Anti-inflammatory action of interleukin 1 through the pituitary-adrenal axis in rats

Nakamura, Hideo; Motoyoshi, Satoru; Kadokawa, Toshiaki

doi:10.1016/0014-2999(88)90693-0

Cited by 49 publications

(10 citation statements)

References 19 publications

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“…28) Dextran-induced paw edema is activated by histamine and serotonin without leucocytic migration. 29) Kaolin-induced paw edema is mediated by prostaglandin and bradykinin. 30) As shown in Figs.…”

Section: Resultsmentioning

confidence: 99%

.ALPHA.1-Acid Glycoprotein Suppresses Rat Acute Inflammatory Paw Edema through the Inhibition of Neutrophils Activation and Prostaglandin E2 Generation

Matsumoto

Nishi

Kikuchi

et al. 2007

Biological & Pharmaceutical Bulletin

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Section: Resultsmentioning

confidence: 99%

.ALPHA.1-Acid Glycoprotein Suppresses Rat Acute Inflammatory Paw Edema through the Inhibition of Neutrophils Activation and Prostaglandin E2 Generation

Matsumoto

Nishi

Kikuchi

et al. 2007

Biological & Pharmaceutical Bulletin

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“…Alternatively, it may be that chronic AIA is not dependent on IL-1, and other cytokines are responsible for the immunopathogenesis of the arthritis. In rats, intraarticular injection of IL-1 resulted in inhibition of mBSA-induced arthritis (32), suggesting that under certain conditions, IL-1 may have an antiinflammatory effect, possibly via the induction of endogenous corticosterone (33).…”

Section: Discussionmentioning

confidence: 99%

The effect of an interleukin‐1 receptor antagonist protein on type ii collagen–induced arthritis and antigen‐induced arthritis in mice

Wooley

Whalen

Chapman

et al. 1993

Arthritis & Rheumatism

187

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Objective. To investigate the anti-arthritic effect of recombinant human interleukin-1 receptor antagonist protein (IRAP) in two experimental models of arthritis.Methods. Recombinant IRAP was administered daily to mice with type I1 collagen-induced arthritis (CIA) or with antigen-induced arthritis (AIA) provoked by methylated bovine serum albumin (mBSA). Disease incidence and severity were assessed by a clinical index and histologic features. Serum antibody to type I1 collagen, spleen cell proliferation to mBSA, and anti-IRAP antibodies were measured as indices of immune function.Results. IRAP reduced the incidence and delayed the onset of CIA and suppressed the antibody response to type I1 collagen. In contrast, IRAP did not affect the pathogenesis of AIA and had no effect on either humoral or cellular immune responses to mBSA in arthritic mice.Conclusion. These observations suggest that interleukin-1 may play a prominent role in the development of some, but not all, forms of arthritis.Interleukin-1 (IL-1) is present in the synovial fluid of rheumatoid arthritis (RA) patients (1-3). In approximately 40% of joint fluids from patients with RA, osteoarthritis, and miscellaneous connective tis-

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“…IL -la is less potent than IL-lp at stimulating ACTH secretion [ 1,[3][4][5]13]. These studies in dicate that IL -la is approximately 8-fold less potent, a difference which holds when these two cytokines were ad ministered adjacent to the median eminence, a region containing axon terminals immunoreactive for both CRF [32] and IL-1 [3 [33] and, perhaps, IL-1 receptors [14].…”

Section: Discussionmentioning

confidence: 99%

“…Numerous reports have demonstrated that IL-lp is a potent secretagogue for adrenocorticotropin (ACTH) [1][2][3][4][5][6][7], and that it affects the secretion of hypothalamic corticotropin-releasing factor (CRF) [1,[7][8][9] by acting directly at sites within the hypothalamus [10][11][12]. IL -la also appears to induce ACTH secretion, although its efficacy relative to IL-1|) is controversial, with several reports indicating that IL -la is considerably less potent than IL-Ip [1,[3][4][5]13].…”

mentioning

confidence: 99%

Interleukin-1α and Interleukin-1β Stimulate Adrenocorticotropin Secretion in the Rat through a Similar Hypothalamic Receptor(s): Effects of Interleukin-1 Receptor Antagonist Protein

Matta

Linner²,

Sharp³

1993

Neuroendocrinology

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Numerous reports have demonstrated that interleukin-1 β (IL-1β) is a potent secretagogue for adrenocorticotropin (ACTH) and that IL-1α appears to be considerably less efficacious. To clarify apparent differences in the potency of IL- 1α vs. -β on ACTH secretion from a functional perspective, the IL-1 receptor antagonist protein, IRAP, was utilized. Following administration to rats either intravenously (i.v.) or adjacent to the median eminence (intra-ME), IL-1β was approximately 8-fold more potent than IL-1α. IRAP, delivered i.v. or intra-ME, inhibited ACTH secretion due to the administration of IL-1α or -β by the corresponding route. Similar amounts of IRAP were required to attenuate ACTH responses to approximately equieffective i.v. doses of IL-1α (200 ng) or -β (25 ng): IC50 for IRAP inhibition of IL-1α vs. -β was approximately 2.5 or 5.5 µg, respectively. At these IC50 doses, the ratios of IRAP/IL-1 were 12.5 and 220 for IL-1α vs. -β, respectively. These ratios are compatible with mediation by a type I-like IL-1 receptor. To compare these properties of the central IL-1 receptor to a peripheral type I IL-1 receptor in the same species, the IL-1 -enhanced rat thymocyte comitogenesis assay was utilized. Thymocyte proliferation in response to equieffective doses of IL-1α or -β was similarly inhibited by IRAP: approximate IC50 for inhibition of IL-1α vs. -β was 12.5 or 25 ng/ml, respectively. Relative to the dose of IL-1α and -β (5 ng/ml), these amounts of IRAP are within the range required to inhibit (1) the ACTH response to IL-1 in rats, reported herein, and (2) type I IL-1 receptor-mediated responses in peripheral tissues from other species. Thus, the ACTH responses to both IL-1α and IL-1β may be mediated through a central type I-like IL-1 receptor(s), which appears to be similar to the peripheral rat type I receptor. IRAP was effective at inhibiting ACTH secretion stimulated by IL-l when these agents were administered i.v. or into the hypothalamic median eminence, suggesting that type I-like IL-l receptors are present in the median eminence where they are readily accessible to modulation by circulating IL-l.

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Anti-inflammatory action of interleukin 1 through the pituitary-adrenal axis in rats

Cited by 49 publications

References 19 publications

.ALPHA.1-Acid Glycoprotein Suppresses Rat Acute Inflammatory Paw Edema through the Inhibition of Neutrophils Activation and Prostaglandin E2 Generation

.ALPHA.1-Acid Glycoprotein Suppresses Rat Acute Inflammatory Paw Edema through the Inhibition of Neutrophils Activation and Prostaglandin E2 Generation

The effect of an interleukin‐1 receptor antagonist protein on type ii collagen–induced arthritis and antigen‐induced arthritis in mice

Interleukin-1α and Interleukin-1β Stimulate Adrenocorticotropin Secretion in the Rat through a Similar Hypothalamic Receptor(s): Effects of Interleukin-1 Receptor Antagonist Protein

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