by the results of the in silico study. In THP‐1 cells exposed to LPS, a reduction of SIRT1 activity was observed, effect that was reverted by the pre‐incubation with either BJe or its major flavonoids. This effect was also observed at gene level. Employing an activator and an inhibitor of AMP‐activated protein kinase (AMPK; AICAR and dorsomorphin, respectively), we discovered its involvement in the activation of SIRT1 elicited by BJe or its major flavonoids in whole cell. Our study indicates the dual role of BJe and its components, depending on the employed experimental model as well as reveals their mode of action on the AMPK/SIRT1 axis, suggesting their role as promising candidates in pathologies in which this axis is implied.

show abstract

Anti-infective potential ofCitrus bergamiaRisso et Poiteau (bergamot) derivatives: a systematic review

Cited by 60 publications

References 66 publications

Evaluation of the antibacterial activity of bergamot essential oils on different Listeria monocytogenes strains

Evaluation of the antibacterial activity of bergamot essential oils on different Listeria monocytogenes strains

Chemopreventive Agents and Inhibitors of Cancer Hallmarks: May Citrus Offer New Perspectives?

The link between the AMPK/SIRT1 axis and a flavonoid‐rich extract of Citrus bergamia juice: A cell‐free, in silico, and in vitro study

Contact Info

Product

Resources

About