Anti-inflammation Study of Cellulose-Chitosan Biocomposite-Based Tetrapleura tetraptera (Taub) Dried Fruits Aqueous Extract

Abstract

Nanotechnology is making exceptional progress in the medical eld. The development of new systems for the delivery of plant ingredients brings bene ts such as good bioavailability, solubility, sustained release, and enhanced potential. To the best of our knowledge, there is no report on nanocomposites from Tetrapleura tetraptera despite its wide range of ethnopharmacological uses including management of the in ammatory diseases. This study aimed to prepare chitosan and cellulose-based nanocomposite with anti-in ammatory potential. The biocomposite showed an encapsulation e ciency of 69.4%. Their formation was con rmed by a peak at 290 nm in UV-Vis. Infrared spectrophotometry proves the formation of a mixed polysaccharide and polyphenols system. No signs of toxicity and no deaths were found, therefore the lethal dose 50 (LD 50 ) is higher than 2000 mg/kg. The biocomposite has an antiin ammatory activity in vitro with a maximum inhibition of 99.5% and an anti-in ammatory activity in vivo with a maximum inhibition of 98.7% for a dose of 200 mg/kg. The synthesized biocomposite from the aqueous extract of the fruits of Tetrapleura tetraptera showed an anti-in ammatory property with satisfactory safety.