Anti-inflammatory activities of the methanol extracts and an isolated furanoditerpene constituent of Sphenocentrum jollyanum Pierre (Menispermaceae)

Moody, J. O.; Robert, Valerie; Connolly, Joseph D.; Houghton, Peter J.

doi:10.1016/j.jep.2005.08.051

Cited by 94 publications

(79 citation statements)

References 18 publications

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“…The mechanisms of anti-inflammatory activity may be related to the antiphlogistic action of the tannins. Non-steroidal anti-inflammatory drugs (NSAID) such as indomethacin used in this study are known to inhibit cyclooxygenase enzymes I and II which are implicated in the production of inflammation-mediating agent prostaglandin E 2 (PGE 2 ) from arachidonic acid (Dhara et al 2000, Wu 2003, Moody et al 2006. The pattern of anti-inflammatory and analgesic activities exhibited by this extract was similar to that of indomethacin which suggests that the plant's activity may be mediated by cyclooxygenase I and II inhibition.…”

Section: Discussionmentioning

confidence: 63%

“…The percentage inhibition of the inflammation was calculated from the formula: % inhibition=D 0 -D t /D 0 x100 where D 0 was the average inflammation (hind paw oedema) of the control group of rats at a given time; and D t was the average inflammation of the drug treated (i.e. extracts or reference indomethacin) rats at the same time (Gupta et al 2005, Sawadogo et al 2006, Moody et al 2006). …”

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

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Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

Adedapo¹,

Sofidiya²,

Afolayan³

2008

RBT

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Abstract:Margaritaria discoidea is a medicinal plant used for the treatment of various body pains in Central, Eastern and Southern Africa. The aqueous extract of its stem bark was investigated for its anti-inflammatory and analgesic activities in animal models. The extract at 50, 100 and 200mg/kg body weight reduced significantly the formation of oedema induced by carrageenan and histamine. In the acetic acid-induced writhing model, the extract had a good analgesic effect characterized by a reduction in the number of writhes when compared to the control. Similarly, the extract caused dose-dependent decrease of licking time and licking frequency in rats injected with 2.5% formalin. These results were also comparable to those of indomethacin, the reference drug used in this study. Acute toxicity test showed that the plant may be safe for pharmacological uses. This study has provided some justification for the folkloric use of the plant in several communities for conditions such as stomachache, pain and inflammations. Rev. Biol. Trop. 57 (4): 1193-1200. Epub 2009 December 01.

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Section: Discussionmentioning

confidence: 63%

Section: Anti-inflammatory Activitiesmentioning

confidence: 99%

Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

Adedapo¹,

Sofidiya²,

Afolayan³

2008

RBT

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show abstract

“…In other studies, phytochemical investigation of L. obtusa indicates the presence of other secondary metabolites like terpenoids and alkaloids (Demirel et al 2011;Johnson et al 2012). Terpenoids were reported to possess significant analgesic and anti-inflammatory activities (Neukirch et al 2005;Moody et al 2006). A new diterpene compound extracted from the red algae Laurencia glandulifera was reported to possess in vitro and in vivo anti-inflammatory activity (Chatter et al 2011) by the inhibition of NF-jB activation, TNF-a production, NO release and COX-2 expression.…”

