Anti-Inflammatory Activities of Natural Products Isolated from Soft Corals of Taiwan between 2008 and 2012

Abstract

This review reports details on the natural products isolated from Taiwan soft corals during the period 2008–2012 focusing on their in vitro and/or in vivo anti-inflammatory activities. Chemical structures, names, and literature references are also reported. This review provides useful and specific information on potent anti-inflammatory marine metabolites for future development of immune-modulatory therapeutics.

New Anti-Inflammatory 9,11-Secosterols with a Rare Tricyclo[5,2,1,1]decane Ring from a Formosan Gorgonian Pinnigorgia sp.

“…[1]. In an anti-inflammatory activity test, secosterol 2 displayed significantly inhibitory effects on the release of elastase by human neutrophils and may become lead compounds in future marine anti-inflammatory drug development [10,11]. The gorgonian coral Pinnigorgia sp.…”

Marine Pharmacology in 2012–2013: Marine Compounds with Antibacterial, Antidiabetic, Antifungal, Anti-Inflammatory, Antiprotozoal, Antituberculosis, and Antiviral Activities; Affecting the Immune and Nervous Systems, and Other Miscellaneous Mechanisms of Action

“…secondary metabolites [268]; marine compounds with therapeutic potential in Gram-negative sepsis [269]; antimicrobial properties of tunichromes [270]; drug discovery from marine microbes [271]; (c) antiviral marine pharmacology : marine natural products with anti-HIV activities in the last decade [272]; fucoidans as potential inhibitors of human immunodeficiency virus type 1 (HIV-1) [273]; discovery of potent broad spectrum antivirals derived from marine Actinobacteria [274]; algal lectins for prevention of HIV transmission [275]; (d) antiprotozoal, antimalarial, antituberculosis and antifungal marine pharmacology : trypanocidal activity of marine natural products [276]; natural sesquiterpenes as lead compounds for the design of trypanocidal drugs [277]; antifungal compounds from marine fungi [278]; (e) immuno- and anti-inflammatory marine pharmacology : immunoregulatory properties of bryostatin [279]; bioactive marine peptides as potential anti-inflammatory therapeutics [280]; anti-inflammatory soft coral marine natural products from Taiwan [281]; marine natural products with potential for the therapeutics of inflammatory diseases [282]; antioxidant properties of crude extracts and compounds from brown marine algae [283]; (f) cardiovascular and antidiabetic marine pharmacology : oxidation of marine omega-3 supplements and human health [284]; marine peptides for prevention of metabolic syndrome [285]; antidiabetic effect of marine brown algae-derived phlorotannins [286]; marine bioactive peptides as potential antioxidants [287]; cardioprotective peptides from marine sources [288]; antioxidant and antidiabetic pharmacology of fucoxantin [289]; marine-derived bioactive peptides as new anticoagulants [290]; (g) nervous system marine pharmacology : marine neurotoxins, structures, molecular targets and pharmacology [291]; the phosphatase inhibitor okadaic acid as a tool to identify phosphoepitopes relevant to neurodegeneration [292]; marine toxins and drug discovery targeting nicotinic acetylcholine receptors [293]; marine-derived marine secondary metabolites and neuroprotection [294]; cone snail polyketides active in neurological assays [295]; and (h) miscellaneous molecular targets and uses : small-molecule inhibitors of clinically validated protein and lipid kinases of marine origin [296]; natural products as kinase inhibitors […”

Capgermacrenes A and B, Bioactive Secondary Metabolites from a Bornean Soft Coral, Capnella sp.

“…Soft coral derived secondary metabolites are reported to exhibit promising biological activities such as anti-tumor, antiviral, antifouling and anti-inflammation [2]. Our previous chemical investigation on the soft coral genus Nephthea led to isolation and structural elucidation of a new cembrane diterpene [3], a new sterol [4] and a new norsesquiterpenoid [5], along with several known compounds [5].…”