Anti‐inflammation of bioactive compounds from ethanolic extracts of edible bamboo mushroom (Dictyophora indusiata) as functional health promoting food ingredients

Abstract

The edible bamboo mushroom Dictyophora indusiata, which is rich in food nutrients and has medicinal values, has been investigated for nutrition compositional analysis. Then, three parts (whole mushroom: WE; peel and green mixture: PGE; and core: CE) were determined for antioxidant, MMP-2 inhibition, and anti-inflammatory properties. WE depicted the highest bioactive contents among others. The CE and WE with non-cytotoxic effect on fibroblasts gave high MMP-2 inhibitory activity (44.93% and 30.32%, respectively), compared with L-ascorbic acid (50.65%). For the anti-inflammatory activity, all D. indusiata extracts significantly inhibited the nitric oxide (NO), interleukin (IL)-1β, IL-6, and tumour necrosis factor (TNF)-α secretion compared with the LPS treatment in all-time intervals (P < 0.05). Moreover, WE extract containing various bioactive compounds (polyphenolic, monosaccharide, mucopolysaccharide, allantoin, and alkaloid contents) showed similar anti-inflammatory activity to the standard diclofenac. It can be concluded that WE could be served as functional food ingredients and potential to be healthpromoting products.

High Efficiency In Vitro Wound Healing of Dictyophora indusiata Extracts via Anti-Inflammatory and Collagen Stimulating (MMP-2 Inhibition) Mechanisms

“…This result agreed with a previous study, showing that crude polysaccharide from D. indusiata extracts could reduce inflammatory cytokines (IL-1β, IL-6, and TNF-α) in antibiotic-induced intestinal dysbiosis in mice [41]. Furthermore, ethanolic extracts of D. indusiata could diminish cytokines production in RAW 264.7 cells [42]. Nevertheless, in earlier research, polysaccharide from this mushroom escalated NO, IL-1β, IL-6, and TNF-α production [13], activated IL-1β, and IL-18 secretion in LPS-induced macrophages [14], and IL-1β, IL-6, and IL-18 were enhanced in colitis mice [43].…”

Antioxidation, Anti-Inflammation, and Regulation of SRD5A Gene Expression of Oryza sativa cv. Bue Bang 3 CMU Husk and Bran Extracts as Androgenetic Alopecia Molecular Treatment Substances

“…Nitric oxide assay was used to evaluate the anti-inflammatory activity of extracts by measuring the nitrite, which is the final inert product of nitric oxide in the culture medium [ 41 , 78 ]. RAW 264.7 macrophage cells were seeded at a density of 1 × 10 5 cells/well in 96-well plates and incubated for 24 h. The cells were then pretreated with extracts (0.1 mg/mL), diclofenac sodium (0.1 mg/mL), and solvent as a blank for 2 h. Subsequently, LPS (0 or 1 µg/mL) was administered to the cells to induce an inflammatory response.…”

Synergistics of Carboxymethyl Chitosan and Mangosteen Extract as Enhancing Moisturizing, Antioxidant, Antibacterial, and Deodorizing Properties in Emulsion Cream

“…2,2-azino-bis-(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical scavenging activity was tested according to the method described by Surin et al [ 27 , 29 ] and Ruksiriwanich et al [ 30 ]. ABTS (Sigma-Aldrich, Singapore) reagent solution was freshly prepared by mixing 7 mM of ABTS solution with 2.45 mM of potassium persulfate (Sigma-Aldrich, Singapore).…”