Anti-infective pyrroloiminoquinone alkaloids from a deep-water Alaskan sponge of the genus Latrunculia

Na, M. K.; Schinazi, Raymond F.; Kelly, Matt; Stone, Robert P.; Hamann, Mark T.

doi:10.1055/s-0028-1084379

Cited by 5 publications

(6 citation statements)

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“…Discorhabdins A (153) and C (154) and dihydrodiscorhabdin C (155) isolated from the Latrunculia genus of the Alaskan sponge species exhibited anti-HCV activity at EC 90 concentrations of <10 μM (Figure 59). 321,322…”

Section: Hcvmentioning

confidence: 99%

Role of Marine Natural Products in the Genesis of Antiviral Agents

2015

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Section: Hcvmentioning

confidence: 99%

Role of Marine Natural Products in the Genesis of Antiviral Agents

2015

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“…The 133 compounds included in this collection, discovered from 2008 to 2010, all displayed an IC 50 below 30 μM against one or more parasites during in vitro screening. It is evident that marine sponges provide the majority of antiparasitic MDSMs with 87 compounds included in 30 publications between 2008 and 2010 [11–14,15•,16,17,18•,19,20•,21–27,28•,29–31,32•,33,34•,35,36•,37•,38•,39•,40]. Marine-derived fungi have produced the next largest set of 20 compounds, reported in only four papers [41–44] and cyanobacteria follow with 11 compounds included in eight reports [45–52].…”

Section: An Important Preamblementioning

confidence: 99%

“…Halogenated metabolites [13,14,16,19,24,28•,33,40]. Secondary metabolites containing halogen atoms are commonly isolated from marine organisms and these compounds often elicit biological responses.…”

Section: A Snapshot Of Selected Natural Productsmentioning

confidence: 99%

The structural diversity and promise of antiparasitic marine invertebrate-derived small molecules

Watts

Tenney

Crews

2010

Current Opinion in Biotechnology

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This review focuses on six important parasitic diseases that adversely affect the health and lives of over one billion people worldwide. In light of the global human impact of these neglected tropical diseases (NTDs), several initiatives and campaigns have been mounted to eradicate these infections once and for all. Currently available therapeutics summarized herein are either ineffective and/or have severe and deleterious side effects. Resistant strains continue to emerge and there is an overall unmet and urgent need for new antiparasitic drugs. Marine-derived small molecules (MDSMs) from invertebrates comprise an extremely diverse and promising source of compounds from a wide variety of structural classes. New discoveries of marine natural product privileged structures and compound classes that are being made via natural product library screening using whole cell in vitro assays are highlighted. It is striking to note that for the first time in history the entire genomes of all six parasites have been sequenced and additional transcriptome and proteomic analyses are available. Furthermore, open and shared, publicly available databases of the genome sequences, compounds, screening assays, and druggable molecular targets are being used by the worldwide research community. A combined assessment of all of the above factors, especially of current discoveries in marine natural products, implies a brighter future with more effective, affordable, and benign antiparasitic therapeutics.

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“…For many years, Latrunculia species have been the focus of studies on natural products, which have revealed high potential of these sponges to synthesize specific bioactive secondary metabolites that have cytotoxic, antitumor, antimicrobial and anti-inflammatory activities (Nèeman et al 1975;Antunes et al 2005;Na et al 2010), such as discorhabdins (Perry et al 1986(Perry et al , 1988aFord and Capon 2000;Samaai and Kelly 2002;Reyes et al 2004;Antunes et al 2005;Samaai et al 2006, Sepe et al 2006Grkovic et al 2008;Grkovic and Copp 2009;Grkovic et al 2010;Makar'eva et al 2010;Na et al 2010;Abbas et al 2011). Porifera (sponges) is very ancient, primitive stem of the metazoans that have unique structural features in their cell membranes and, in particular, for the fatty acid (FA) composition.…”

Section: Introductionmentioning

confidence: 99%

Fatty acid composition and antioxidant activity of Antarctic marine sponges of the genus Latrunculia

et al. 2015

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The fatty acid composition of marine cold-water sponges of genus Latrunculia, namely Latrunculia bocagei Ridley and Dendy, 1886, and Latrunculia biformis Kirkpatrick, 1907, for which no fatty acid data had been previously reported, has been examined. High levels of longchain fatty acids (C 24-30 ) with high unsaturation levels (mainly polyunsaturation), and high incidence of branchedand odd-chain fatty acids in sponges are suggested to be partially connected with their specific cell membrane requirements to surmount the negative effects of low temperatures and to enable growth in extreme environments. Furthermore, variations in the fatty acid profile at the species level may reflect variations in compositions or quantities of symbiotic microorganisms that commonly represent up to 60 % of the sponge wet weight. The fatty acid compositions of lipid-rich sponge extracts from five Latrunculia specimens dredged from the Bransfield Strait near the Antarctic Peninsula, were obtained using supercritical carbon dioxide and analyzed using gas chromatography-mass spectrometry-flame ionization detection. Furthermore, the antioxidant activities of these extracts were determined using the photochemiluminescent method. Along with common fatty acids, the chemical analyses revealed very long-chain fatty acids (C22, C24). Differences were seen for the fatty acid levels between both species and different specimens of the same species. The observed differences do not seem connected to the habitat depth of the specimen, but rather indicate the variations within the associated microbiome. Furthermore, these sponge extracts showed antioxidant activities, confirming that they contain lipidic compounds that strongly scavenge free radicals.

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Anti-infective pyrroloiminoquinone alkaloids from a deep-water Alaskan sponge of the genus Latrunculia

Cited by 5 publications

References 0 publications

Role of Marine Natural Products in the Genesis of Antiviral Agents

Role of Marine Natural Products in the Genesis of Antiviral Agents

The structural diversity and promise of antiparasitic marine invertebrate-derived small molecules

Fatty acid composition and antioxidant activity of Antarctic marine sponges of the genus Latrunculia

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