Anti-Inflammatory Activities of Euglena gracilis Extracts

Brun, Paola; Piovan, Anna; Caniato, Rosamaria; Costa, Vanessa Dalla; Pauletto, Anthony; Filippini, Raffaella

doi:10.3390/microorganisms9102058

Cited by 5 publications

(2 citation statements)

References 50 publications

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“…The study protocol was reviewed and approved by the local Hospital’s Ethics Committee (registration number CE: 091/2016). The buffy coat was processed as previously described [ 34 ]. Briefly, buffy coat was mixed 1:1 ( vol / vol ) with sterile RPMI 1640 Medium (Life Technologies, Monza, Italy) and layered over Ficoll-Paque PLUS (Merck, Milan, Italy).…”

Section: Methodsmentioning

confidence: 99%

From Ethnobotany to Biotechnology: Wound Healing and Anti-Inflammatory Properties of Sedum telephium L. In Vitro Cultures

Dalla Costa,

Piovan,

Filippini

et al. 2024

Molecules

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Sedum telephium is a succulent plant used in traditional medicine, particularly in Italy, for its efficacy in treating localized inflammation such as burns, warts, and wounds. Fresh leaves or freshly obtained derivatives are directly applied to the injuries for these purposes. However, challenges such as the lack of microbiologically controlled materials and product standardization prompted the exploration of more controlled biotechnological alternatives, utilizing in vitro plant cell cultures of S. telephium. In the present study, we used HPLC-DAD analysis to reveal a characteristic flavonol profile in juices from in vivo leaves and in vitro materials mainly characterized by several kaempferol and quercetin derivatives. The leaf juice exhibited the highest content in total flavonol and kaempferol derivatives, whereas juice from callus grown in medium with hormones and callus suspensions showed elevated levels of quercetin derivatives. The in vitro anti-inflammatory and wound-healing assays evidenced the great potential of callus and suspension cultures in dampening inflammation and fostering wound closure, suggesting quercetin may have a pivotal role in biological activities.

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Section: Methodsmentioning

confidence: 99%

From Ethnobotany to Biotechnology: Wound Healing and Anti-Inflammatory Properties of Sedum telephium L. In Vitro Cultures

Dalla Costa,

Piovan,

Filippini

et al. 2024

Molecules

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“…The photosynthetic protist Euglena gracilis (Euglenoidea), a recently authorised Novel Food species [332], also deserves attention, being a natural producer of anti-inflammatory carotenoids, DHA [333][334][335], and paramylon, an immunomodulatory (1,3)-β-glucan [336] with reported inhibitory activity towards Th17 cells [337].…”

Section: A Road Map For Clinical Uses Of Microalgae In Chronic Inflam...mentioning

confidence: 99%

The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics

Cutolo,

Caferri,

Campitiello

et al. 2023

Marine Drugs

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Rheumatoid arthritis (RA) is an invalidating chronic autoimmune disorder characterized by joint inflammation and progressive bone damage. Dietary intervention is an important component in the treatment of RA to mitigate oxidative stress, a major pathogenic driver of the disease. Alongside traditional sources of antioxidants, microalgae—a diverse group of photosynthetic prokaryotes and eukaryotes—are emerging as anti-inflammatory and immunomodulatory food supplements. Several species accumulate therapeutic metabolites—mainly lipids and pigments—which interfere in the pro-inflammatory pathways involved in RA and other chronic inflammatory conditions. The advancement of the clinical uses of microalgae requires the continuous exploration of phytoplankton biodiversity and chemodiversity, followed by the domestication of wild strains into reliable producers of said metabolites. In addition, the tractability of microalgal genomes offers unprecedented possibilities to establish photosynthetic microbes as light-driven biofactories of heterologous immunotherapeutics. Here, we review the evidence-based anti-inflammatory mechanisms of microalgal metabolites and provide a detailed coverage of the genetic engineering strategies to enhance the yields of endogenous compounds and to develop innovative bioproducts.

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Recent Advances in Cell‐Based In Vitro Models to Recreate Human Intestinal Inflammation

Macedo,

Dias Neto,

Pastrana

et al. 2023

Advanced Science

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Inflammatory bowel disease causes a major burden to patients and healthcare systems, raising the need to develop effective therapies. Technological advances in cell culture, allied with ethical issues, have propelled in vitro models as essential tools to study disease aetiology, its progression, and possible therapies. Several cell‐based in vitro models of intestinal inflammation have been used, varying in their complexity and methodology to induce inflammation. Immortalized cell lines are extensively used due to their long‐term survival, in contrast to primary cultures that are short‐lived but patient‐specific. Recently, organoids and organ‐chips have demonstrated great potential by being physiologically more relevant. This review aims to shed light on the intricate nature of intestinal inflammation and cover recent works that report cell‐based in vitro models of human intestinal inflammation, encompassing diverse approaches and outcomes.

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Anti-Inflammatory Activities of Euglena gracilis Extracts

Cited by 5 publications

References 50 publications

From Ethnobotany to Biotechnology: Wound Healing and Anti-Inflammatory Properties of Sedum telephium L. In Vitro Cultures

From Ethnobotany to Biotechnology: Wound Healing and Anti-Inflammatory Properties of Sedum telephium L. In Vitro Cultures

The Clinical Promise of Microalgae in Rheumatoid Arthritis: From Natural Compounds to Recombinant Therapeutics

Recent Advances in Cell‐Based In Vitro Models to Recreate Human Intestinal Inflammation

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