Section: Discussionmentioning

confidence: 99%

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

Lajili

Deghrigue

Amor

et al. 2016

Pharmaceutical Biology

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Context: Red algae have been recognized as a rich natural source of compounds possessing interesting biological and pharmacological activities. Objective: This work investigates anti-inflammatory, analgesic and gastroprotective activities of MeOH/ CH 2 Cl 2 crude extract and its fractions F1 (50% MeOH) and F2 (80% MeOH) from the whole alga plant Laurencia obtusa Hudson (Rhodomelaceae). Materials and methods: Anti-inflammatory activity was evaluated in vitro using cytometric bead array (CBA) technology to follow up the secretion of tumour necrosis factor alpha (TNF-a) in lipopolysaccharide activated THP-1 monocytic cells at doses of 10-250 lg/mL and in vivo using carrageenan-induced paw oedema in Wistar rats at doses of 25, 50, 100 and 200 mg/kg. Crude extract and fractions were tested at the doses of 25, 50, 100 and 200 mg/kg for peripheral and central analgesic activity by acetic acid-induced writhing test and hot-plate method, respectively, in Swiss albino mice. Gastroprotective activity was evaluated using HCl/ethanol-induced gastric ulcer test in rats at doses of 25, 50, 100 and 200 mg/kg. Results: Crude extract, F1 and F2 showed an interesting inhibition of TNF-a secretion with IC 50 values of 25, 52 and 24 lg/mL, respectively, and a significant anti-inflammatory activity in vivo (p < 0.01), 3 h after carrageenan injection, the oedema inhibition was 55.37%, 52.18% and 62.86%, respectively, at the dose of 100 mg/kg. Furthermore, they showed a significant peripheral analgesic activity with 53.79%, 55.92% and 57.37% (p < 0.01) of writhing inhibition, respectively. However, no significant activity was found in the hotplate test. An interesting gastroprotective effect was observed with crude extract and its fractions F1 and F2 with a gastric ulcer inhibition of 65.48%, 77.42% and 81.29%, respectively, at the dose of 50 mg/kg. Discussion and conclusion: These results suggest that L. obtusa might be used as a potential source of natural anti-inflammatory and analgesic agents with gastroprotective effect. ARTICLE HISTORY

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“…It is a small erect sparsely branched shrub, growing up to 1.5 m in height. The roots which are bright yellow with a sour taste (Neuwinger, 1996) are used as 'chewsticks', relief for constipation, as a stomachic, as a cough medicine, for sickle cell disease, rheumatism and other inflammatory conditions (Burkill, 1985;Iwu, 1993;Moody et al, 2006). The root of S. jollyanum is chewed as a central nervous system (CNS) stimulant and aphrodisiac in Ghana (Abbiw, 1990;Irvine, 1961).…”

Section: Introductionmentioning

confidence: 99%

“…Some scientific work has been done on this plant in relation to its antiviral and anti-inflammatory activities (Moody et al, 2002a;Moody et al, 2002b;Moody et al, 2006), anti-oxidant and anti-angiogenic property (Nia et al, 2004) and recently, Raji et al, (2006), have shown that methanolic extract of root of S. jollyanum increased the testosterone levels in albino rats as well as a dose-dependent reduction in progressive motility of spermatozoa, viability and total sperm count.…”

Section: Introductionmentioning

confidence: 99%

The effects of sphenocentrum jollyanum Pierre root extract on sexual behaviourand hormonal levels in rodents

Owiredu¹,

Nafiu²,

Amissah³

et al. 2007

Jnl Sci Tech

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Roots of S. jollyanum are considered as sexual stimulant in Ghanaian traditional medicine. The present study is aimed at investigating the effect of an ethanolic extract of the root of S. jollyanum on sexual behaviour of male mice and reproductive hormones in male rats. Extract of S. jollyanum (100, 300 and 1000 mg/kg p.o) stimulated mounting and mating behaviour by increasing mounting frequency, intromission frequency and prolonged ejaculation latency. In addition, a decrease in mounting latency, intromission latency and postejaculatory interval was observed. These observations were indicative of increased libido and enhanced sexual behaviour. However, the dose-response curves of some of the parameters measured (attempted mounts, mounting frequency, anogenital sniffing and penile licking) were U-shaped i.e. the effects observed were absent at higher doses. Also the effect of the extract on FSH, LH, prolactin and testosterone levels in rats were determined at weekly intervals for three weeks. Levels of testosterone were increased 4-fold by the third week and there was about 30% increase in FSH levels by the second week which dropped by the third week. Surprisingly, LH levels were reduced by the second week with no significant change in levels of prolactin. These results suggest that there may be more than one mechanism of action of the extract. The immediate increase in sexual behaviour by extract of S. jollyanum may be due to a central stimulatory effect whilst long-term effect might be due to increased testosterone levels. The stimulation of sexual behaviour in male mice and rats supports the claims for its traditional usage in sexual disorders.

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Anti-inflammatory activities of the methanol extracts and an isolated furanoditerpene constituent of Sphenocentrum jollyanum Pierre (Menispermaceae)

Cited by 94 publications

References 18 publications

Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

Anti-inflammatory and analgesic activities of the aqueous extracts of Margaritaria discoidea (Euphorbiaceae) stem bark in experimental animal models

In vitroimmunomodulatory activity andin vivoanti-inflammatory and analgesic potential with gastroprotective effect of the Mediterranean red algaLaurencia obtusa

The effects of sphenocentrum jollyanum Pierre root extract on sexual behaviourand hormonal levels in rodents

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